Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Galina V. Flint"'
Autor:
Joseph D. Powers, Kristina B. Kooiker, Allison B. Mason, Abigail E. Teitgen, Galina V. Flint, Jil C. Tardiff, Steven D. Schwartz, Andrew D. McCulloch, Michael Regnier, Jennifer Davis, Farid Moussavi-Harami
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Dilated cardiomyopathy (DCM) is often associated with sarcomere protein mutations that confer reduced myofilament tension–generating capacity. We demonstrated that cardiac twitch tension-time integrals can be targeted and tuned to prevent DCM remod
Externí odkaz:
https://doaj.org/article/55eaf6caa6cf482c970857331e9b9758
Autor:
Ross C. Bretherton, Isabella M. Reichardt, Kristin A. Zabrecky, Alex J. Goldstein, Logan R.J. Bailey, Darrian Bugg, Timothy S. McMillen, Kristina B. Kooiker, Galina V. Flint, Amy Martinson, Jagdambika Gunaje, Franziska Koser, Elizabeth Plaster, Wolfgang A. Linke, Michael Regnier, Farid Moussavi-Harami, Nathan J. Sniadecki, Cole A. DeForest, Jennifer Davis
Publikováno v:
bioRxiv
Inherited mutations in contractile and structural genes, which decrease cardiomyocyte tension generation, are principal drivers of dilated cardiomyopathy (DCM)– the leading cause of heart failure1,2. Progress towards developing precision therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d6d727242a076bceeee75ea3108274
https://europepmc.org/articles/PMC9900749/
https://europepmc.org/articles/PMC9900749/
Autor:
Kristina B. Kooiker, Saffie Mohran, Weikang Ma, Galina V. Flint, Kerry Y. Kao, Lin Qi, Timothy McMillen, Stephanie Neys, Christian Mandrycky, Thomas C. Irving, Michael A. Geeves, Michael Regnier, Farid Moussavi-Harami
Publikováno v:
Biophysical Journal. 122:453a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb64d520c9df40b3573d39d63b251aff
https://doi.org/10.1016/j.bpj.2022.11.2439
https://doi.org/10.1016/j.bpj.2022.11.2439
Autor:
Reese A, Jagadambika J. Gunaje, April Stempien-Otero, Darrian Bugg, Jennifer Davis, Galina V. Flint, Cole A. DeForest, Beach K, Ross C. Bretherton
SUMMARYDynamic fibroblast state transitions are responsible for the heart’s fibrotic response to injury, raising the possibility that tactical control of these transitions could alter maladaptive fibrotic outcomes. Transcriptome maturation by the R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eb19b7171ec810b8a500eb6c3f1f9c9
https://doi.org/10.1101/2021.01.26.428279
https://doi.org/10.1101/2021.01.26.428279
Autor:
Andrew D. McCulloch, Jennifer Davis, Galina V. Flint, Steven D. Schwartz, Kristina B. Kooiker, Jil C. Tardiff, Allison B. Mason, Michael Regnier, Abigail E. Teitgen, Joseph D. Powers, Farid Moussavi-Harami
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 20 (2020)
JCI Insight, Vol 5, Iss 20 (2020)
Dilated cardiomyopathy (DCM) is often associated with sarcomere protein mutations that confer reduced myofilament tension–generating capacity. We demonstrated that cardiac twitch tension-time integrals can be targeted and tuned to prevent DCM remod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298133dfb75267fe7fa5f937fd171df1
https://pubmed.ncbi.nlm.nih.gov/32931484
https://pubmed.ncbi.nlm.nih.gov/32931484
Autor:
Stephen C. Kolwicz, Kiyoto Nishi, Yun-Wei A. Hsu, Galina V. Flint, Arianne Caudal, Nathan D. Roe, Pei Wang, Outi Villet, Michael Regnier, Wang Wang, Dan Shao, Rong Tian
Publikováno v:
Circulation
Background: Increased fatty acid oxidation (FAO) has long been considered a culprit in the development of obesity/diabetes mellitus–induced cardiomyopathy. However, enhancing cardiac FAO by removing the inhibitory mechanism of long-chain fatty acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60501eb381936d17f99f3ee0d0e961f1
https://pubmed.ncbi.nlm.nih.gov/32597196
https://pubmed.ncbi.nlm.nih.gov/32597196
Autor:
Galina V. Flint, Matthew C. Childers, Chen-Ching Yuan, Kimberly J. McCabe, Jason D. Murray, Thomas C. Irving, Carla Zuzek, Valerie Daggett, Farid Moussavi-Harami, Saffie Mohran, Joseph D. Powers, Andrew D. McCulloch, Romi Castillo, Weikang Ma, Michael Regnier
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 23
The naturally occurring nucleotide 2-deoxy-adenosine 5'-triphosphate (dATP) can be used by cardiac muscle as an alternative energy substrate for myosin chemomechanical activity. We and others have previously shown that dATP increases contractile forc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5873416b8e20f3578ab7bfaf42bd3944
https://escholarship.org/uc/item/7d16d992
https://escholarship.org/uc/item/7d16d992
Autor:
Michael Regnier, Jil C. Tardiff, Jennifer Davis, Joseph D. Powers, Farid Moussavi-Harami, Galina V. Flint
Publikováno v:
Biophysical Journal. 116:264a-265a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::378c32c2295e6ac838a4e2eadec38e26
https://doi.org/10.1016/j.bpj.2018.11.1436
https://doi.org/10.1016/j.bpj.2018.11.1436
Autor:
Galina V. Flint, Corrado Poggesi, Michael Regnier, Beatrice Scellini, Nicoletta Piroddi, Chiara Tesi
Publikováno v:
Journal of Muscle Research and Cell Motility. 36:11-23
Tropomyosin (Tm) plays a central role in the regulation of muscle contraction and is present in three main isoforms in skeletal and cardiac muscles. In the present work we studied the functional role of a- and bTm on force development by modifying th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe3a2c8f4144c11042ea44604a27899
https://doi.org/10.1007/s10974-014-9394-9
https://doi.org/10.1007/s10974-014-9394-9
Autor:
Vijay S. Rao, Galina V. Flint, Scott Lundy, Alice Ward Racca, Michael Regnier, Donald E. Born, Anita E. Beck, Michael J. Bamshad
Publikováno v:
The Journal of Physiology. 591:3049-3061
Little is known about the contraction and relaxation properties of fetal skeletal muscle, and measurements thus far have been made with non-human mammalian muscle. Data on human fetal skeletal muscle contraction are lacking, and there are no publishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73f300d768faa64e47568520ec3bbee8
https://doi.org/10.1113/jphysiol.2013.252650
https://doi.org/10.1113/jphysiol.2013.252650