Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Galina Kiriakova"'
Autor:
Vladislav V. Glinsky, Galina Kiriakova, Olga V. Glinskii, Valeri V. Mossine, Thomas P. Mawhinney, James R. Turk, Anna B. Glinskii, Virginia H. Huxley, Janet E. Price, Gennadi V. Glinsky
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 9, Pp 901-909 (2009)
At present, there is no efficient curative therapy for cancer patients with advanced metastatic disease. Targeting of antiapoptotic molecules acting on the mitochondrial apoptosis pathway could potentially augment antimetastatic effect of cytotoxic d
Externí odkaz:
https://doaj.org/article/d6ddc17cc8954ba39640bad71d960c7c
Autor:
Garth Powis, Eric Jonasch, Federico A. Monzon, Jose Karam, Thai H. Ho, Mena Abdelmelek, Galina Kiriakova, Bryant G. Darnay, Robert Lemos, Vuvi Nguyen, Mei Yee Koh
Clear-cell renal cell cancer (CRCC) is initiated typically by loss of the tumor-suppressor VHL, driving constitutive activation of hypoxia-inducible factor-1 (HIF1) and HIF2. However, whereas HIF1 has a tumor-suppressor role, HIF2 plays a distinct ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da13a9a4aec4ec75dddb7e18fbfd89f9
https://doi.org/10.1158/0008-5472.c.6506001
https://doi.org/10.1158/0008-5472.c.6506001
Autor:
Garth Powis, Eric Jonasch, Federico A. Monzon, Jose Karam, Thai H. Ho, Mena Abdelmelek, Galina Kiriakova, Bryant G. Darnay, Robert Lemos, Vuvi Nguyen, Mei Yee Koh
Supplemental methods. A, B) Sequences for the A) P117 Luc, and B) P117 HRE reporters containing the HAF binding site, the hypoxia responsive element (HRE) and the HIF ancillary sequence (HAS), with the restriction enzyme sites used for ligation into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92cd78c5b212858b1a206297b3195499
https://doi.org/10.1158/0008-5472.22402158.v1
https://doi.org/10.1158/0008-5472.22402158.v1
Autor:
Robert Lemos, Garth Powis, Lewis R. Roberts, Carl F. Ware, Xiuping Liu, John R. Sedy, Vasileos Bekiaris, Timothy Sargis, Adriana Charbono, Mei Yee Koh, Geoffrey Grandjean, Mihai Gagea, Galina Kiriakova
Publikováno v:
Hepatology. 63:1576-1591
The hypoxia-inducible factor (HIF), HIF-1, is a central regulator of the response to low oxygen or inflammatory stress and plays an essential role in survival and function of immune cells. However, the mechanisms regulating nonhypoxic induction of HI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe3fa4c2709cc01ee963f5eef6033a4
https://doi.org/10.1002/hep.28468
https://doi.org/10.1002/hep.28468
Autor:
Geoffrey Bartholomeusz, Chengcheng Hu, Timothy B. Palculict, Galina Kiriakova, Brian P. James, Galen Hostetter, Sunil R. Hingorani, Daniel D. Von Hoff, Richard G. Posner, Meraj Aziz, Garth Powis, Julie G. Izzo, Taly R. Spivak-Kroizman, Michael J. Demeure, Mena Abdelmelek
Publikováno v:
Cancer Research. 73:3235-3247
Pancreatic cancer is characterized by a desmoplastic reaction that creates a dense fibroinflammatory microenvironment, promoting hypoxia and limiting cancer drug delivery due to decreased blood perfusion. Here, we describe a novel tumor–stroma inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84ef194735de62b134cde90a6e8f49f
https://doi.org/10.1158/0008-5472.can-11-1433
https://doi.org/10.1158/0008-5472.can-11-1433
Autor:
Mary M. McCarthy, Galina Kiriakova, Dina Lev, Janet E. Price, Harriet M. Kluger, David L. Rimm, Yuval Kluger, Robert L. Camp
Publikováno v:
Cancer Research. 65:5578-5587
Metastasis is the primary cause of death from breast cancer. A xenograft model was used to identify genes potentially involved with metastasis, comparing expression in the poorly metastatic GI101A human breast cancer cell line and a highly metastatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8470408fef2ad6596d7a59cdd97a7d11
https://doi.org/10.1158/0008-5472.can-05-0108
https://doi.org/10.1158/0008-5472.can-05-0108
Publikováno v:
Clinical and Experimental Metastasis. 20:515-523
In vivo models utilizing orthotopic injection of tumor cells into nude mice have proven valuable for the study of metastasis. However, breast cancers are among the more difficult of human tumors to grow in immunodeficient mice, with a relatively low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10b35dd0100ebbc306d3ae801cda9d29
https://doi.org/10.1023/a:1025837631179
https://doi.org/10.1023/a:1025837631179
Autor:
Mei Yee Koh, Vuvi H. Nguyen, Jose A. Karam, Federico A. Monzon, Robert Lemos, Garth Powis, Thai H. Ho, Eric Jonasch, Bryant G. Darnay, Mena Abdelmelek, Galina Kiriakova
Clear-cell renal cell cancer (CRCC) is initiated typically by loss of the tumor-suppressor VHL, driving constitutive activation of hypoxia-inducible factor-1 (HIF1) and HIF2. However, whereas HIF1 has a tumor-suppressor role, HIF2 plays a distinct ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bb2951a33ae7d24bf57d777dce2293
https://europepmc.org/articles/PMC4297521/
https://europepmc.org/articles/PMC4297521/
Autor:
Ronald H. Kremer, Galina Kiriakova, Xiao Mei Rao, Janet E. Price, L. B. Lachman, Bulent Ozpolat
Publikováno v:
Cancer Gene Therapy. 8:259-268
The gene for HER2/neu is overexpressed in 30–40% of breast and ovarian cancers, and this overexpression correlates with increased metastasis and poor prognosis. The HER2/neu gene product, a transmembrane protein kinase member of the EGF receptor fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acc32eb0ddbaf955f8b6605580ff0c3
https://doi.org/10.1038/sj.cgt.7700300
https://doi.org/10.1038/sj.cgt.7700300
Autor:
Le Zhan, Imad Shureiqi, Grace L. Guo, Scott Kopetz, Galina Kiriakova, Veerabhadran Baladandayuthapani, Ann Marie Bailey, Nan He, Caimiao Wei, Han Liang, Curtis R. Pickering, Garth Powis, Julie G. Izzo, Dipen M. Maru
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 306(1)
Farnesoid X receptor (FXR) is a bile acid nuclear receptor described through mouse knockout studies as a tumor suppressor for the development of colon adenocarcinomas. This study investigates the regulation of FXR in the development of human colon ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb4e1553735fb812b4a8638f1d7bbf9
https://pubmed.ncbi.nlm.nih.gov/24177031
https://pubmed.ncbi.nlm.nih.gov/24177031