Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Galina I. Botchkina"'
Autor:
Rebecca A Rowehl, Stephanie Burke, Agnieszka B Bialkowska, Donald W Pettet, Leahana Rowehl, Ellen Li, Eric Antoniou, Yuanhao Zhang, Roberto Bergamaschi, Kenneth R Shroyer, Iwao Ojima, Galina I Botchkina
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99091 (2014)
BACKGROUND: Colorectal cancer (CRC) has the third highest mortality rates among the US population. According to the most recent concept of carcinogenesis, human tumors are organized hierarchically, and the top of it is occupied by malignant stem cell
Externí odkaz:
https://doaj.org/article/79cf04a38b86401081f6390a0c94a870
Autor:
Galina I Botchkina, Edison S Zuniga, Rebecca H Rowehl, Rosa Park, Rahuldev Bhalla, Agnieszka B Bialkowska, Francis Johnson, Lorne M Golub, Yu Zhang, Iwao Ojima, Kenneth R Shroyer
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e69884 (2013)
Prostate cancer is the second leading cause of cancer death among men. Multiple evidence suggests that a population of tumor-initiating, or cancer stem cells (CSCs) is responsible for cancer development and exceptional drug resistance, representing a
Externí odkaz:
https://doaj.org/article/1299df8b4bc343d5b17edc94e1bedd08
Autor:
Orit Ravid-Hermesh, Mordechai Deutsch, Yana Shafran, Elena Afrimzon, Naomi Zurgil, Galina I. Botchkina, Maria Sobolev, Iwao Ojima, Sergei Moshkov
Publikováno v:
Lab on a Chip. 16:1047-1062
Specific phenotypic subpopulations of cancer stem cells (CSCs) are responsible for tumor development, production of heterogeneous differentiated tumor mass, metastasis, and resistance to therapies. The development of therapeutic approaches based on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570d5d331234d0c3f93e542e7215cde0
https://doi.org/10.1039/c6lc00014b
https://doi.org/10.1039/c6lc00014b
Publikováno v:
Bioorganic Chemistry. 95:103523
It has been shown that inclusion of CF3O and CHF2O groups to drug candidates often improve their pharmacological properties, especially metabolic stability, membrane permeability and PK profile. Moreover, the unique non-spherical structure of the OCH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2987567c3a5f0ad532140275bb69fcf
https://doi.org/10.1016/j.bioorg.2019.103523
https://doi.org/10.1016/j.bioorg.2019.103523
Autor:
Florence Gattacecca, Rana El Sadda, James Egan, Galina I. Botchkina, Gulzar Ahmad, Iwao Ojima, Mansoor M. Amiji
PURPOSE: The main purpose of this study was to formulate an oil-in-water nanoemulsion of a next generation taxoid DHA-SBT-1214 and evaluate its biodistribution and pharmacokinetics. METHODS: DHA-SBT-1214 was encapsulated in a fish oil containing nano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0e3a9cc520e9f876a692670b7a3657
https://europepmc.org/articles/PMC6151135/
https://europepmc.org/articles/PMC6151135/
The main aim of this study was to evaluate the therapeutic efficacy of an oil-in-water nanoemulsion formulation encapsulating DHA-SBT-1214, a novel omega-3 fatty acid conjugated taxoid prodrug, against prostate cancer stem cells. Nanoemulsions of DHA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce7a1473f3ab77c42bf80eaa4255b2f
https://europepmc.org/articles/PMC5591776/
https://europepmc.org/articles/PMC5591776/
Autor:
Marko Kornmann, Galina I. Botchkina, Elaine Gavin, Yu Wan, Kenji Kudo, Yuan Wang, Jingfang Ju, Bo Song, Skjalg Bruheim, Øystein Fodstad, Yaguang Xi, Andrea Formentini
Publikováno v:
Oncogene
In this study, our high throughput microRNA (miRNA) expression analysis revealed that the expression of miR-140 was associated with chemosensitivity in osteosarcoma tumor xenografts. Tumor cells ectopically transfected with miR-140 were more resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ff9977a5709bb41ff9d5a19caa8eda
https://doi.org/10.1038/onc.2009.274
https://doi.org/10.1038/onc.2009.274
Autor:
Inna L. Botchkina, Kevin T. Watkins, David E. Rivadeneira, Martin S. Karpeh, Galina I. Botchkina
Publikováno v:
Molecular Medicine. 14:45-54
Early detection and accurate staging of gastrointestinal (GI) cancers are difficult. The aim of this study was to evaluate whether telomerase activity (TA) in exfoliated/disseminated epithelial cells could be used as a reliable marker for GI cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d66d8af9a38be6cd774f30bd04c11f
https://doi.org/10.2119/2007-00069.botchkina
https://doi.org/10.2119/2007-00069.botchkina
Autor:
Galina I. Botchkina, Inna L. Botchkina, Vera Gorfinkel, Olga Kosobokova, Evgeni A. Kabotyanski, Boris Gorbovitski
Publikováno v:
Biosensors and Bioelectronics. 21:1924-1931
Post-PCR fragment analysis was conducted using our single photon detection-based DNA sequencing instrument in order to substantially enhance the detection of nucleic biomarkers. Telomerase Repeat Amplification Protocol assay was used as a model for r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e01c64e5fc2929cdb34650c12a0f077
https://doi.org/10.1016/j.bios.2006.01.015
https://doi.org/10.1016/j.bios.2006.01.015
Autor:
Galina I. Botchkina, Zelik Frischer, Howard L. Adler, Inna L. Botchkina, Alex Kirshenbaum, Roger H. Kim
Publikováno v:
Clinical Cancer Research. 11:3243-3249
Purpose: Prostate cancer is the most common male malignancy and the second leading cause of male cancer death; therefore, there is urgent necessity for noninvasive assays for early detection of prostate cancer. Obtaining prostate tumor samples surgic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d5ca20dc362258b203e7a2a98231b2
https://doi.org/10.1158/1078-0432.ccr-04-1919
https://doi.org/10.1158/1078-0432.ccr-04-1919