Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Galina I Lepesheva"'
Autor:
Tatiana Y. Hargrove, David C. Lamb, Jarrod A. Smith, Zdzislaw Wawrzak, Steven L. Kelly, Galina I. Lepesheva
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The molecular evolution of cytochromes P450 and associated redox-driven oxidative catalysis remains a mystery in biology. It is widely believed that sterol 14α-demethylase (CYP51), an essential enzyme of sterol biosynthesis, is the ancestor
Externí odkaz:
https://doaj.org/article/4ea05976d35d4cc8a02923713ed89ab7
Autor:
Tatiana Y. Hargrove, Laura Friggeri, Zdzislaw Wawrzak, Suneethi Sivakumaran, Eugenia M. Yazlovitskaya, Scott W. Hiebert, F. Peter Guengerich, Michael R. Waterman, Galina I. Lepesheva
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 8, Pp 1552-1563 (2016)
Rapidly multiplying cancer cells synthesize greater amounts of cholesterol to build their membranes. Cholesterol-lowering drugs (statins) are currently in clinical trials for anticancer chemotherapy. However, given at higher doses, statins cause seri
Externí odkaz:
https://doaj.org/article/968e408f60a54a6ab3edc1f98e3a4e63
Autor:
Galina I. Lepesheva, W. David Nes, Tatiana Y. Hargrove, Girish Rachakonda, F. Peter Guengerich, Fernando Villalta, Zdzislaw Wawrzak
Publikováno v:
Journal of Medicinal Chemistry. 64:17511-17522
Naegleria fowleri is the protozoan pathogen that causes primary amoebic meningoencephalitis (PAM), with the death rate exceeding 97%. The amoeba makes sterols and can be targeted by sterol biosynthesis inhibitors. Here, we characterized N. fowleri st
Autor:
Tatiana Y, Hargrove, Zdzislaw, Wawrzak, Girish, Rachakonda, W David, Nes, Fernando, Villalta, F Peter, Guengerich, Galina I, Lepesheva
Publikováno v:
J Med Chem
Naegleria fowleri is the protozoan pathogen that causes primary amoebic meningoencephalitis (PAM), with the death rate exceeding 97%. The amoeba makes sterols and can be targeted by sterol biosynthesis inhibitors. Here, we characterized N. fowleri st
Autor:
Kevin D. McCarty, Molly E. Sullivan, Yasuhiro Tateishi, Tatiana Y. Hargrove, Galina I. Lepesheva, F. Peter Guengerich
Publikováno v:
Journal of Biological Chemistry. :104841
Autor:
Roy Mwenechanya, Julie Kovářová, Nicholas J Dickens, Manikhandan Mudaliar, Pawel Herzyk, Isabel M Vincent, Stefan K Weidt, Karl E Burgess, Richard J S Burchmore, Andrew W Pountain, Terry K Smith, Darren J Creek, Dong-Hyun Kim, Galina I Lepesheva, Michael P Barrett
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005649 (2017)
Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understandi
Externí odkaz:
https://doaj.org/article/6745f44e729541bfb242217950694ec9
Publikováno v:
J Biol Chem
CYP51 enzymes (sterol 14α-demethylases) are cytochromes P450 that catalyze multistep reactions. The CYP51 reaction occurs in all biological kingdoms and is essential in sterol biosynthesis. It removes the 14α-methyl group from cyclized sterol precu
Autor:
Tatiana Y. Hargrove, Zdzislaw Wawrzak, Jialin Liu, Michael R. Waterman, W. David Nes, Galina I. Lepesheva
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 2, Pp 311-320 (2012)
Sterol 14α-demethylase (CYP51) that catalyzes the removal of the 14α-methyl group from the sterol nucleus is an essential enzyme in sterol biosynthesis, a primary target for clinical and agricultural antifungal azoles and an emerging target for ant
Externí odkaz:
https://doaj.org/article/c40939c9d3c346a897504b45a1c2974f
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 11, Pp 2000-2007 (2004)
14α-Demethylase (CYP51) is a key enzyme in all sterol biosynthetic pathways (animals, fungi, plants, protists, and some bacteria), catalyzing the removal of the C-14 methyl group following cyclization of squalene. Based on mutations found in CYP51 g
Externí odkaz:
https://doaj.org/article/31e564f395704f1882fc74b9ac014730
Autor:
Galina I. Lepesheva, Marcos Meuser Batista, Constança Britto, Beatriz Philot Pavão, Denise da Gama Jaen Batista, Fernando Villalta, Leticia Rocha Quintino Souza, Cristiane França da Silva, Girish Rachakonda, Otacilio C. Moreira, F. H. Guedes-da-Silva, Maria de Nazaré Correia Soeiro
Publikováno v:
ACS Infectious Diseases. 5:365-371
Up to now, no vaccines are available for Chagas disease, and the current therapy is largely unsatisfactory. Novel imidazole-based scaffolds of protozoan sterol 14α-demethylase (CYP51) inhibitors have demonstrated potent antiparasitic activity with n