Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Galina Apostolova"'
Autor:
Ryan A. V. Bell, Mohammad H. Al-Khalaf, Steve Brunette, Dalal Alsowaida, Alphonse Chu, Hina Bandukwala, Georg Dechant, Galina Apostolova, F. Jeffrey Dilworth, Lynn A. Megeney
Publikováno v:
Cells, Vol 11, Iss 6, p 966 (2022)
The induction of lineage-specific gene programs are strongly influenced by alterations in local chromatin architecture. However, key players that impact this genome reorganization remain largely unknown. Here, we report that the removal of the specia
Externí odkaz:
https://doaj.org/article/401e503390fc466fa68ff97a37303090
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007890 (2019)
During CNS development, the nuclear protein SATB2 is expressed in superficial cortical layers and determines projection neuron identity. In the adult CNS, SATB2 is expressed in pyramidal neurons of all cortical layers and is a regulator of synaptic p
Externí odkaz:
https://doaj.org/article/1bed413d48f84f28af46809cf793161b
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
SATB2 is a DNA binding protein that specifically binds the nuclear matrix attachment region and functions as a regulator of the transcription of large chromatin domains. Unlike its well addressed role during brain development, the role of SATB2 in ad
Externí odkaz:
https://doaj.org/article/fc006fb3ff1b4046850e5e5ae9391d78
Autor:
Laura Whitton, Galina Apostolova, Dietmar Rieder, Georg Dechant, Stephen Rea, Gary Donohoe, Derek W Morris
Publikováno v:
PLoS Genetics, Vol 14, Iss 7, p e1007515 (2018)
SATB2 is associated with schizophrenia and is an important transcription factor regulating neocortical organization and circuitry. Rare mutations in SATB2 cause a syndrome that includes developmental delay, and mouse studies identify an important rol
Externí odkaz:
https://doaj.org/article/8b9b4c5258674499968e3da707c36fb1
Autor:
Clemens Jaitner, Chethan Reddy, Andreas Abentung, Nigel Whittle, Dietmar Rieder, Andrea Delekate, Martin Korte, Gaurav Jain, Andre Fischer, Farahnaz Sananbenesi, Isabella Cera, Nicolas Singewald, Georg Dechant, Galina Apostolova
Publikováno v:
eLife, Vol 5 (2016)
SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively expressed in pyramidal neurons of two brain regions important for memory for
Externí odkaz:
https://doaj.org/article/3ef5e8fc74a14c26a3f979b4746b720c
Autor:
Elisabetta Indelicato, Alexander Kirchmair, Matthias Amprosi, Stephan Steixner, Wolfgang Nachbauer, Andreas Eigentler, Nico Wahl, Galina Apostolova, Anne Krogsdam, Rainer Schneider, Julia Wanschitz, Zlatko Trajanoski, Sylvia Boesch
Publikováno v:
Human Molecular Genetics.
Objective: In Friedreich’s ataxia (FRDA), the most affected tissues are not accessible to sampling and available transcriptomic findings originate from blood-derived cells and animal models. Herein, we aimed at dissecting for the first time the pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a5766003dd147012f48ff3be747fdad
https://doi.org/10.1093/hmg/ddad051
https://doi.org/10.1093/hmg/ddad051
Autor:
Nico Wahl, Sergio Espeso-Gil, Paola Chietera, Aodán Laighneach, Derek W. Morris, Prashanth Rajarajan, Schahram Akbarian, Georg Dechant, Galina Apostolova
SummarySATB2is genetically associated with human intelligence. Since SATB2 protein structure predicts a function in DNA looping, we analyzed the impact of SATB2 on 3D genome architecture and chromatin accessibility in cortical neurons. Our data revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8af4ee7a177331ace6dff9039375cf22
https://doi.org/10.1101/2022.12.27.522010
https://doi.org/10.1101/2022.12.27.522010
Autor:
Galina Apostolova, Isabella Cera, Patrick Feurle, Andre Fischer, Georg Dechant, Derek W. Morris, Andreas Abentung, Aodán Laighneach, Nico Wahl, Simon Sprenger, Michael Bucher, Eduard Stefan, Laura Whitton, David Teis, Cornelia Ablinger
Publikováno v:
The EMBO journal 40(3), e103701 (2021). doi:10.15252/embj.2019103701
The EMBO Journal
The EMBO Journal
SATB2 is a schizophrenia risk gene and is genetically associated with human intelligence. How it affects cognition at molecular level is currently unknown. Here, we show that interactions between SATB2, a chromosomal scaffolding protein, and the inne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6c12f384e7aa85602f7c65d2d82289
https://pub.dzne.de/record/155832
https://pub.dzne.de/record/155832
Autor:
Mark A. Ungless, Izabela Harabula, Sarah A. Teichmann, Georg Dechant, Leonid Serebreni, Mandy Meijer, Vedran Franke, Luna Zea Redondo, Warren Winick-Ng, Andreas Abentung, Aleksandra A. Kolodziejczyk, Gonçalo Castelo-Branco, Rieke Kempfer, Christoph J. Thieme, Francesco Musella, Mario Nicodemi, Alexander Kukalev, Simona Bianco, Ana Pombo, Elena Torlai Triglia, Galina Apostolova, Luca Fiorillo, Eleanor J. Paul, Dominik Szabo, Ehsan Irani, Ibai Irastorza Azcarate, Andrea M. Chiariello, Altuna Akalin
Publikováno v:
BioRxiv
bioRxiv
bioRxiv
Neurons and oligodendrocytes are terminally differentiated cells that perform highly specialized functions, which depend on cascades of gene activation and repression to retain homeostatic control over a lifespan. Gene expression is regulated by thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe90361604c71833d8063e04409eeb74
Autor:
Georg Dechant, Steve Brunette, Alphonse Chu, Jeffrey Dilworth, Galina Apostolova, Mohammad Al-Khalaf, Ryan A. V. Bell, Lynn A. Megeney
SummaryInduction of lineage-specific gene programs are strongly influenced by alterations in local chromatin architecture. However, key players that impact this genome reorganization remain largely unknown. Here, we report that removal of special AT-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e92c4567c7ca3a20bf1ee9f3173a13
https://doi.org/10.1101/2019.12.19.883579
https://doi.org/10.1101/2019.12.19.883579