Výsledky vyhledávání - "Galigniana, Mario Daniel"

The Hsp90-binding immunophilin FKBP52 fosters neurodifferentiation and neuroregeneration in murine models

Autor: Daneri Becerra, Cristina del Rosario, Galigniana, Mario Daniel

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The term immunophilin involves a family of proteins whose signature domain shows peptidyl-prolyl-(cis/trans)-isomerase (PPIase) enzymatic activity, i.e., the reversible cis/trans interconversion of Xaa-Pro bonds (Erlejman et al., 2013; Annett et al.,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::e7a09a048ce224a281501cb599d0fa43
https://www.nrronline.org/article.asp?issn=1673-5374

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Regulation of FKBP51 and FKBP52 functions by post-translational modifications

Autor: Daneri Becerra, Cristina del Rosario, Zgajnar, Nadia Romina, Lotufo, Cecilia Maricel, Ramos Hryb, Ana Belen, Piwien Pilipuk, Graciela, Galigniana, Mario Daniel

FKBP51 and FKBP52 are two iconic members of the family of peptidyl-prolyl-(cis/trans)-isomerases (EC: 5.2.1.8), which comprises proteins that catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds in unfolded and partially folded polyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3498::cffe7a8729fa3dc45fed9a526bcba09f
https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20190334/221203/Regulation-of-FKBP51-and-FKBP52-functions-by

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Nuclear receptors: a historical perspective

Autor: Mazaira, Gisela Ileana, Zgajnar, Nadia Romina, Lotufo, Cecilia Maricel, Daneri Becerra, Cristina del Rosario, Sivils, Jeffrey C., Soto, Olga B., Cox, Marc B., Galigniana, Mario Daniel

These receptors exhibit a multitude of roles in cell biology and hence have attracted a great deal of interest in the drug discovery field. It is not certain whether these receptors evolved independently or an ancestral protein acquired various funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3498::2243e7d4de2d4fe220f704a7a2836c13
https://link.springer.com/protocol/10.1007/978-1-4939-9195-2_1

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Reconstitution of the steroid receptor heterocomplex

Autor: Mazaira, Gisela Ileana, Galigniana, Mario Daniel

Steroid receptors are members of a subfamily of the nuclear receptor superfamily. They play a dual role of steroid hormone receptors and transcription factors. Actually, these receptors are steroid-activated transcription factors. Classical soluble r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3498::0c233d2282475b5c96f31f305ecb341a
https://pubmed.ncbi.nlm.nih.gov/31041743/

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Immunophilins FKBP51 and FKBP52

Autor: Zgajnar, Nadia Romina, de Leo, Sonia Alejandra, Lotufo, Cecilia Maricel, Erlejman, Alejandra Giselle, Piwien Pilipuk, Graciela, Galigniana, Mario Daniel

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-isomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) through which they bind to the 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::895e01841deb3d6def44bd9c20642272
https://www.mdpi.com/2218-273X/9/2/52

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Regulatory role of heat-shock proteins in autoimmune and inflammatory diseases

Autor: Daneri Becerra, Cristina del Rosario, Galigniana, Mario Daniel

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Classically, molecular chaperones play a pivotal role in the maintenance of cellular proteostasis and thus, in the safeguarding of the cell homeostasis while reducing the deleterious effects of extracellular and intracellular stresses. They are also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6d22a364b1e51f6bed9c29753f14d625
https://www.oatext.com/Regulatory-role-of-heat-shock-proteins-in-autoimmune-and-inflammatory-diseases.php#Article

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Biological relevance of Hsp90-binding immunophilins in cancer development and treatment

Autor: Mazaira, Gisela Ileana, Camisay, Maria Fernanda, de Leo, Sonia Alejandra, Erlejman, Alejandra Giselle, Galigniana, Mario Daniel

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Immunophilins are a family of intracellular receptors for immunosuppressive drugs. Those immunophilins that are related to immunosuppression are the smallest proteins of the family, i.e., FKBP12 and CyPA, whereas the other members of the family have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8180f79a397c6f0d1f53eaad5c1c19b6
Wiley Online Library

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Molecular chaperones shape steroid receptor action and pharmacologic strategies

Autor: Mazaira, Gisela Ileana, Lagadari, Mariana, Elerjman, Alejandra G., Galigniana, Mario Daniel

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Chaperone oligomers exist in cell cytosols as preassembled heterocomplexes that function as protein-folding molecular machines able to assemble essential proteins related to families that embrace steroid receptors, protein-kinases, ubiquitin-ligases,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::668b4d8ab53e8dc5f8ea1cb57d012636
http://www.jacobspublishers.com/index.php/j-j-cell-mol-bio-1-1-004

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NF-κB Transcriptional Activity Is Modulated by FK506-binding Proteins FKBP51 and FKBP52: A ROLE FOR PEPTIDYL-PROLYL ISOMERASE ACTIVITY*

Autor: Erlejman, Alejandra Giselle, de Leo, Sonia Alejandra, Mazaira, Gisela Ileana, Molinari, Alejandro Martín, Camisay, Maria Fernanda, Fontana, Vanina Andrea, Cox, Mark, Piwien Pilipuk, Graciela, Galigniana, Mario Daniel

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Hsp90 binding immunophilins FKBP51 and FKBP52 modulate steroid receptor trafficking and hormone-dependent biological responses. With the purpose to expand this model to other nuclear factors that are also subject to nuclear-cytoplasmic shuttling, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::03ee8912e2b194847d799d80b546a60d
https://europepmc.org/articles/PMC4176250/

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The biology of molecular chaperones: very complex activities for quite simple proteins

Autor: Galigniana, Mario Daniel

From a social perspective, the term chaperone refers to a person, usually a matron, who used to accompany young ladies in public and supervise young people at a social gathering to ensure proper behavior. By analogy, proteins that assist others in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3498::cf0b92d2d536d2e85709c55e5944bb07
http://www.eurekaselect.com/121709/article

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