Výsledky vyhledávání - "Galigniana, M.D."

The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress

Autor: Gallo, L.I., Lagadari, M., Piwien-Pilipuk, G., Galigniana, M.D.

Publikováno v: J. Biol. Chem. 2011;286(34):30152-30160
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

Confocal microscopy images revealed that the tetratricopeptide repeat motif (TPR) domain immunophilin FKBP51 shows colocalization with the specific mitochondrial marker Mito-Tracker. Signal specificity was tested with different antibodies and by FKBP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::c5aeb314fb92b0677b22a8237801dcd8

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Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin β

Autor: Echeverría, P.C., Mazaira, G., Erlejman, A., Gomez-Sanchez, C., Pilipuk, G.P., Galigniana, M.D.

Publikováno v: Mol. Cell. Biol. 2009;29(17):4788-4797
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

Glucocorticoid receptor (GR) is cytoplasmic in the absence of ligand and localizes to the nucleus after steroid binding. Previous evidence demonstrated that the hsp90-based heterocomplex bound to GR is required for the efficient retrotransport of the

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Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes

Autor: Presman, D.M., Hoijman, E., Ceballos, N.R., Galigniana, M.D., Pecci, A.

Publikováno v: Endocrinology 2006;147(11):5452-5459
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

The antiapoptotic effect of melatonin (MEL) has been described in several systems. In particular, MEL inhibits glucocorticoid-mediated apoptosis. Our group previously demonstrated that in the thymus, MEL inhibits the release of Cytochrome C from mito

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Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus

Autor: Galigniana, M.D., Harrell, J.M., O'Hagen, H.M., Ljungman, M., Pratt, W.B.

Publikováno v: J. Biol. Chem. 2004;279(21):22483-22489
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein. However, the connection between p53 and the dynein motor protein complex has not been established. Here, we show that hsp90·b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::7f9392ceb334cc779c399a80e63ba967

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Evidence for glucocorticoid receptor transport on microtubules by dynein

Autor: Harrell, J.M., Murphy, P.J.M., Morishima, Y., Chen, H., Mansfield, J.F., Galigniana, M.D., Pratt, W.B.

Publikováno v: J. Biol. Chem. 2004;279(52):54647-54654
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

Rapid, ligand-dependent movement of glucocorticoid receptors (GR) from cytoplasm to the nucleus is hsp90-dependent, and much of the movement system has been defined. GR-hsp90 heterocomplexes isolated from cells contain one of several hsp90-binding im

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Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex

Autor: Galigniana, M.D., Morishima, Y., Gallay, P.A., Pratt, W.B.

Publikováno v: J. Biol. Chem. 2004;279(53):55754-55759
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

Although cyclophilin A (CyP-A) is a relatively abundant small immunophilin present in the cytoplasm of all mammalian cells, its general function(s) in the absence of the immunosuppressant drug cyclosporin A is not known. In contrast, the high molecul

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Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging: Correlation with post-translational modification of MR and decreased ADP-ribosylatable level of elongation factor 2 in kidney cells

Autor: Piwien-Pilipuk, G., Ayala, A., Machado, A., Galigniana, M.D.

Publikováno v: J. Biol. Chem. 2002;277(14):11896-11903
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

Acute and chronic treatments of mice with the glutathione-depleting agent, L-buthionine-(SR)-sulfoximine (BSO), impaired the mineralocorticoid receptor (MR)-dependent biological response by inhibiting aldosterone binding. This steroid-binding inhibit

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