Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Galietta L. J."'
Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel
Autor:
Renda M., Barreca M., Borrelli A., Spano' V., Montalbano A., Raimondi M. V., Bivacqua R., Musante I., Scudieri P., Guidone D., Buccirossi M., Genovese M., Venturini A., Bandiera T., Barraja P., Galietta L. J. V.
Publikováno v:
Scientific Reports. 13
F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation. The F508del defect can be targeted with pharmacological corre
Autor:
Vega G., Guequen A., Johansson M. E. V., Arike L., Martinez-Abad B., Nystrom E. E. L., Scudieri P., Pedemonte N., Millar-Buchner P., Philp A. R., Galietta L. J., Hansson G. C., Flores C. A.
[This corrects the article DOI: 10.3389/fphys.2019.00694.].
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::554ac4d0bdc368a047d8f12700a2d62f
http://hdl.handle.net/11588/782412
http://hdl.handle.net/11588/782412
Autor:
Simonin J., Bille E., Crambert G., Noel S., Dreano E., Edwards A., Hatton A., Pranke I., Villeret B., Cottart C. -H., Vrel J. -P., Urbach V., Baatallah N., Hinzpeter A., Golec A., Touqui L., Nassif X., Galietta L. J. V., Planelles G., Sallenave J. -M., Edelman A., Sermet-Gaudelus I.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::a23450137477cdb6b9397b8787da1d4f
http://hdl.handle.net/11588/782283
http://hdl.handle.net/11588/782283
Autor:
Tomati V., Caci E., Ferrera L., Pesce E., Sondo E., Cholon D. M., Quinney N. L., Boyles S. E., Armirotti A., Ravazzolo R., Galietta L. J. V., Gentzsch M., Pedemonte N.
The unit for the concentration of peptide in the proliferation study was incorrectly reported in the Results and Methods sections and the Figure 4 legend. The corrected sentences, with sections indicated, are below. Results Evaluation of Tα-1 sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::2a028541401ffec90510e9b30e7e468e
http://hdl.handle.net/11588/795518
http://hdl.handle.net/11588/795518
Akademický článek
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Autor:
CATENI, FRANCESCA, ZACCHIGNA, MARINA, Pedemonte N., Galietta L. J. V., Mazzei M. T., Fossa P., Giampieri M., Mazzei M.
The gating of the CFTR chloride channel is altered by a group of mutations that cause cystic fibrosis. This gating defect may be corrected by small molecules called potentiators. Some 1,4-dihydropyridine (DHP) derivatives, bearing a thiophen-2-yl and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6b5d3b292d27e725d061405ea5468f03
http://hdl.handle.net/11368/2297176
http://hdl.handle.net/11368/2297176
The green fluorescent protein YFP-H148Q is sensitive to halides by a mechanism involving halide binding and a shift in pK(a). However, a limitation of YFP-H148Q is its low halide sensitivity, with K(d)>100 mM for Cl(-). Indicators with improved sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::13462605a170b5f9132f05094de7464c
http://hdl.handle.net/11588/739455
http://hdl.handle.net/11588/739455
Publikováno v:
Experimental physiology. 97(2)
The Ca(2+)-activated Cl(-) channels (CaCCs) are involved in a variety of physiological functions, such as transepithelial anion transport, smooth muscle contraction and olfaction. Recently, the question of the molecular identity of CaCCs has apparent
Transforming growth factor beta (TGFbeta) determines a nearly complete inhibition of cystogenesis by MDCK cells grown in collagen I-enriched matrices in vitro. In order to elucidate the mechanism implicated in this phenomenon, we performed a series o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::52b811722a67446ca0d2080cfb005155
http://hdl.handle.net/11588/739611
http://hdl.handle.net/11588/739611
Autor:
Zegarra-Moran, O, Galietta, L J
The question of whether a single molecule can account for every observed swelling-activated Cl- current deserves to be addressed and biophysical description seems to be an adequate criterion to classify these channels. We studied the biophysical prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::de85cf21e210d6356f4bcb3ae182e408
http://hdl.handle.net/11588/739612
http://hdl.handle.net/11588/739612