IL-13Rα2/TGF-β bispecific CAR-T cells counter TGF-β-mediated immune suppression and potentiate anti-tumor responses in glioblastoma.

Autor: Hou AJ; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA., Shih RM; Department of Molecular Biology, University of California, Los Angeles, California, USA., Uy BR; Department of Neurosurgery, University of California, Los Angeles, California, USA., Shafer A; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA., Chang ZL; Department of Molecular Biology, University of California, Los Angeles, California, USA., Comin-Anduix B; Department of Surgery, University of California, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA., Guemes M; Department of Medicine, Division of Hematology/Oncology, University of California, Los Angeles, California, USA., Galic Z; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Department of Medicine, Division of Hematology/Oncology, University of California, Los Angeles, California, USA., Phyu S; Department of Neurosurgery, University of California, San Francisco, California, USA., Okada H; Department of Neurosurgery, University of California, San Francisco, California, USA.; Parker Institute for Cancer Immunotherapy Center at UCSF, San Francisco, California, USA., Grausam KB; Board of Governor's Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Breunig JJ; Board of Governor's Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Brown CE; Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, USA., Nathanson DA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA., Prins RM; Department of Neurosurgery, University of California, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California, USA., Chen YY; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, USA.; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.; Parker Institute for Cancer Immunotherapy Center at UCLA, Los Angeles, California, USA.

Publikováno v: Neuro-oncology [Neuro Oncol] 2024 Oct 03; Vol. 26 (10), pp. 1850-1866.

Pigs as Clinically Relevant Models for Synergizing Interventional Oncology and Immunotherapy.

Autor: Lee J; Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, California., Boas FE; Department of Radiology, City of Hope, Duarte, California., Duran-Struuck R; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania., Gaba RC; Department of Radiology, University of Illinois Health, Chicago, Illinois., Schachtschneider KM; Department of Radiology, University of Illinois Health, Chicago, Illinois., Comin-Anduix B; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California., Galic Z; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Haile S; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Bassir A; Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, California., Chiang J; Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, California. Electronic address: CJChiang@mednet.ucla.edu.

Publikováno v: Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2024 Jun; Vol. 35 (6), pp. 809-817.e1. Date of Electronic Publication: 2024 Jan 12.

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Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis.

Autor: Chen BY; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.; Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, California, USA., Salas JR; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.; Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, California, USA., Trias AO; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.; Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, California, USA., Perez Rodriguez A; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.; Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, California, USA., Tsang JE; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA., Guemes M; Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA., Le TM; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, California, USA., Galic Z; Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA., Shepard HM; Enosi Life Sciences, Eugene, Oregon, USA., Steinman L; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Nathanson DA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, California, USA., Czernin J; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, California, USA., Witte ON; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, California, USA.; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA., Radu CG; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.; Ahmanson Translational Imaging Division, University of California, Los Angeles, Los Angeles, California, USA., Schultz KA; Trethera Corporation, Los Angeles, California, USA., Clark PM; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA.; Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, California, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, California, USA.

Publikováno v: Immunology [Immunology] 2023 Jan; Vol. 168 (1), pp. 152-169. Date of Electronic Publication: 2022 Sep 04.