Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Galia Oberkovitz"'
Autor:
Talia Golan, Talia Shentzer Kutiel, Maya Gottfried, Alona Zer, Aviad Zick, Ayelet Shai, Larissa Ryvo, Julia Dudnik, Nir Peled, Galia Oberkovitz, Fan Yang, Shmuel Sharoni, Changting Meng, Dayana Michel, Eric Sbar, Jatin J. Shah, Michael Kauffman, Sharon Shacham, Ravit Geva
Publikováno v:
Journal of Clinical Oncology. 40:110-110
110 Background: Single agent selinexor, an oral selective inhibitor of nuclear export (SINE), showed activity against heavily pretreated CRC with RAS mutations (mut) or wildtype (wt) in 2 clinical studies. In preclinical studies, selinexor showed sup
Autor:
Osnat Bohana-Kashtan, Margaret M. Showel, Martin S. Tallman, Jessica K. Altman, Abi Vainstein-Haras, James M. Foran, Avichai Shimoni, Arnon Aharon, Michal Abraham, Yaron Pereg, Shaul Kadosh, Arnon Nagler, Ella Sorani, Yishai Ofran, Galia Oberkovitz, Naveen Pemmaraju, Amnon Peled, Ahmed AlRawi, Emil Samara, Geoffrey L. Uy, Tzipi Lustig, Michael Andreeff, Irit Glicko-Kabir, Stephen Shaw, Jorge E. Cortes, Carlos E. Bueso-Ramos, Adam Foley-Comer, Gautam Borthakur, John F. DiPersio, Jacob M. Rowe
Publikováno v:
CancerReferences. 127(8)
Background CXCR4 mediates the retention and survival of acute myelogenous leukemia blasts in bone marrow and contributes to their resistance to chemotherapy. The authors evaluated a combination of the high-affinity CXCR4 antagonist BL-8040 with high-
Autor:
Lidiya Vorobiyov, Tsvee Lapidot, Steffen Jung, Yehudit Zaltsman, Atan Gross, Hagit Niv, Galia Oberkovitz, Ori Brenner, Maria Maryanovich
Publikováno v:
Nature Cell Biology. 14:535-541
BID, a BH3-only BCL2 family member, functions in apoptosis as well as the DNA-damage response. Our previous data demonstrated that BID is an ATM effector acting to induce cell-cycle arrest and inhibition of apoptosis following DNA damage. Here we sho
Autor:
Seema Gupta, Pankaj Gaur, Abi Vainstein Haras, Vivek Verma, Amnon Peled, Samir N. Khleif, Galia Oberkovitz, Ella Sorani
Publikováno v:
Journal of Clinical Oncology. 36:73-73
73 Background: C-X-C chemokine receptor type 4 (CXCR4) helps to retain the hematopoietic stem cells (HSC) in the bone marrow (BM). CXCR4 binds to its ligand CXCL12/SDF1 which is constitutively expressed in the BM thereby inhibiting the mobilization o
Autor:
Amnon Peled, Joon Oh Park, Carlos Becerra, Galia Oberkovitz, Valeriya Semenisty, Steven Shaw, Robert A. Ramirez, Tzipora M. Lustig, Salomon M. Stemmer, Katrina Pedersen, Daniel D. Von Hoff, Ron Epelbaum, Manuel Hidalgo, Mitesh J. Borad, Ella Sorani, Erkut Borazanci, Talia Golan, Brian M. Wolpin, Ravit Geva, Abi Vainstein Haras
Publikováno v:
Journal of Clinical Oncology. 36:88-88
276 Background: BL-8040 is a novel CXCR4 antagonist being developed for multiple oncology indications. Preclinical studies demonstrated that BL-8040 increases the number of immune cells in peripheral blood and promotes CD8+ T cell infiltration into o
Autor:
Reuven Or, Orly Eizenberg, Klein Shiri, Eyal Benami, Rotem Golan, Galia Oberkovitz, Eithan Galun, Arnon Nagler, Katia Beider, Baruch Bulvik, Abi Vainstein, Yoseph Caraco, Hanna Wald, Amnon Peled, Michal Abraham
Publikováno v:
Blood. 130:660-660
Introduction: Lifelong blood cell production is dependent on rare hematopoietic stem cells (HSCs) to perpetually replenish mature cells via a series of lineage-restricted intermediates. The bulk of HSCs are CD34+, however, most CD34+ cells are lineag
Publikováno v:
Experimental Cell Research. 315:2616-2623
Apoptosis is frequently regulated by different protein kinases including protein kinase C family enzymes. Both inhibitory and stimulatory effects were demonstrated for several of the different PKC isoforms. Here we show that the novel PKC isoform, PK
Publikováno v:
Scopus-Elsevier
The Hodgkin-Reed-Sternberg (HRS) malignant cells in Hodgkin's lymphoma (HL) originate from germinal center B lymphocytes that did not undergo apoptosis. Protein Kinase C (PKC), a family of serine/threonine kinases, plays a crucial role in signal tran
Publikováno v:
Cell Death & Differentiation. 14:1628-1634
The BH3-only BID protein acts as a sentinel to interconnect specific death signals to the core apoptotic pathway. Our previous data demonstrated that BID is important for both S-phase arrest and cell death following DNA damage, and that the cell cycl
Autor:
Rachel Sarig, Iris Kamer, Yehudit Zaltsman, Richard C. Marcellus, Limor Regev, Yaniv Lerenthal, Gal Haimovich, Hagit Niv, Atan Gross, Galia Oberkovitz
Publikováno v:
Cell. 122:593-603
SummaryThe “BH3-only” proapoptotic BCL-2 family members are sentinels of intracellular damage. Here, we demonstrated that the BH3-only BID protein partially localizes to the nucleus in healthy cells, is important for apoptosis induced by DNA dama