Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Galia Blum"'
Autor:
Atif Ahmed Siddiqui, Emmanuelle Merquiol, Reut Bruck-Haimson, Joud Hirbawi, Hana Boocholez, Irit Cohen, Yonghong Yan, Meng Qiu Dong, Galia Blum, Ehud Cohen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated
Externí odkaz:
https://doaj.org/article/e3c24ee5acc343fd87a60513d5ca45ab
Autor:
Preety Panwar, Jacob Bastholm Olesen, Galia Blum, Jean-Marie Delaisse, Kent Søe, Dieter Brömme
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Cathepsin K (CatK), an essential collagenase in osteoclasts (OCs), is a potential therapeutic target for the treatment of osteoporosis. Using live-cell imaging, we monitored the bone resorptive behaviour of OCs during dose-dependent inhibiti
Externí odkaz:
https://doaj.org/article/92cb3c72ac144f1391fde56b99a57085
Publikováno v:
ACS Omega, Vol 9, Iss 6, Pp 6965-6975 (2024)
Externí odkaz:
https://doaj.org/article/bc41978bd5df41cfb2a13184282eba65
Autor:
Odelia Tepper-Shimshon, Nino Tetro, Roa’a Hamed, Natalia Erenburg, Emmanuelle Merquiol, Gourab Dey, Agam Haim, Tali Dee, Noa Duvdevani, Talin Kevorkian, Galia Blum, Eylon Yavin, Sara Eyal
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1211 (2024)
The space environment can affect the function of all physiological systems, including the properties of cell membranes. Our goal in this study was to explore the effect of simulated microgravity (SMG) on the cellular uptake of small molecules based o
Externí odkaz:
https://doaj.org/article/a437c92619c2452886187536e3081d90
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/c1896e33ea22491bb595ad959ade00d5
Autor:
Tommy Weiss-Sadan, David Maimoun, Diana Oelschlagel, Farnusch Kaschani, Danny Misiak, Hanmant Gaikwad, Yael Ben-Nun, Emannuelle Merquiol, Adi Anaki, Darya Tsvirkun, Markus Kaiser, Patrick Michl, Israel Gotsman, Galia Blum
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 3, Pp 550-572 (2019)
Externí odkaz:
https://doaj.org/article/cc7862781b9e48159bc7e84ff1a784b8
Autor:
Yonit Yitzhak, Hanmant Gaikwad, Tommy Weiss-Sadan, Emmanuelle Merquiol, Boris Turk, Galia Blum
Publikováno v:
Molecules, Vol 27, Iss 3, p 842 (2022)
Cysteine cathepsin proteases are found under normal conditions in the lysosomal compartments of cells, where they play pivotal roles in a variety of cellular processes such as protein and lipid metabolism, autophagy, antigen presentation, and cell gr
Externí odkaz:
https://doaj.org/article/438747093c6747078330898ca0c90b67
Autor:
Hadas Gibori, Shay Eliyahu, Adva Krivitsky, Dikla Ben-Shushan, Yana Epshtein, Galia Tiram, Rachel Blau, Paula Ofek, Joo Sang Lee, Eytan Ruppin, Limor Landsman, Iris Barshack, Talia Golan, Emmanuelle Merquiol, Galia Blum, Ronit Satchi-Fainaro
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targe
Externí odkaz:
https://doaj.org/article/9f5041d02f9946eea0f19af66fa313d8
Autor:
Dror Alishekevitz, Svetlana Gingis-Velitski, Orit Kaidar-Person, Lilach Gutter-Kapon, Sandra D. Scherer, Ziv Raviv, Emmanuelle Merquiol, Yael Ben-Nun, Valeria Miller, Chen Rachman-Tzemah, Michael Timaner, Yelena Mumblat, Neta Ilan, David Loven, Dov Hershkovitz, Ronit Satchi-Fainaro, Galia Blum, Jonathan P. Sleeman, Israel Vlodavsky, Yuval Shaked
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1344-1356 (2016)
Summary: While chemotherapy strongly restricts or reverses tumor growth, the response of host tissue to therapy can counteract its anti-tumor activity by promoting tumor re-growth and/or metastases, thus limiting therapeutic efficacy. Here, we show t
Externí odkaz:
https://doaj.org/article/33aac968c8234da399706c8ab64ff755
Autor:
Uri Amit, David Kain, Allon Wagner, Avinash Sahu, Yael Nevo‐Caspi, Nir Gonen, Natali Molotski, Tal Konfino, Natalie Landa, Nili Naftali‐Shani, Galia Blum, Emmanuelle Merquiol, Danielle Karo‐Atar, Yariv Kanfi, Gidi Paret, Ariel Munitz, Haim Y. Cohen, Eytan Ruppin, Sridhar Hannenhalli, Jonathan Leor
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)
BackgroundThe immune system plays a pivotal role in myocardial homeostasis and response to injury. Interleukins‐4 and ‐13 are anti‐inflammatory type‐2 cytokines, signaling via the common interleukin‐13 receptor α1 chain and the type‐2 in
Externí odkaz:
https://doaj.org/article/87f0732ac3874443bb7acc9387bf1fb7