Výsledky vyhledávání - "Galen W Radebaugh"

Targeted lymphatic transport and modified systemic distribution of CI-976, a lipophilic lipid-regulator drug, via a formulation approach

Autor: Galen W. Radebaugh, David J. Hauss, Surendra C. Mehta

Publikováno v: International Journal of Pharmaceutics. 108:85-93

CI-976 is a poorly water soluble lipid regulator with good solubility in triglycerides and a high octanol:water partition coefficient. These physicochemieal properties suggest significant lymphatic transport following gastroin-testinal absorption. St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93eae45173351b4864b6d54468852af5
https://doi.org/10.1016/0378-5173(94)90318-2

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Effect of polyvinylpyrrolidone on the crystallinity and dissolution rate of solid dispersions of the antiinflammatory CI-987

Autor: Surendra C. Mehta, Galen W. Radebaugh, Albert S. Kearney, Dawn L. Gabriel

Publikováno v: International Journal of Pharmaceutics. 104:169-174

Solid dispersions of CI-987 (5-{[3,5-bis(l,l-dimethylethyI)-4-hydroxyphcnyl]-methylene}-2,4-thiazolidinedione) having varying concentrations of polyvinylpyrrolidone (PVP K 28–32), were prepared in an attempt to improve the dissolution rate of CI-98

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73de7261ca5c03a4be713cd46cac2d6c
https://doi.org/10.1016/0378-5173(94)90192-9

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Preformulation studies to aid in the development of an injectable formulation of PD 144872, a radiosensitizing anticancer agent

Autor: Albert S. Kearney, Galen W. Radebaugh, Surendra C. Mehta

Publikováno v: International Journal of Pharmaceutics. 102:63-70

PD 144872, the R -enantiomer of α-[[(2-bromoethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanol hydrobromide, is a dual-action hypoxic cell radiosensitizer which is currently being evaluated at the preclinical level. This study was performed to aid i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83b692904e8d3fb7b3f49d98f40aba26
https://doi.org/10.1016/0378-5173(94)90040-x

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[Untitled]

Autor: Thomas Nicholas Julian, Tsun Ming Chen, Amal M. Boctor, Anne B. Giordani, Galen W. Radebaugh, Scott C. Wootton, Richard I. Senderoff

Publikováno v: Pharmaceutical Research. 11:1712-1720

Human epidermal growth factor 1-48 (hEGF 1-48, Des(49-53)hEGF) is a single chain polypeptide (48 amino acids; 3 disulfide bonds; 5445 Da) possessing a broad spectrum of biologic activity including the stimulation of cell proliferation and tissue grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d79f90bc8a9a40a3f9f8031cd6a758b6
https://doi.org/10.1023/a:1018903014204

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[Untitled]

Autor: Galen W. Radebaugh, Paul E. Luner, Suresh R. Babu

Publikováno v: Pharmaceutical Research. 11:1755-1760

Physicochemical effects caused by intestinal fluids on drugs in the gastrointestinal (GI) tract can be a contributing factor in food induced changes in bioavailability. To identify physicochemical properties of gemfibrozil that may be altered by endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91176929565dfb46b25733ce0c8038a1
https://doi.org/10.1023/a:1018967401000

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Isolation and structure of homotemsirolimuses A, B, and C

Autor: Ker Yu, Galen W. Radebaugh, Thomas G Pagano, Fangming Kong, Parimal Desai, Mahdi B. Fawzi, Tianmin Zhu

Publikováno v: Journal of natural products. 74(4)

Homotemsirolimuses A, B, and C (2a, 2b, 2c) were found to be minor components of a temsirolimus preparation made from rapamycin. These three temsirolimus analogues are derived from the corresponding rapamycin analogues, homorapamycins A, B, and C (1a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c646183a41c81fbf40832212d2676ee
https://pubmed.ncbi.nlm.nih.gov/21438579

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The effect of structural changes on the intramolecular degradation of the ‘dipeptoid’ CI-988

Autor: Surendra C. Mehta, Galen W. Radebaugh, Albert S. Kearney

Publikováno v: International Journal of Pharmaceutics. 92:63-70

CI-988 ([ R-(R∗,R∗)]-4-[[2-[[3-(1H-indol-3-yl)-2- methyl -1- oxo -2-[[( tricyclo [3.3.1.1 3,7 ] dec -2- yloxy )carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid) is a selective, ‘dipeptoid’, cholecystokinin B receptor antag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8315e341c569d8b1880ee4909bf7fad
https://doi.org/10.1016/0378-5173(93)90264-g

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[Untitled]

Autor: Galen W. Radebaugh, Lee F. Crawford, Surendra C. Mehta, Albert S. Kearney

Publikováno v: Pharmaceutical Research. 10:1461-1465

The pH dependence of the interconversion kinetics, equilibrium, and solubilities of the lactone and hydroxyacid forms of the HMG-CoA reductase inhibitor, CI-981 ([R-(R*,R*)]-2-(4-fluorophenyl)- beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e3dee2b40c78844817872464ed55fc0
https://doi.org/10.1023/a:1018923325359

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