Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Galen Rask"'
1
Akademický článek
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome
Autor: Claire Bryant, Galen Rask, Amanda P. Waller, Amy Webb, Marina R. Galdino-Pitta, Angelica A. Amato, Rachel Cianciolo, Rajgopal Govindarajan, Brian Becknell, Bryce A. Kerlin, Francisco A.R. Neves, Alessia Fornoni, Shipra Agrawal
Publikováno v: iScience, Vol 25, Iss 4, Pp 104001- (2022)
Summary: Glomerular disease manifests as nephrotic syndrome (NS) with high proteinuria and comorbidities, and is frequently refractory to standard treatments. We hypothesized that a selective modulator of PPARγ, GQ-16, will provide therapeutic advan
Externí odkaz: https://doaj.org/article/44c5e6b650c949c28445ae97cc0f1fae
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3
Akademický článek
Roles of the TRAPP-II Complex and the Exocyst in Membrane Deposition during Fission Yeast Cytokinesis.
Autor: Ning Wang, I-Ju Lee, Galen Rask, Jian-Qiu Wu
Publikováno v: PLoS Biology, Vol 14, Iss 4, p e1002437 (2016)
The cleavage-furrow tip adjacent to the actomyosin contractile ring is believed to be the predominant site for plasma-membrane insertion through exocyst-tethered vesicles during cytokinesis. Here we found that most secretory vesicles are delivered by
Externí odkaz: https://doaj.org/article/076f89104b0c4a8cb34734655d7844b0
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4
Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma
Autor: E. John Tokarsky, Jesse C. Crow, Lillian M. Guenther, John Sherman, Cenny Taslim, Gabriela Alexe, Kathleen I. Pishas, Galen Rask, Blake S. Justis, Ana Kasumova, Kimberly Stegmaier, Stephen L. Lessnick, Emily R. Theisen
Publikováno v: Molecular cancer research : MCR. 20(7)
Expression of the fusion oncoprotein EWS/FLI causes Ewing sarcoma, an aggressive pediatric tumor characterized by widespread epigenetic deregulation. These epigenetic changes are targeted by novel lysine-specific demethylase-1 (LSD1) inhibitors, whic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d5a5995d217e1886fa3ab5debdd6c0
https://pubmed.ncbi.nlm.nih.gov/35298000
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5
Mitochondrial Dysfunction is a Driver for SP-2509 Drug Resistance in Ewing Sarcoma
Autor: E. John Tokarsky, Jesse C. Crow, Lillian M. Guenther, John Sherman, Cenny Taslim, Gabriela Alexe, Kathleen I. Pishas, Galen Rask, Blake S. Justis, Ana Kasumova, Kimberly Stegmaier, Stephen L. Lessnick, Emily R. Theisen
Expression of the fusion oncoprotein EWS/FLI causes Ewing sarcoma, an aggressive pediatric tumor characterized by widespread epigenetic deregulation. These epigenetic changes are targeted by novel lysine specific demethylase-1 (LSD1) inhibitors, whic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35016619fcdd3688e3895a8185c06a43
https://doi.org/10.1101/2021.12.13.472459
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7
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome
Autor: Claire Bryant, Galen Rask, Amanda P. Waller, Amy Webb, Marina R. Galdino-Pitta, Angelica A. Amato, Rachel Cianciolo, Rajgopal Govindarajan, Brian Becknell, Bryce A. Kerlin, Francisco A.R. Neves, Alessia Fornoni, Shipra Agrawal
Publikováno v: iScience. 25(4)
Glomerular disease manifests as nephrotic syndrome (NS) with high proteinuria and comorbidities, and is frequently refractory to standard treatments. We hypothesized that a selective modulator of PPARγ, GQ-16, will provide therapeutic advantage over
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803ff6025d39f6a22b834262e3cbed35
https://pubmed.ncbi.nlm.nih.gov/35310946
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8
Abstract P087: Targeting LSD1 protein scaffolding function in FET-rearranged sarcomas with SP-2577
Autor: Galen Rask, Emily R. Theisen, Aundrietta D. Duncan, Daniela Y. Santiesteban
Publikováno v: Molecular Cancer Therapeutics. 20:P087-P087
The RNA-binding proteins, FUS, EWSR1, and TAF15 (FET protein family) are frequently fused to transcription factors, and the resulting oncogenic fusion proteins characterize various sarcomas. These fusion proteins act as aberrant transcription factors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ba6454fa2f45d7a15ae25d763368ea6
https://doi.org/10.1158/1535-7163.targ-21-p087
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9
Selective Modulator of Nuclear Receptor PPARγ with Reduced Adipogenic Potential Ameliorates Experimental Nephrotic Syndrome
Autor: Bryce A. Kerlin, Amanda P. Waller, Claire Burton, Shipra Agrawal, Angélica Amorim Amato, Rachel E. Cianciolo, Alessia Fornoni, Marina R. Galdino-Pitta, Francisco de Assis Rocha Neves, Amy Webb, Galen Rask, Brian Becknell
Publikováno v: SSRN Electronic Journal.
Background: Glomerular disease, often manifesting as nephrotic syndrome (NS) with high proteinuria, can be refractory to standard treatment and is typically associated with hypoalbuminemia, hypercholesterolemia and hypercoagulopathy. We hypothesized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b3b3eb6f2fcbde22a1117052462815d
https://doi.org/10.2139/ssrn.3912943
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10
Roles of the TRAPP-II Complex and the Exocyst in Membrane Deposition during Fission Yeast Cytokinesis
Autor: Galen Rask, I-Ju Lee, Ning Wang, Jian-Qiu Wu
Publikováno v: PLoS Biology
PLoS Biology, Vol 14, Iss 4, p e1002437 (2016)
The cleavage-furrow tip adjacent to the actomyosin contractile ring is believed to be the predominant site for plasma-membrane insertion through exocyst-tethered vesicles during cytokinesis. Here we found that most secretory vesicles are delivered by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545fa657881d532a6ee8f79d615b5e6e
https://doi.org/10.1371/journal.pbio.1002437
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