Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Galen E B Wright"'
Autor:
Alana N. Slike, Galen E. B. Wright
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/8a172cff023d4cfeac8de399d4733d33
Autor:
Erika N. Scott, Galen E. B. Wright, Britt I. Drögemöller, Jafar S. Hasbullah, Erandika P. Gunaretnam, Fudan Miao, Amit P. Bhavsar, Fei Shen, Bryan P. Schneider, Bruce C. Carleton, Colin J. D. Ross
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Anthracyclines are highly effective chemotherapeutic agents; however, their clinical utility is limited by severe anthracycline-induced cardiotoxicity (ACT). Genome-wide association studies (GWAS) have uncovered several genetic variants asso
Externí odkaz:
https://doaj.org/article/ef67d46dd6034a2687778555b536d940
Autor:
Frederick A. Zeiler, Yasser Iturria-Medina, Eric P. Thelin, Alwyn Gomez, Jai J. Shankar, Ji Hyun Ko, Chase R. Figley, Galen E. B. Wright, Chris M. Anderson
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Despite changes in guideline-based management of moderate/severe traumatic brain injury (TBI) over the preceding decades, little impact on mortality and morbidity have been seen. This argues against the “one-treatment fits all” approach to such m
Externí odkaz:
https://doaj.org/article/2356017c859740138a4a2265656359c2
Autor:
Jorge E. B. da Rocha, Houcemeddine Othman, Gerrit Botha, Laura Cottino, David Twesigomwe, Samah Ahmed, Britt I. Drögemöller, Faisal M. Fadlelmola, Philip Machanick, Mamana Mbiyavanga, Sumir Panji, Galen E. B. Wright, Clement Adebamowo, Mogomotsi Matshaba, Michéle Ramsay, Gustave Simo, Martin C. Simuunza, Caroline T. Tiemessen, Sandra Baldwin, Mathias Chiano, Charles Cox, Annette S. Gross, Pamela Thomas, Francisco-Javier Gamo, Scott Hazelhurst
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Introduction: Investigating variation in genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic (PGx) relationships. ADME gene variation is relatively well characterized in
Externí odkaz:
https://doaj.org/article/99ceb47f7191413f978d2697836a9538
Autor:
Catrina M. Loucks, Jennifer J. Lin, Jessica N. Trueman, Britt I. Drögemöller, Galen E. B. Wright, Wan‐Chun Chang, Kathy H. Li, Eric M. Yoshida, Jo‐Ann Ford, Samuel S. Lee, Pam Crotty, Richard B. Kim, Bandar Al‐Judaibi, Ute I. Schwarz, Alnoor Ramji, Jeanette F. Farivar, Edward Tam, Lori Lee Walston, Colin J. D. Ross, Bruce C. Carleton
Publikováno v:
Liver International. 42:796-808
According to pivotal clinical trials, cure rates for sofosbuvir-based antiviral therapy exceed 96%. Treatment failure is usually assumed to be because of virological resistance-associated substitutions or clinical risk factors, yet the role of patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465b554b7658b273b9d5cc50cce82eae
https://doi.org/10.1111/liv.15175
https://doi.org/10.1111/liv.15175
Autor:
Azra Siddiqui, Galen E B Wright, Scott Hazelhurst, Zané Lombard, David Twesigomwe, Jorge da Rocha, Britt I. Drögemöller
Publikováno v:
Clinical Pharmacology & Therapeutics. 110:741-749
Bioinformatics pipelines for calling star alleles (haplotypes) in cytochrome P450 (CYP) genes are important for the implementation of precision medicine. Genotyping CYP genes using high throughput sequencing data is complicated, e.g., by being highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8dcfba201d191676f6d42e25fc63e76
https://doi.org/10.1002/cpt.2173
https://doi.org/10.1002/cpt.2173
Autor:
Eric M. Yoshida, Britt I. Drögemöller, Jessica N. Trueman, Samuel S. Lee, Catrina M Loucks, Jennifer J. Lin, Bandar Al-Judaibi, Colin J. D. Ross, Alnoor Ramji, Jo-Ann Ford, Bruce Carleton, Ute I. Schwarz, Richard B. Kim, Galen E B Wright, Edward Tam
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 143, Iss, Pp 112195-(2021)
Paediatrics Publications
Paediatrics Publications
Background The current use of ribavirin in difficult-to-cure chronic hepatitis C patients (HCV) and patients with severe respiratory infections is constrained by the issue of ribavirin-induced hemolytic anemia that affects 30% of treated patients, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e004663a21b88b2e96a5b17e62abaaae
http://www.sciencedirect.com/science/article/pii/S0753332221009793
http://www.sciencedirect.com/science/article/pii/S0753332221009793
Autor:
David Twesigomwe, Scott Hazelhurst, Britt I. Drögemöller, Galen E B Wright, Zané Lombard, Jorge da Rocha
Publikováno v:
NPJ Genomic Medicine
npj Genomic Medicine, Vol 5, Iss 1, Pp 1-11 (2020)
npj Genomic Medicine, Vol 5, Iss 1, Pp 1-11 (2020)
Genetic variation in genes encoding cytochrome P450 enzymes has important clinical implications for drug metabolism. Bioinformatics algorithms for genotyping these highly polymorphic genes using high-throughput sequence data and automating phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2240dfb1079a8c93be390198c8ad33aa
https://doi.org/10.1038/s41525-020-0135-2
https://doi.org/10.1038/s41525-020-0135-2
Autor:
Houcemeddine Othman, Sandra Baldwin, Clement Adebamowo, Britt I. Drögemöller, Pamela Thomas, Charles D. Cox, Annette S. Gross, Jorge da Rocha, Samah Ahmed, Gustave Simo, Caroline T. Tiemessen, Sumir Panji, Martin Simuunza, Laura Cottino, Mamana Mbiyavanga, Gerrit Botha, Francisco-Javier Gamo, Michèle Ramsay, Mathias Chiano, Mogomotsi Matshaba, David Twesigomwe, Scott Hazelhurst, Philip Machanick, Faisal M. Fadlelmola, Galen E B Wright
Investigating variation in genes involved in theabsorption, distribution, metabolism, andexcretion(ADME) of drugs are key to characterising pharmacogenomic (PGx) relationships. ADME gene variation is relatively well characterised in European and Asia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82b013e9e9ad7659baf51229d717779f
https://doi.org/10.1101/2020.06.14.108217
https://doi.org/10.1101/2020.06.14.108217
Autor:
Britt I, Drögemöller, Galen E B, Wright, Joanne, Shih, Jose G, Monzon, Karen A, Gelmon, Colin J D, Ross, Ursula, Amstutz, Bruce C, Carleton, Folefac, Aminkeng
Publikováno v:
Drögemöller, Britt I; Wright, Galen E B; Shih, Joanne; Monzon, Jose G; Gelmon, Karen A; Ross, Colin J D; Amstutz, Ursula; Carleton, Bruce C (2019). CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines. Breast cancer research and treatment, 173(3), pp. 521-532. Springer 10.1007/s10549-018-5027-0
PURPOSE Tamoxifen is one of the principal treatments for estrogen receptor (ER)-positive breast cancer. Unfortunately, between 30 and 50% of patients receiving this hormonal therapy relapse. Since CYP2D6 genetic variants have been reported to play an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dad020a39cb572c53c53ed17d7487b
https://doi.org/10.1007/s10549-018-5027-0
https://doi.org/10.1007/s10549-018-5027-0