Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gale Hansen"'
Autor:
Yanyun Liu, Kenny Tsang, Michelle Mays, Gale Hansen, Jeffrey Chiecko, Maureen Crames, Yangjie Wei, Weijie Zhou, Chase Fredrick, James Hu, Dongmei Liu, Douglas Gebhard, Zhong-Fu Huang, Akshita Datar, Anthony Kronkaitis, Kristina Gueneva-Boucheva, Daniel Seeliger, Fei Han, Saurabh Sen, Srinath Kasturirangan, Justin M. Scheer, Andrew E. Nixon, Tadas Panavas, Michael S. Marlow, Sandeep Kumar
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Biotherapeutic optimization, whether to improve general properties or to engineer specific attributes, is a time-consuming process with uncertain outcomes. Conversely, Consensus Protein Design has been shown to be a viable approach to enhance protein
Externí odkaz:
https://doaj.org/article/4c91351f25cc410584aa768aeb4853a4
Autor:
Sven Mostböck, Helen Haixia Wu, Timothy Fenn, Bettina Riegler, Susanne Strahlhofer, Yining Huang, Gale Hansen, Rachel Kroe-Barrett, Iñigo Tirapu, Anne B. Vogt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
VISTA (PD-1H) is an immune regulatory molecule considered part of the next wave of immuno-oncology targets. VISTA is an immunoglobulin (Ig) superfamily cell surface molecule mainly expressed on myeloid cells, and to some extent on NK cells and T cell
Externí odkaz:
https://doaj.org/article/022e32f65a2647d7bed1c6f04da17b57
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 385:214-221
Autor:
Michael Dziegelewski, David Presky, Susan van Tongeren, Steve Fogal, Rachel Kroe-Barrett, Helen Wu, Sanjaya Singh, Tobias Litzenberger, Scott Brodeur, Gale Hansen, Christine Grimaldi, Eliud Sepuldeva, Zhong-Fu Huang, Dongmei Liu, Hua Li, Kerry-Leigh Ralph, Lee Frego, Jennifer Ahlberg
Publikováno v:
International Journal of Pharmaceutics. 609:121162
Antibodies targeting the CD40-CD40L pathway have great potential for treating autoimmune diseases like rheumatoid arthritis, systemic lupus erythematosus (SLE), lupus nephritis (LN), and inflammatory bowel diseases (IBD). However, in addition to the
Publikováno v:
Metabolic Syndrome and Related Disorders. 5:297-304
Patients with essential hypertension and the spontaneously hypertensive rat (SHR) are insulin-resistant and hyperinsulinemic. These findings suggest the possibility that insulin resistance and hyperinsulinemia may play a pivotal role in blood pressur
Publikováno v:
Alcoholism: Clinical and Experimental Research. 21:122-127
Therapeutic observations suggest that azidothymidine (AZT)-resistant HIV+/AIDS patients are frequently offered AZT/dideoxycytidine (DDC) or dideoxyinosine (DDI) therapy. The latter therapies have been associated with the development of acute pancreat
Autor:
Patricia Giblin, Gale Hansen, Kerry L. M. Ralph, Maret Panzenbeck, Jeanne Magram, Catrin Pracht, Rachel Kroe-Barrett, Racheline Schwartz, Sandra Miller, Clare Zimmitti, Rainer Boxhammer, Sudha Desai, John Ksiazek, Tobias Litzenburger
Publikováno v:
Human antibodies. 20(3-4)
PAR-2 belongs to a family of G-protein coupled Protease-Activated Receptors (PAR) which are activated by specific proteolytic cleavage in the extracellular N-terminal region. PAR-2 is activated by proteases such as trypsin, tryptase, proteinase 3, fa
Autor:
Edward Leon Barsoumian, Isamu Akiba, Bachir Latli, Kinu Kameda, Annette Tibolla, Saisoku Ueda, Scott Jakes, Vladimir Papov, Richard H. Ingraham, Gale Hansen, Eustratios Bananis, John R. Proudfoot
Publikováno v:
The FASEB Journal. 22
Autor:
E. Musvasva, Kathy O’Shea, Rachel Kroe-Barrett, Haixia Wu, D. Blanset, Sudha Desai, Kerry L. M. Ralph, Jennifer Ahlberg, Hua Li, Keith Canada, Steven E. Fogal, Gerald Nabozny, Gale Hansen, S. VanTongeren, Zhu Xiangyang, Elizabeth Mainolfi, Meera Ramanujam, Amy Marie Nicoletti, Sanjaya Singh, Christine Grimaldi, Brodeur Scott, S. Cannan
Publikováno v:
Annals of the Rheumatic Diseases. 74:344.1-344
Background Costimulatory molecule pair CD40-CD40L plays a central role not only in immune cell interactions but also in immune-non immune cell activation. Targeting this pathway has generated great interest but early attempts to target CD40L failed m
Autor:
John W. Grinsell, Arthur L.M. Swislocki, Jeffrey S. Sare, Claude K. Lardinois, Jason R. Michaels, Raymond Gonzalez, Gale Hansen Starich
Publikováno v:
American journal of hypertension. 13(4 Pt 1)
Subjects with hypertension are hyperinsulinemic and resistant to insulin-stimulated glucose uptake. A similar paradigm is found in the spontaneously hypertensive rat (SHR). These findings suggest the possibility that insulin resistance and hyperinsul