Design and rationale of a pragmatic randomized clinical trial of early dronedarone versus usual care to change and improve outcomes in persons with first-detected atrial fibrillation – the CHANGE AFIB study

Autor: Pokorney, Sean D., Nemeth, Hayley, Chiswell, Karen, Albert, Christine, Allyn, Nadine, Blanco, Rosalia, Butler, Javed, Calkins, Hugh, Elkind, Mitchell S.V., Fonarow, Gregg C., Fontaine, John M., Frankel, David S., Fermann, Gregory J., Gale, Rex, Kalscheur, Matthew, Kirchhof, Paulus, Koren, Andrew, Miller, Joseph B., Rashkin, Jason, Russo, Andrea M., Rutan, Christine, Steinberg, Benjamin A., Piccini, Jonathan P.

Publikováno v: In American Heart Journal January 2025 279:66-75

Design and rationale of a pragmatic randomized clinical trial of early dronedarone versus usual care to change and improve outcomes in persons with first-detected atrial fibrillation - the CHANGE AFIB study.

Autor: Pokorney SD; Duke Clinical Research Institute, Durham, NC; Duke Heart Center, Duke University Medical Center, Durham, NC., Nemeth H; Duke Clinical Research Institute, Durham, NC; Duke Heart Center, Duke University Medical Center, Durham, NC., Chiswell K; Duke Clinical Research Institute, Durham, NC., Albert C; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA., Allyn N; American Heart Association, Dallas, TX., Blanco R; Duke Clinical Research Institute, Durham, NC., Butler J; Baylor Scott and White Research Institute, Dallas, TX; Department of Medicine, University of Mississippi Medical Center, Jackson, MS., Calkins H; Johns Hopkins Hospital, Baltimore, MD., Elkind MSV; American Heart Association, Dallas, TX., Fonarow GC; Division of Cardiology, Ronald Reagan-UCLA Medical Center, Los Angeles, CA., Fontaine JM; Drexel University College of Medicine, Philadelphia, PA., Frankel DS; Cardiovascular Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA., Fermann GJ; Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH., Gale R; Hilton Head Island Leadership Institute, Hilton Head, SC., Kalscheur M; Department of Medicine, University of Wisconsin, Madison, WI., Kirchhof P; Department of Cardiology, University Heart and Vascular Center UKE Hamburg, Germany; German Center of Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Germany; Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK., Koren A; Sanofi, Bridgewater, NJ., Miller JB; Department of Emergency Medicine, Wayne State University & Henry Ford Hospital, Detroit, MI., Rashkin J; Sanofi, Bridgewater, NJ., Russo AM; Division of Cardiovascular Disease, Cooper Medical School of Rowan University, Camden, NJ., Rutan C; American Heart Association, Dallas, TX., Steinberg BA; Department of Medicine, University of Utah, Salt Lake City, UT., Piccini JP; Duke Clinical Research Institute, Durham, NC; Duke Heart Center, Duke University Medical Center, Durham, NC. Electronic address: jonathan.piccini@duke.edu.

Publikováno v: American heart journal [Am Heart J] 2024 Oct 16; Vol. 279, pp. 66-75. Date of Electronic Publication: 2024 Oct 16.