Výsledky vyhledávání - "Galdino-Pitta"

Akademický článek

Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome

Autor: Claire Bryant, Galen Rask, Amanda P. Waller, Amy Webb, Marina R. Galdino-Pitta, Angelica A. Amato, Rachel Cianciolo, Rajgopal Govindarajan, Brian Becknell, Bryce A. Kerlin, Francisco A.R. Neves, Alessia Fornoni, Shipra Agrawal

Publikováno v: iScience, Vol 25, Iss 4, Pp 104001- (2022)

Summary: Glomerular disease manifests as nephrotic syndrome (NS) with high proteinuria and comorbidities, and is frequently refractory to standard treatments. We hypothesized that a selective modulator of PPARγ, GQ-16, will provide therapeutic advan

Externí odkaz: https://doaj.org/article/44c5e6b650c949c28445ae97cc0f1fae

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Akademický článek

Ability of two new thiazolidinediones to downregulate proinflammatory cytokines in peripheral blood mononuclear cells from children with asthma

Autor: Moacyr Jesus Barreto de Melo Rêgo, Adriana Azoubel-Antunes, Mariana Brayner-Cavalcanti Freire Bezerra, Michelly Cristiny Pereira, Juliana Cruz da Silva, Thiago Ubiratan Lins e Lins, Emanuel Sávio Cavalcanti Sarinho, Cézar Augusto da Cruz Amorim, Maria do Carmo Alves de Lima, Marina Rocha Galdino-Pitta, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 54, Iss 3 (2018)

Allergic asthma is a chronic, complex inflammatory disease of the airway. Despite extensive studies on the immunomodulation of T helper (Th) cell pathways (i.e., Th1 and Th2) in asthma, little is known about the effects of Th17 pathway modulation, pa

Externí odkaz: https://doaj.org/article/3f9ff315621a42929eec2f36e4a96881

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Synthesis and biological activities of new phthalimide and thiazolidine derivatives

Autor: Marina R. Galdino-Pitta, André Silva Lira de Lucena, Douglas Carvalho Francisco Viana, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta, Marcel L. Almeida, Flaviana Alves dos Santos, Michelly Cristiny Pereira, Vitor A. S. Silva, Moacyr Jesus Barreto de Melo Rêgo

Publikováno v: Medicinal Chemistry Research. 31:108-119

The combination of pharmacophoric nuclei with different targets has been a strategy for the development of new drugs aimed at improving cancer treatment. A series of ten novel phthalimido-thiazolidine-2-4-dione derivatives were synthesized by two dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::787caeeb97bb28aacffd0ce92ea3340d
https://doi.org/10.1007/s00044-021-02821-7

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Ischemia-reperfusion damage is attenuated by GQ-11, a peroxisome proliferator-activated receptor (PPAR)-α/γ agonist, after aorta clamping in rats

Autor: Jacqueline Cavalcante Silva, Margherita Bavestrello, Valerio Gazzola, Giovanni Spinella, Bianca Pane, Elena Grasselli, Ilaria Demori, Laura Canesi, Laura Emionite, Michele Cilli, Ambra Buschiazzo, Gianmario Sambuceti, Ivan Rocha Pitta, Marina Galdino Pitta, Patrizia Perego, Domenico Palombo, Dulcineia Saes Parra Abdalla

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Ischemia-Reperfusion (I/R) damage is one of the major challenges in cardiothoracic surgeries and in a pathological manner, is identified by exacerbated damage signals resulted from blood supply restriction and subsequent flow restoration and re‑oxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48515d062a1bf1d3842feb6e4c138be

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Selective Modulator of Nuclear Receptor PPARγ with Reduced Adipogenic Potential Ameliorates Experimental Nephrotic Syndrome

Autor: Galen Rask, Alessia Fornoni, Marina R. Galdino-Pitta, Brian Becknell, Angélica Amorim Amato, Amanda P. Waller, Claire Burton, Francisco de Assis Rocha Neves, Shipra Agrawal, Rachel E. Cianciolo, Bryce A. Kerlin, Amy Webb

BackgroundGlomerular disease, often manifesting as nephrotic syndrome (NS) with high proteinuria, can be refractory to standard treatment and is typically associated with hypoalbuminemia, hypercholesterolemia and hypercoagulopathy. We hypothesized th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8b2868f1e4769e8d63e12a803ac5c88
https://doi.org/10.1101/2021.09.14.459479

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Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome

Publikováno v: iScience. 25(4)

Glomerular disease manifests as nephrotic syndrome (NS) with high proteinuria and comorbidities, and is frequently refractory to standard treatments. We hypothesized that a selective modulator of PPARγ, GQ-16, will provide therapeutic advantage over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803ff6025d39f6a22b834262e3cbed35
https://pubmed.ncbi.nlm.nih.gov/35310946

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