Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Galakatos Nicholas G"'
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 66(Pt 2)
The anaphylatoxin C5a is derived from the complement component C5 during activation of the complement cascade. It is an important component in the pathogenesis of a number of inflammatory diseases. NMR structures of human and porcine C5a have been re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a71bfffc6100fe230a3eecf5710107f
https://pubmed.ncbi.nlm.nih.gov/20124699
https://pubmed.ncbi.nlm.nih.gov/20124699
Autor:
James Wasvary, Isidoros Vlattas, James L. Stanton, Albert Braunwalder, Bruce Seligmann, Matthew A. Sills, James Dellureficio, Galakatos Nicholas G, Richard Kramer, Iou Iou Sytwu
Publikováno v:
Journal of medicinal chemistry. 37(17)
In order to identify regions of C5a that contribute to receptor binding and functional activity of the anaphylatoxin, a series of peptides was synthesized in which core segments have been attached to C-terminal segments via native peptidic or disulfi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf174e45d8bc5402c1b7b002aa085f
https://pubmed.ncbi.nlm.nih.gov/8064805
https://pubmed.ncbi.nlm.nih.gov/8064805
Autor:
Galakatos Nicholas G, Matthew J. Toth, William O. Haston, Matthew A. Sills, Donna R. Yarwood, Bruce Seligmann, Albert Braunwalder, William C. Boyar, Leslie Huwyler, Joseph T. Hadala
We have determined which amino acids contribute to the pharmacophore of human C5a, a potent inflammatory mediator. A systematic mutational analysis of this 74-amino acid protein was performed and the effects on the potency of receptor binding and of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77975a36b4e3a2a39e16669dc49efbe
https://europepmc.org/articles/PMC2142918/
https://europepmc.org/articles/PMC2142918/
Autor:
Galakatos, Nicholas G.
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1984
Includes bibliographical references.
by Nicholas G. Galakatos.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Chemistry
Includes bibliographical references.
by Nicholas G. Galakatos.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Chemistry
Externí odkaz:
https://hdl.handle.net/1721.1/131204
Autor:
GALAKATOS, Nicholas G., HANCOCK, John E. H., MORGAN, Olwen M., ROBERTS, Michael R., WALLACE, Jeffrey K.
Publikováno v:
Synthesis; January 1978, Vol. 1978 Issue: 6 p472-474, 3p