Výsledky vyhledávání - "Gal Ben David"

Discovery of potent molecular chimera (CM358) to treat human metastatic melanoma

Autor: Galia Luboshits, Gary Gellerman, Refael Minnes, Helena Tuchinsky, Gal Ben-David, A. Gancz, Yosi Gilad, Hanoch Senderowitz, Michael A. Firer

Publikováno v: European journal of medicinal chemistry. 138

The resistance of cancer cells to chemotherapeutic agents, whether through intrinsic mechanisms or developed resistance, motivates the search for new chemotherapeutic strategies. In the present report, we demonstrate a facile synthetic strategy towar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4e806cf5c39a0b9cb95c2dff88c2df
https://pubmed.ncbi.nlm.nih.gov/28710962

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Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold

Autor: Gary A. Weisman, Bilha Fischer, Jean Sévigny, Gal Ben-David, Yael Nadel, Georg Reiser, Jean M. Camden, Yocheved Gilad, Hanoch Senderowitz, Daniel Förster, Sarah Kenigsberg, Joanna Lecka

Publikováno v: Journal of medicinal chemistry. 57(11)

Aberrant nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) activity is associated with chondrocalcinosis, osteoarthritis, and type 2 diabetes. The potential of NPP1 inhibitors as therapeutic agents, and the scarceness of their structure-activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456bc78feda89c1466f3abb72a115d10
https://pubmed.ncbi.nlm.nih.gov/24846781

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Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study

Autor: Bilha Fischer, Jean Sévigny, Joanna Lecka, Jocelyn Oscar, Gal Ben-David, Hanoch Senderowitz, Julie Pelletier, Patrick Luyindula, Luba Simhaev, Shay Eliahu

Publikováno v: Journal of medicinal chemistry. 56(21)

Elevated nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) activity is implicated in health disorders including pathological calcification. Specific NPP1 inhibitors would therefore be valuable for studying this enzyme and as potential therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ffdb1f95bfa97012ef9d8942d4c90a
https://pubmed.ncbi.nlm.nih.gov/24083941

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Can myometrial electrical activity identify patients in preterm labor?

Autor: Ilan Calderon, Ram Kerner, Orli Most, Oded Langer, Gal Ben David

Publikováno v: American journal of obstetrics and gynecology. 199(4)

Objective The objective of the study was to determine whether myometrial electrical activity can differentiate false from true preterm labor. Study Design Electrical uterine myography (EUM) was measured prospectively on 87 women, gestational age less

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9a01fdd8dbfa1d66b6dbd7fa0278bb
https://pubmed.ncbi.nlm.nih.gov/18928979

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