Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gakuhei Son"'
Publikováno v:
Gastroenterology Research and Practice, Vol 2010 (2010)
Emerging evidence suggests a strong interaction between the gut microbiota and health and disease. The interactions of the gut microbiota and the liver have only recently been investigated in detail. Receiving approximately 70% of its blood supply fr
Externí odkaz:
https://doaj.org/article/17fb1d69e0444ac48611ef146274e8f1
Autor:
Giulia Manzini, Michael Kremer, Ian N. Hines, Gakuhei Son, Sherri M. Moore, Michael D. Wheeler, Amber Norris, Kun Zhang
Publikováno v:
Transplant International. 27:748-758
Liver regeneration is vital for graft survival and adequate organ function. Smad activation regulates hepatocyte proliferation and macrophage function. The aim of the current study was to evaluate the impact of Smad3 signaling during liver regenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a4a25932ba3726c2218766a9580c4f
https://doi.org/10.1111/tri.12322
https://doi.org/10.1111/tri.12322
Autor:
Yugo Uda, Jiro Fujimoto, Junichi Yamanaka, Yuji Iimuro, Tadamichi Hirano, Shigeki Arii, Gakuhei Son, Akira Mori, Naoki Uyama
Publikováno v:
Surgery. 153:70-77
Background Recent studies of hepatic regeneration have mainly focused on the growth of parenchymal cells. However, remodeling of liver vessels seems to be crucial during hepatic regeneration. In this study, we investigated the influence of antiangiog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01659c53a60d6e1105ead96536ee6a06
https://doi.org/10.1016/j.surg.2012.06.021
https://doi.org/10.1016/j.surg.2012.06.021
Autor:
Jiro Fujimoto, Kenji Nakanishi, Ekihiro Seki, Tetsuji Naka, Tadamitsu Kishimoto, Yuji Iimuro, Hiroko Tsutsui, Yuichi Kondo, Gakuhei Son
Publikováno v:
Journal of Hepatology. 48:237-245
Background/Aims As conditional knockout mice for stat3 are impaired in liver regeneration after partial hepatectomy while those for gp130 have defects in early STAT3 phosphorylation but have normal DNA synthesis, late STAT3 phosphorylation induced in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679aa802c525ef5a8600ff5aee7ea08f
https://doi.org/10.1016/j.jhep.2007.08.020
https://doi.org/10.1016/j.jhep.2007.08.020
Autor:
Jiro Fujimoto, Yuji Iimuro, Tsuyoshi Iwasaki, Takehito Imado, Gakuhei Son, Tadamichi Hirano, Yasuhiko Yoshida
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 293:G1114-G1123
Allogeneic bone-marrow transplantation (BMT) can induce a powerful graft-vs.-tumor (GVT) effect not only on hematological malignancies but also on solid tumors. However, graft-vs.-host disease (GVHD) is a major complication of allogeneic BMT. We asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919d66f1459174d9ce4eee4546910afd
https://doi.org/10.1152/ajpgi.00026.2007
https://doi.org/10.1152/ajpgi.00026.2007
Autor:
Jiro Fujimoto, Yuji Iimuro, Gakuhei Son, Toshihiro Nukiwa, Kunio Matsumoto, Ekihiro Seki, Toshikazu Nakamura, Tadamichi Hirano
Publikováno v:
Journal of Hepatology. 45:688-695
Hepatocyte growth factor promotes cancer development through cell motility-promoting and angiogenic effects. NK4, a fragment of hepatocyte growth factor, acts as its receptor antagonist. We assessed effects of NK4 gene therapy against human hepatocel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fc97ff3264ce6556a34b4ce99a704c
https://doi.org/10.1016/j.jhep.2006.04.011
https://doi.org/10.1016/j.jhep.2006.04.011
Autor:
Tetsuji Naka, Jiro Fujimoto, Shizuo Akira, Tadamitsu Kishimoto, Yuji Iimuro, Kenji Nakanishi, Hiroko Tsutsui, Gakuhei Son, Ekihiro Seki
Publikováno v:
Hepatology. 41:443-450
Toll-like receptors (TLRs) act as innate immune signal sensors and play central roles in host defense. Myeloid differentiation factor (MyD) 88 is a common adaptor molecule required for signaling mediated by TLRs. When the receptors are activated, cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5919810a7a7aacbcf391cd023ea252
https://doi.org/10.1002/hep.20603
https://doi.org/10.1002/hep.20603
Publikováno v:
Gastroenterology Research and Practice
Gastroenterology Research and Practice, Vol 2010 (2010)
Gastroenterology Research and Practice, Vol 2010 (2010)
Emerging evidence suggests a strong interaction between the gut microbiota and health and disease. The interactions of the gut microbiota and the liver have only recently been investigated in detail. Receiving approximately 70% of its blood supply fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb399054b84bcf3dc6874176a1401da
https://pubmed.ncbi.nlm.nih.gov/20706692
https://pubmed.ncbi.nlm.nih.gov/20706692
Publikováno v:
Hepatology (Baltimore, Md.). 50(5)
The hepatic stellate cell (HSC) is the primary cell type in the liver responsible for excess collagen deposition during fibrosis. Following a fibrogenic stimulus the cell changes from a quiescent vitamin A–storing cell to an activated cell type ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bca7716d42b6c12766f82a0a3cd70f
https://pubmed.ncbi.nlm.nih.gov/19790269
https://pubmed.ncbi.nlm.nih.gov/19790269
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 293(3)
Sustained hepatic inflammation induced by various causes can lead to liver fibrosis. Transcription factor NF-κB is important in regulating inflammatory responses, especially in macrophages. We presently investigated whether an NF-κB decoy, a synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4530a7a93d203d47f88f0bf97b5859
https://pubmed.ncbi.nlm.nih.gov/17640975
https://pubmed.ncbi.nlm.nih.gov/17640975