Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gaku Ohtomo"'
Autor:
Masanori Kurihara, Tatsuo Mano, Fumihiro Eto, Ikuko Yao, Kenichiro Sato, Gaku Ohtomo, Taro Bannai, Shota Shibata, Hiroyuki Ishiura, Masako Ikemura, Tomoyasu Matsubara, Maho Morishima, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Mitsutoshi Setou, Atsushi Iwata
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 105989- (2023)
Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in the neurons, glial cells, and other somatic cells. Although CGG repeat expansions in NOTCH2NLC have been id
Externí odkaz:
https://doaj.org/article/804e837d61b44f6ab279139ab2c09bff
Autor:
Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Shingo Yamada, Xiaocen Jin, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Kazuhiko Tagawa, Naoki Atsuta, Masahisa Katsuno, Naoki Tomita, Katsutoshi Furukawa, Yuko Saito, Takashi Saito, Ayaka Ichise, Shinsuke Shibata, Hiroyuki Arai, Takaomi Saido, Marius Sudol, Shin-ichi Muramatsu, Hideyuki Okano, Elliott J. Mufson, Gen Sobue, Shigeo Murayama, Hitoshi Okazawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
The precise mechanisms of neuronal cell death in neurodegeneration are not fully understood. Here the authors show that YAP-mediated neuronal necrosis is increased in pre-symptomatic stages of Alzheimer’s disease and intervention to the necrosis re
Externí odkaz:
https://doaj.org/article/f3578dfd2ff148919a9dde2c540ddafd
Autor:
Ryo Ohtomo, Hidehiro Ishikawa, Keita Kinoshita, Kelly K. Chung, Gen Hamanaka, Gaku Ohtomo, Hajime Takase, Christiane D. Wrann, Hiroshi Katsuki, Atsushi Iwata, Josephine Lok, Eng H. Lo, Ken Arai
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Clinical and basic research suggests that exercise is a safe behavioral intervention and is effective for improving cognitive function in cerebrovascular diseases, including subcortical ischemic vascular dementia (SIVD). However, most of the basic re
Externí odkaz:
https://doaj.org/article/9edc09523ab84bf68816a3ad42d52779
Autor:
Masanori Kurihara, Tatsuo Mano, Fumihiro Eto, Ikuko Yao, Kenichiro Sato, Gaku Ohtomo, Taro Bannai, Shota Shibata, Hiroyuki Ishiura, Masako Ikemura, Tomoyasu Matsubara, Maho Morishima, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Mitsutoshi Setou, Atsushi Iwata
Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in the neurons, glial cells, and other somatic cells. Although CGG repeat expansions in NOTCH2NLC have been id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::412d733614a93b187a29ef163270b887
https://doi.org/10.1101/2022.07.08.499227
https://doi.org/10.1101/2022.07.08.499227
Autor:
Gaku Ohtomo, Kanoh Kondo, Katsutoshi Furukawa, Masaaki Waragai, Hidenori Homma, Shinsuke Shibata, Marius Sudol, Shingo Yamada, Hiroyuki Arai, Yuko Saito, Atsushi Iwata, Naoki Atsuta, Xiaocen Jin, Kazuhiko Tagawa, Hikari Tanaka, Ayaka Ichise, Takashi Saito, Masahisa Katsuno, Naoki Tomita, Hideyuki Okano, Kyota Fujita, Shin-ichi Muramatsu, Elliott J. Mufson, Gen Sobue, Hitoshi Okazawa, Shigeo Murayama, Takaomi C. Saido
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
Nature Communications
Nature Communications
The timing and characteristics of neuronal death in Alzheimer’s disease (AD) remain largely unknown. Here we examine AD mouse models with an original marker, myristoylated alanine-rich C-kinase substrate phosphorylated at serine 46 (pSer46-MARCKS),
Autor:
M. Asem Almansour, Takuya Sasaki, Yusuke Sugiyama, Takashi Matsukawa, Jun Mitsui, Yoshio Sakiyama, Ryo Ohtomo, Katsuhisa Ogata, Mizuho Kawai, Wei Qu, Gaku Ohtomo, Shoji Tsuji, Jun Yoshimura, Yasuo Harigaya, Makiko Taira, Ai Huey Tan, Ichizo Nishino, Masaki Tanaka, Yoshihiko Nakazato, Yutaka Kohno, Tatsushi Toda, Satoru Morimoto, Hiroyuki Ishiura, Hisatomo Kowa, Yasushi Shiio, Yuko Saito, Aki Mitsue, Akihiko Mitsutake, Koichiro Doi, Junko Kanda Kikuchi, Hiroyuki Hatsuta, Yuji Takahashi, Shota Shibata, Yuta Suzuki, Shigeo Murayama, Shen-Yang Lim, Yasuo Terao, Atsushi Iwata, Tatsuo Mano, Hidetoshi Date, Yuichiro Shirota, Akitoshi Takeda, Yumi Umeda-Kameyama, Masashi Hamada, Jun Shimizu, Yaeko Ichikawa, Jun Goto, Miho Matsukawa, Jun Shinmi, Shinichi Morishita
Publikováno v:
Nature Genetics. 51:1222-1232
Noncoding repeat expansions cause various neuromuscular diseases, including myotonic dystrophies, fragile X tremor/ataxia syndrome, some spinocerebellar ataxias, amyotrophic lateral sclerosis and benign adult familial myoclonic epilepsies. Inspired b
Autor:
Takeshi Iwatsubo, Shoji Tsuji, Kagari Koshi-Mano, Takeyuki Tsuchida, Hitoshi Okazawa, Xigui Chen, Gaku Ohtomo, Taro Bannai, Tatsushi Toda, Tadafumi Hashimoto, Ryo Ohtomo, Atsushi Iwata, Tatsuo Mano
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Epidemiological studies have shown that atherosclerotic risk factors accelerate the pathological process underlying Alzheimer’s disease (AD) via chronic cerebral hypoperfusion. In this study, we aimed to clarify the mechanisms by which cerebral hyp
Autor:
Hiroki Shiwaku, Meihua Jin, Christian J. F. Bertens, Gaku Ohtomo, Hitoshi Okazawa, Kohei Tsumaki, Gen Sobue, Masaki Sone, Yuki Yoshioka, Takanori Yokota, Aiko Ishiki, Atsushi Iwata, Hikari Tanaka, Kanoh Kondo, Haruhisa Inoue, Naoki Atsuta, Hidenori Homma, Kyota Fujita, Masaaki Waragai, Hiroyasu Akatsu, Xiaocen Jin, Kazuhiko Tagawa, Yong Huang, Katsutoshi Furukawa, Masahisa Katsuno, Hiroyuki Arai
Publikováno v:
Life Science Alliance, 4(7):e202101022. Life Science Alliance LLC
The early-stage pathologies of frontotemporal lobal degeneration (FTLD) remain largely unknown. In VCPT262A-KI mice carrying VCP gene mutation linked to FTLD, insufficient DNA damage repair in neural stem/progenitor cells (NSCs) activated DNA-PK and
Autor:
Mohammad Rashedul Islam, Ryo Ohtomo, Hajime Takase, Gen Hamanaka, Gaku Ohtomo, Keita Kinoshita, Josephine Lok, Atsushi Iwata, Hiroshi Katsuki, Eng H. Lo, Ken Arai, Kazuo Washida, Christiane D. Wrann
Publikováno v:
Transl Stroke Res
Clinical evidence suggests that patients with subcortical ischemic vascular dementia (SIVD) perform better at cognitive tests after exercise. However, the underlying mechanism for this effect is largely unknown. Here, we examined how treadmill exerci
Autor:
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Bertens, Christian J.F., Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota
Publikováno v:
Life Science Alliance; May2021, Vol. 4 Issue 5, p1-23, 23p, 50 Graphs