Effect of obesity on pharmacokinetics of transdermal fentanyl: Single-center retrospective study and animal study.

Autor: Mizuno S; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan., Gake S; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan., Takabayashi M; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan., Ito Y; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan., Sanada H; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan., Sugimoto N; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan., Maeda A; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan., Tamamura T; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan., Sawamoto K; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan., Hara Y; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan., Ohi Y; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan., Tsuji C; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan., Shiomoto Y; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan., Kato Y; Department of Molecular Pharmacotherapeutics, Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan., Fujita A; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan., Shimada T; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan; Department of Clinical Pharmacy and Healthcare Science, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, Kanazawa, Japan., Miyamoto KI; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan., Sai Y; Department of Clinical Pharmacokinetics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan; Department of Hospital Pharmacy, University Hospital, Kanazawa University, Kanazawa, Japan; AI Hospital/Macro Signal Dynamics Research and Development Center, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan. Electronic address: sai-ys@staff.kanazawa-u.ac.jp.

Publikováno v: Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2024 Nov 05; Vol. 60, pp. 101035. Date of Electronic Publication: 2024 Nov 05.