Výsledky vyhledávání

Akademický článek

Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice

Autor: Jiliang Huang, Gaizhen Ru, Jiajia Sun, Luying Sun, Zhiling Li

Publikováno v: Molecular Medicine, Vol 28, Iss 1, Pp 1-15 (2022)

Abstract Background Maternal obesity impairs embryonic developmental potential and significantly increases the risks of metabolic disorders in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnormalities is still poor

Externí odkaz: https://doaj.org/article/5203215d12c74ddfae71ff24867955be

Zobrazit plný text záznamu

Akademický článek

Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos

Autor: Yue Huang, Zhiling Li, En Lin, Pei He, Gaizhen Ru

Publikováno v: Experimental and Molecular Medicine, Vol 53, Iss 11, Pp 1792-1806 (2021)

IVF: Mechanism and correction of increased cancer risk Increased production of ribosomes, the multi-molecular structures inside cells where protein synthesis occurs, is implicated in the enhanced risk of cancer in offspring conceived by in vitro fert

Externí odkaz: https://doaj.org/article/f84694a74b4645d9954964ac38c1c111

Zobrazit plný text záznamu

Akademický článek

High Dosages of Equine Chorionic Gonadotropin Exert Adverse Effects on the Developmental Competence of IVF-Derived Mouse Embryos and Cause Oxidative Stress-Induced Aneuploidy

Autor: En Lin, Zhiling Li, Yue Huang, Gaizhen Ru, Pei He

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2021)

Gonadotropins play vital roles in the regulation of female reproductive ability and fertility. Our study aimed to determine the effects of superovulation induced by increasing doses of equine chorionic gonadotropin [eCG; also referred to as pregnant

Externí odkaz: https://doaj.org/article/6fdde2a2f6a34fda801ac732d1685821

Zobrazit plný text záznamu

Akademický článek

AMPK Activity Contributes to G2 Arrest and DNA Damage Decrease via p53/p21 Pathways in Oxidatively Damaged Mouse Zygotes

Autor: Pei He, Zhiling Li, Feng Xu, Gaizhen Ru, Yue Huang, En Lin, Sanfeng Peng

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

In zygotes, the capacity of G2/M checkpoint and DNA repair mechanisms to respond to DNA damage varies depending on different external stressors. In our previous studies, we found that mild oxidative stress induced a G2/M phase delay in mouse zygotes

Externí odkaz: https://doaj.org/article/e6b393dfd71c41a2a13e17173432eb74

Zobrazit plný text záznamu

Akademický článek

Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model.

Autor: Que Wu, Gaizhen Ru, Wanfen Xiao, Qian Wang, Zhiling Li

Publikováno v: Clinical Science; Oct2023, Vol. 137 Issue 20, p1577-1591, 15p

Zobrazit plný text záznamu

Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos

Autor: Pei He, Yue Huang, Zhiling Li, Gaizhen Ru, En Lin

Publikováno v: Experimental and Molecular Medicine, Vol 53, Iss 11, Pp 1792-1806 (2021)
Experimental & Molecular Medicine

In vitro fertilization (IVF) increases the risk of tumorigenesis in offspring. The increased oxidative damage during IVF may be involved in tumor formation. However, the molecular mechanisms underlying this phenomenon remain largely unclear. Using a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b354548cdb42d1c70d34502f109462a6
https://doaj.org/article/f84694a74b4645d9954964ac38c1c111

Zobrazit plný text záznamu

Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice

Autor: Jiajia Sun, Gaizhen Ru, Zhiling Li, Jiliang Huang, Luying Sun

Publikováno v: Molecular Medicine, Vol 28, Iss 1, Pp 1-15 (2022)
Molecular Medicine

Background Maternal obesity impairs embryonic developmental potential and significantly increases the risks of metabolic disorders in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnormalities is still poorly unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb143a82c60602393780c02e43ce732
https://pubmed.ncbi.nlm.nih.gov/35123389

Zobrazit plný text záznamu

High Dosages of Equine Chorionic Gonadotropin Exert Adverse Effects on the Developmental Competence of IVF-Derived Mouse Embryos and Cause Oxidative Stress-Induced Aneuploidy

Autor: Gaizhen Ru, En Lin, Zhiling Li, Pei He, Yue Huang

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Frontiers in Cell and Developmental Biology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729ba1c0b85d51da828623bf0b3754c5
https://doi.org/10.3389/fcell.2020.609290

Zobrazit plný text záznamu

Response of Mouse Zygotes Treated with Mild Hydrogen Peroxide as a Model to Reveal Novel Mechanisms of Oxidative Stress-Induced Injury in Early Embryos

Autor: Gaizhen Ru, Zhiling Li, Que Wu, Bin Wang, Diting Qian, Man Chen, Yue Huang, Yuting Zhang

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)

Our study aimed to develop embryo models to evaluate the impact of oxidative stress on embryo development. Mouse zygotes, which stayed at G1 phase, were treated with prepared culture medium (containing 0.00, 0.01, 0.02, 0.03, 0.04, 0.05, or 0.1 mM hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f33811766142dc661a31f8ee4ef748

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání