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Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genome.

Autor: Tedbury PR; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA.; Children's Healthcare of Atlanta; Atlanta, GA, USA., Mahboubi D; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA.; Children's Healthcare of Atlanta; Atlanta, GA, USA., Puray-Chavez M; Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine; Columbia, MO, USA.; C.S. Bond Life Sciences Center, University of Missouri; Columbia, MO, USA., Shah R; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA.; Children's Healthcare of Atlanta; Atlanta, GA, USA., Ukah OB; Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine; Columbia, MO, USA.; C.S. Bond Life Sciences Center, University of Missouri; Columbia, MO, USA., Wahoski CC; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA.; Children's Healthcare of Atlanta; Atlanta, GA, USA., Fadel HJ; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine; Aurora, CO, USA., Poeschla EM; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine; Aurora, CO, USA., Gao X; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA.; Children's Healthcare of Atlanta; Atlanta, GA, USA., McFadden WM; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA.; Children's Healthcare of Atlanta; Atlanta, GA, USA., Gaitanidou M; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA.; Children's Healthcare of Atlanta; Atlanta, GA, USA., Kesesidis N; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA.; Children's Healthcare of Atlanta; Atlanta, GA, USA., Kirby KA; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA.; Children's Healthcare of Atlanta; Atlanta, GA, USA., Vanderford TH; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory Vaccine Center, Emory University; Atlanta, GA, USA., Kvaratskhelia M; Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine; Aurora, CO, USA., Achuthan V; Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute; Boston, MA, USA., Behrens RT; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, WI, USA., Engelman AN; Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute; Boston, MA, USA., Sarafianos SG; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA.; Children's Healthcare of Atlanta; Atlanta, GA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Dec 06. Date of Electronic Publication: 2024 Dec 06.