In vivo efficacy of a synthetic coumarin derivative in a murine model of aspergillosis.

Autor: Seema Singh, Rajesh Dabur, Madhumanjiri M Gatne, Bharat Singh, Shilpi Gupta, Sharad Pawar, Sunil K Sharma, Gainda L Sharma

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e103039 (2014)

Despite advances in therapeutic modalities, aspergillosis remains a leading cause of mortality. This has necessitated the identification of effective and safe antifungal molecules. In the present study, in vivo safety and antifungal efficacy of a cou

Externí odkaz: https://doaj.org/article/e0cbbbc4210f47c3a916421dfcefa000

Synthesis of Potential Bioactive Novel 7-[2-Hydroxy-3-(1,2,3-triazol-1-yl)propyloxy]-3-alkyl-4-methylcoumarins

Autor: Sukhdev Singh, A. S. Arya, Divya Mathur, R. K. Singh, Ashok K. Prasad, Raju Brahma, Gainda L. Sharma, Vinod Kumar, Seema Singh, Virinder S. Parmar

Publikováno v: Journal of Heterocyclic Chemistry. 52:1-14

A series of 50 novel 7-[2-hydroxy-3-(1,2,3-triazol-1-yl)propyloxy]-3-alkyl-4-methylcoumarins had been designed and synthesized in good to excellent yields via Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction “click chemistry” of 7-(3-azido-2-hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c40e83a5b4bd3c8fa5e7af48e662b6e1
https://doi.org/10.1002/jhet.1917

Novel Cytosolic Allergens of Aspergillus fumigatus Identified from Germinating Conidia

Autor: Anju Katyal, Dharam P. Bhadoria, Bharat Singh, Michael Oellerich, Abdul R. Asif, Gainda L. Sharma, Seema Singh, Utz Reichard, Ram Kumar

Publikováno v: Journal of Proteome Research. 9:5530-5541

Aspergillus fumigatus is the common cause of allergic broncho-pulmonary aspergillosis (ABPA) and most of the allergens have been described from its secreted fraction. In the present investigation, germinating conidial cytosolic proteins of A. fumigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca20a76d75d10cf084d46f12d1204aa
https://doi.org/10.1021/pr100605c

Synthesis and antimicrobial activity of 3-arylamino-1-chloropropan-2-ols

Autor: Pankaj Kumar, Virinder S. Parmar, Hirday N. Jha, Deepti Sharma, Ashok K. Prasad, Ashish Dhawan, Manish Kumar, Anil Kumar Chhillar, Carl Erik Olsen, Vibha Yadav, Gainda L. Sharma

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:2156-2161

A series of nine 3-arylamino-1-chloropropan-2-ols 2a-2i were synthesized and their anti-fungal activity against pathogenic strains of Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger and Candida albicans, and antibacterial activity agains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d338de47ba9209a92169a4994eea791b
https://doi.org/10.1016/j.bmcl.2008.01.080

Investigations toward new lead compounds from medicinally important plants

Autor: Vineet Kumar, Sarvesh Kumar, Jesper Wengel, Virinder S. Parmar, Anil Kumar Chhillar, Carl Erik Olsen, Gainda L. Sharma, Naresh Singh, Ashok K. Prasad, Rajesh Dabur, Balaram Ghosh, Pragya Arya

Publikováno v: Prasad, A K, Kumar, V, Arya, P, Kumar, S, Dabur, R, Singh, N, Chhillar, A K, Sharma, G L, Ghosh, B, Wengel, J, Olsen, C E & Parmar, V S 2005, ' Investigations toward new lead compounds from medicinally important plants ', Pure and Applied Chemistry, vol. 77, no. 1, pp. 25-40 . https://doi.org/10.1351/pac200577010025

Extensive phytochemical investigations on 30 Piper species growing in India and other medicinal plants have revealed the presence of a large number of novel compounds belonging to different classes. The antiviral activity of several lignans and neoli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0378f1b993fbb7be9f3ece823bd65452
https://doi.org/10.1351/pac200577010025