Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Gail V.W. Johnson"'
Autor:
Anissa Elahi, Jacen Emerson, Jacob Rudlong, Jeffrey W. Keillor, Garrick Salois, Adam Visca, Peter Girardi, Gail V.W. Johnson, Christoph Pröschel
Publikováno v:
Cells, Vol 10, Iss 11, p 2942 (2021)
Following CNS injury, astrocytes become “reactive” and exhibit pro-regenerative or harmful properties. However, the molecular mechanisms that cause astrocytes to adopt either phenotype are not well understood. Transglutaminase 2 (TG2) plays a key
Externí odkaz:
https://doaj.org/article/cc4664977ba6406abc8546d4e98a1f5b
Autor:
Rodrigo A. Quintanilla, Rommy von Bernhardi, Juan A. Godoy, Nibaldo C. Inestrosa, Gail V.W. Johnson
Publikováno v:
Neurobiology of Disease, Vol 71, Iss , Pp 260-269 (2014)
Tau phosphorylated at the PHF-1 epitope (S396/S404) is likely involved in the pathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms by which tau phosphorylated at these sites negatively impacts neuronal functions are still under
Externí odkaz:
https://doaj.org/article/751241b79a06491781a8c90879a8ee7d
Autor:
Gozde Colak, Gail V.W. Johnson
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 1042-1050 (2012)
Transglutaminase 2 (TG2) is a very multifunctional protein that is ubiquitously expressed in the body. It is a Ca2+-dependent transamidating enzyme, a GTPase, as well as a scaffolding protein. TG2 is the predominant form of transglutaminase expressed
Externí odkaz:
https://doaj.org/article/7fd6187394754d08bfd5872df3b4a18a
Autor:
Wanjoo Chun, Mathieu Lesort, Janusz Tucholski, Peter W. Faber, Marcy E. MacDonald, Christopher A. Ross, Gail V.W. Johnson
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 3, Pp 391-404 (2001)
The cause of Huntington's disease (HD) is a pathological expansion of the polyglutamine domain within the N-terminal region of huntingtin. Neuronal intranuclear inclusions and cytoplasmic aggregates composed of the mutant huntingtin within certain ne
Externí odkaz:
https://doaj.org/article/31ba455244b5418a870247d3fda8b00b
Publikováno v:
Frontiers in Neurology, Vol 4 (2013)
One of the defining pathological features of Alzheimer disease (AD) is the intraneuronal accumulation of tau. Tau that forms these accumulations is altered both posttranslationally and conformationally, and there is now significant evidence that solu
Externí odkaz:
https://doaj.org/article/935e37f96df44a7f97b35b66a46a4e6e
Autor:
Shon A. Koren, Nada A. Selim, Lizbeth De La Rosa, Jacob Horn, M. Arsalan Farooqi, Alicia Y. Wei, Annika Müller-Eigner, Jacen Emerson, Gail V.W. Johnson, Andrew P. Wojtovich
Hydrogen peroxide (H2O2) functions as a second messenger to signal metabolic distress through highly compartmentalized production in mitochondria. The dynamics of ROS generation and diffusion between mitochondrial compartments and into the cytosol go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e1c9db43840618457deb9d39299979f
https://doi.org/10.1101/2023.01.07.523093
https://doi.org/10.1101/2023.01.07.523093
Autor:
Gail V.W. Johnson, Jeffrey W. Keillor
Publikováno v:
Expert Opinion on Therapeutic Targets. 25:721-731
Introduction : Transglutaminase 2 (TG2) has been implicated in numerous neurological conditions, including neurodegenerative diseases, multiple sclerosis, and CNS injury. Early studies on the role of TG2 in neurodegenerative conditions focused on its
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-16 (2020)
Molecular Neurodegeneration
Molecular Neurodegeneration
BackgroundA defining pathological hallmark of the progressive neurodegenerative disorder Alzheimer’s disease (AD) is the accumulation of misfolded tau with abnormal post-translational modifications (PTMs). These include phosphorylation at Threonine
Autor:
Carol A. Deaton, Gail V.W. Johnson
Publikováno v:
J Alzheimers Dis
Mutations in the PSEN1 gene, encoding presenilin 1 (PS1), are the most common cause of familial Alzheimer’s disease (fAD). Since the first mutations in the PSEN1 gene were discovered more than 25 years ago, many postulated functions of PS1 have bee
Publikováno v:
Mol Neurobiol
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disorder. A defining hallmark of the AD brain is the presence of intraneuronal neurofibrillary tangles (NFTs) which are made of up of abnormally modified tau, with aberrant p