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pro vyhledávání: '"Gail T. Nolan"'
Autor:
James McLeod, Jialin Mao, Yvonne S. Lin, Manoli Vourvahis, Iain Martin, Robert van Horn, Gail T. Nolan
Publikováno v:
Drug metabolism reviews. 49(1)
A key goal in the clinical development of a new molecular entity is to quickly identify whether it has the potential for drug-drug interactions. In particular, confirmation of in vitro data in the early stage of clinical development would facilitate
Publikováno v:
Toxicology and applied pharmacology. 209(2)
The pregnane X receptor (PXR) mediates the induction of enzymes involved in steroid metabolism and xenobiotic detoxification. The receptor is expressed in liver and intestinal tissues and is activated by a wide range of compounds. The ability of a di