Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gail Sievert"'
Autor:
Sagar S. Matharu, Cassidy S. Nordmann, Kurtis R. Ottman, Rahul Akkem, Douglas Palumbo, Denzel R. D. Cruz, Kenneth Campbell, Gail Sievert, Jamie Sturgill, James Z. Porterfield, Smita Joshi, Hammodah R. Alfar, Chi Peng, Irina D. Pokrovskaya, Jeffrey A. Kamykowski, Jeremy P. Wood, Beth Garvy, Maria A. Aronova, Sidney W. Whiteheart, Richard D. Leapman, Brian Storrie
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
AbstractPlatelets contribute to COVID-19 clinical manifestations, of which microclotting in the pulmonary vasculature has been a prominent symptom. To investigate the potential diagnostic contributions of overall platelet morphology and their α-gran
Externí odkaz:
https://doaj.org/article/568668bf99a4473e9c0e48d15d0ffc3d
Autor:
Jeremy P. Wood, Meenakshi Banerjee, Jamie Sturgill, Beth A. Garvy, Martha M.S. Sim, Marietta Barton-Baxter, Melissa Hollifield, Xian Li, Gail Sievert, Jerold G. Woodward, Hammodah Alfar, James Zachary Porterfield, Alice Thornton, Sidney W. Whiteheart, Kenneth S. Campbell
Publikováno v:
Blood
Background:A hypercoagulable state has been consistently reported in patients with severe Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), characterized by elevated D-dimer, prolonged PT, an
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 304:H455-H464
The L-type calcium channel (LTCC) provides trigger Ca2+for sarcoplasmic reticulum Ca-release, and LTCC function is influenced by interacting proteins including the LTCC distal COOH terminus (DCT) and calmodulin. DCT is proteolytically cleaved and rea
Autor:
Gail Sievert, David L. Geenen, R. John Solaro, Marius P. Sumandea, Rashad J. Belin, Laura A. Harvey, Pieter P. de Tombe
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 462:795-809
This study was conducted to identify molecular mechanisms which explain interventricular differences in myofilament function in experimental congestive heart failure (CHF). CHF was induced in rats by chronic aortic banding or myocardial infarction fo
Autor:
Gail Sievert, Liliana Sfichi Duke, Sachio Morimoto, Marius P. Sumandea, C. William Balke, Dong Yun Zhan, Mary L. Garcia-Cazarin, C. Amelia Sumandea
Publikováno v:
Journal of Molecular and Cellular Cardiology. 48:934-942
Ca2+ desensitization of myofilaments is indicated as a primary mechanism for the pathogenesis of familial dilated cardiomyopathy (DCM) associated with the deletion of lysine 210 (ΔK210) in cardiac troponin T (cTnT). ΔK210 knock-in mice closely reca
Publikováno v:
Journal of Biological Chemistry. 277:50165-50175
The human follicle-stimulating hormone (FSH) receptor consists of two distinct domains of approximately 330 amino acids, the N-terminal extracellular exodomain and membrane-associated endodomain including three exoloops and seven transmembrane helice
Autor:
Jonathan Satin, Guo Yin, Catherine N. Kaminski, Han Zhong Feng, Janet R. Manning, János Magyar, J. P. Jin, Douglas A. Andres, John Penn, Katherine L. Thompson, Gail Sievert
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The small GTP ase Rad is a negative regulator of voltage‐dependent L‐type calcium channel current ( I C aL ); however, the effects of Rad ablation on cardiomyocyte function are unknown. The objective of this study is to test the hypoth
Autor:
Boyd E. Haley, Carol O'Toole, Ashok J. Chavan, Krishnan Rajagopalan, Heinz Kohler, Gail Sievert, Dingyuan Lou, Gabriela Pavlinkova, Sybille Müller
Publikováno v:
Journal of Immunological Methods. 201:77-88
Herein we report a new method to rapidly photoinsert biotin into a specific and highly conserved site on the Ig structure using a mild photochemical activation step. This site resides in the Fv fragment and involves invariant residues which provide b
Autor:
Janet R Manning, Guo Yin, John Penn, Catherine Kaminski, Gail Sievert, Jonathan Satin, Douglas A Andres
Publikováno v:
Circulation Research. 113
Background: Rad is a small GTPase that regulates inward calcium current in excitable cells. In human heart failure, calcium dysregulation is accompanied by lowered levels of Rad expression, and dampened responsiveness to beta-adrenergic stimulation.
Autor:
Carmen Kiper, Nic Smith, Liren Li, Douglas A. Andres, Weikang Cai, Jonathan Satin, Geng-Xian Shi, János Magyar, Gail Sievert, Shawn M. Crump, Steven A. Niederer
Publikováno v:
Channels (Austin, Tex.). 6(3)
The L-type calcium channels (LTCC) are critical for maintaining Ca(2+)-homeostasis. In heterologous expression studies, the RGK-class of Ras-related G-proteins regulates LTCC function; however, the physiological relevance of RGK-LTCC interactions is