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of 13
pro vyhledávání: '"Gail Sckisel"'
Autor:
Shanling Shen, Gail Sckisel, Anupama Sahoo, Almin Lalani, Doug Den Otter, Josh Pearson, Jason DeVoss, Jay Cheng, Stephanie C. Casey, Ryan Case, Melissa Yang, Ray Low, Mark Daris, Bin Fan, Neeraj J. Agrawal, Khaled Ali
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Inhibitors that block the programmed cell death-1 (PD-1) pathway can potentiate endogenous antitumor immunity and have markedly improved cancer survival rates across a broad range of indications. However, these treatments work for only a minority of
Externí odkaz:
https://doaj.org/article/d0c9a9e8d22f4fb78e5617c61991f49b
Autor:
Jay Cheng, Josh T. Pearson, Bin Fan, Ali Khaled M K Z, Melissa Yang, Shanling Shen, Jason DeVoss, Anupama Sahoo, Almin Lalani, Ray Lieh Yoon Low, Neeraj Jagdish Agrawal, Mark Daris, Ryan Case, Stephanie C. Casey, Doug Den Otter, Gail Sckisel
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Inhibitors that block the programmed cell death-1 (PD-1) pathway can potentiate endogenous antitumor immunity and have markedly improved cancer survival rates across a broad range of indications. However, these treatments work for only a minority of
Autor:
Gail Sckisel, Annie Mirsoian, Julia Tietze, Arta Monjazeb, Bruce Blazar, Robert Wiltrout, William Murphy
Publikováno v:
The Journal of Immunology. 194:213.5-213.5
Agonistic immunotherapeutic regimens are being increasing applied in cancer. The thymus, and therefore naïve T cell output, is highly sensitive to stress environments. We therefore investigated thymic function following stimulatory cancer regimens (
Publikováno v:
The Journal of Immunology. 194:121.23-121.23
Obesity is increasingly becoming a pandemic affecting populations of all ages. Hallmark to obesity is a self-sustaining chronic proinflammatory response characterized by increased immune infiltrates into adipose tissue. However, most studies focus on
Autor:
Gail Sckisel, Myriam Bouchlaka, Annie Mirsoian, Can Sungur, Athena Soulika, Robert Wiltrout, Bruce Blazar, William Murphy
Publikováno v:
The Journal of Immunology. 192:73.4-73.4
Cancer immunotherapy has made great strides towards becoming a viable alternative to traditional cancer treatment options. Under the premise of specificity and long lasting memory, immunotherapy is hypothesized to provide what traditional cancer ther
Publikováno v:
The Journal of Immunology. 190:114.18-114.18
The immune system constantly maintains the intricate balance necessary to eliminate pathogens while preserving tolerance to self. We have previously shown that strong immune stimulation using agonistic αCD40/IL-2 immunotherapy (IT) results in the in
Publikováno v:
The Journal of Immunology. 190:121.15-121.15
NK-CD8 T cell regulation has been demonstrated in viral infection models. It is believed that NK cells regulate CD8 T cells to prevent exacerbated activation resulting in pathological effects. Current immunotherapy regimens use immunostimulation with
Publikováno v:
The Journal of Immunology. 190:188.20-188.20
Both aging and obesity are associated with increased distribution of visceral fat and the presence of a chronic pro-inflammatory state. Recent studies have shown that strong systemic immune stimulation with combined aCD40 and IL-2 immunotherapy (IT)
Publikováno v:
The Journal of Immunology. 190:49.15-49.15
One of the hallmarks of the adaptive immune system is the development of specificity towards antigens by immune cells. Memory T cells are an important component of acquired immunity, providing the host a great deal of protection due to their rapid ac
Autor:
Gail Sckisel, Hui-Hua Hsiao, Myriam Bouchlaka, Danice Wilkins, Julia Tietze, Bruce Blazar, William Murphy
Publikováno v:
The Journal of Immunology. 186:156.9-156.9
We have recently observed that cytokine-based immunotherapy (IT) regimens induced an Ag-nonspecific expansion of the memory T cell pool which was responsible for anti-tumor efficacy. We therefore sought to determine the effects of systemic IT on subs