Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Gail S. Harrison"'
Autor:
Gail S. Harrison, E. David Crawford, Adrie van Bokhoven, Michael Glode, Michael Pollak, Yuan Li, Thomas W. Flaig, Daniel L. Gustafson, Rajesh Agarwal, Yuzhen Tao, Lih-Jen Su, Shandra Wilson, M. Scott Lucia
Publikováno v:
The Prostate. 70:848-855
BACKGROUND Silibinin is a polyphenolic flavonolignan derived from milk thistle (Silybum marianium) with anti-oxidant properties. The purpose of the current trial was to determine the tissue and blood effects of high-dose silybin-phytosome in prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f949e0ca440b86d0acdd33b266cac06
https://doi.org/10.1002/pros.21118
https://doi.org/10.1002/pros.21118
Autor:
Lih-Jen Su, Daniel L. Gustafson, A. Scott Pierson, Thomas W. Flaig, Rajesh Agarwal, Gail S. Harrison, Frances Crighton, L. Michael Glode, Joseph A. Zirrolli
Publikováno v:
Investigational New Drugs. 25:139-146
Silibinin is a polyphenolic flavonoid isolated from milk thistle with anti-neoplastic activity in several in vitro and in vivo models of cancer, including prostate cancer. Silybin-phytosome is a commercially available formulation containing silibinin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85eedbf81b8cad228ccfc8c69838f522
https://doi.org/10.1007/s10637-006-9019-2
https://doi.org/10.1007/s10637-006-9019-2
Autor:
Terry M. Nett, Lin Qi, E. David Crawford, Barbara Frederick, Gail S. Harrison, L. Michael Glode, Xiaoming Sha, Matthew C. Allen
Publikováno v:
Cancer Research. 64:2090-2095
Pokeweed antiviral protein (PAP) is a plant-derived, highly potent ribosome inactivating protein that causes inhibition of protein translation and rapid cell death. We and others have delivered this protein to various cell types, including cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02a890d4c4c03aff36e074626394081
https://doi.org/10.1158/0008-5472.can-3192-2
https://doi.org/10.1158/0008-5472.can-3192-2
Autor:
Gail S. Harrison, Jennifer Tomczak, Kristina L Terrell, Linda Cagle, Ramesh Akkina, Henry N. Claman, Nirmal K. Banda, Elizabeth J. Shpall, Julie Campain
Publikováno v:
Journal of Hematotherapy. 7:319-331
The reconstitutive potential of CD34+-derived cord blood (CB) cells, transduced with a regulated diphtheria toxin A (DT-A) chain gene, was examined in SCID-hu mice harboring a conjoint organ composed of human thymus and liver (thy/liv). The DT-A-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c418e9f4be882937551aa00cebc4af
https://doi.org/10.1089/scd.1.1998.7.319
https://doi.org/10.1089/scd.1.1998.7.319
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1356:185-197
HIV-regulated expression of the diphtheria toxin A fragment gene (HIV-DT-A) is a potential gene therapy approach to AIDS. Since cationic liposomes are safe and non-immunogenic for in vivo gene delivery, we examined whether LipofectAMINE or DMRIE reag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c17b355feeb9466bd25b2db9dc8f2d3
https://doi.org/10.1016/s0167-4889(96)00176-0
https://doi.org/10.1016/s0167-4889(96)00176-0
Publikováno v:
Journal of Virological Methods. 63:129-136
Adeno-associated virus (AAV) is useful as an integrating vector for gene transfer. AAV recombinants are generally produced by transient co-transfection methods since it has proven difficult to generate stable packaging cell lines. Acceptable titers o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0379ba5d7d4afd048b160555b2dc5fec
https://doi.org/10.1016/s0166-0934(96)02121-0
https://doi.org/10.1016/s0166-0934(96)02121-0
Publikováno v:
Toxicon. 31:85-90
This study explores human immunodeficiency virus 1 (HIV-1)-regulated diphtheria toxin A (DT-A) gene expression as a means of eradicating HIV-infected cells. Previously, we constructed luciferase and DT-A plasmids, containing cis-acting Tat and Rev re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c718d2a5d1d77ad8cca5263d0a1de788
https://doi.org/10.1016/0041-0101(93)90360-u
https://doi.org/10.1016/0041-0101(93)90360-u
Autor:
L. Michael Glode, Françoise Maxwell, Cynthia J. Long, Ian H. Maxwell, Gail S. Harrison, Craig A. Rosen
Publikováno v:
Human Gene Therapy. 2:53-60
Expression of a gene encoding the diphtheria toxin A (DT-A) fragment, controlled by tissue specific regulatory elements, has previously been used to kill selected cell populations. Here, we have examined the feasibility of controlling DT-A expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d794d50e9758646864f315bba8b70f
https://doi.org/10.1089/hum.1991.2.1-53
https://doi.org/10.1089/hum.1991.2.1-53
Autor:
Mallikarjuna Gu, Rajesh Agarwal, Chapla Agarwal, Gail S. Harrison, Alpna Tyagi, Rana P. Singh, L. Michael Glode, Komal Raina
Publikováno v:
Molecular cancer therapeutics. 6(12 Pt 1)
Effective strategies are lacking for the management of urinary bladder cancer for which smoking is a potential risk factor. Herein, we evaluated chemoprevention of urinary bladder cancer by natural chemopreventive agents, silymarin and silibinin, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5bca20d66ec6d2f167c9b411f83490
https://pubmed.ncbi.nlm.nih.gov/18089718
https://pubmed.ncbi.nlm.nih.gov/18089718
Publikováno v:
International journal of cancer. 120(9)
The purpose of these experiments was to assess the synergistic activity of silibinin with chemotherapy agents in clinical use against prostate cancer. Silybin-phytosome, a commercially available formulation containing silibinin, has recently been stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d47f4d55f40f9a7819641fbd734fea
https://pubmed.ncbi.nlm.nih.gov/17230508
https://pubmed.ncbi.nlm.nih.gov/17230508