Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gail N. Turner"'
Autor:
Austin J. Joyce, Margitta G. Wahrenburg, Paula A. Muehlbauer, Verne A. Ray, Henry E. Holden, Gail N. Turner, David E. Amacher, John H. Ellis
Publikováno v:
Mutation Research/Genetic Toxicology. 300:79-90
Azithromycin was subjected to a series of three in vitro and one in vivo genetic toxicology assays for the detection of drug-associated gene or chromosomal effects. In the Ames Salmonella typhimurium tester strains TA1535, TA1537, TA98 and TA100, the
Autor:
Gail N. Turner, David E. Amacher
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 97:49-65
As part of a continuing effort to investigate various metabolic activation procedures in the L5178Y TK +/− → TK −/− mutation assay, a series of 18 chemicals including both carcinogens and non-carcinogens selected from 7 chemical classes were
Publikováno v:
Mutation research. 90(1)
Urine from drug-treated rodents was tested directly in the L5178Y TK +/− → TK −/− gene mutation assay for the induction of trifluorothymidine-resistant (TFT R ) mutants. 18-h urine samples collected from male CD-1 mice which had been treated
Autor:
Gail N. Turner, David E. Amacher
Publikováno v:
Annals of the New York Academy of Sciences. 407
Autor:
Gail N. Turner, David E. Amacher
Publikováno v:
Mutation research. 224(4)
L5178Y/TK 3.7.2C cells are used for the assessment of chemical mutagenesis caused by presumptive TK gene mutations or multiple loci mutations affecting the TK locus that result in dose-related increases in resistance to the toxic thymidine analog, tr
Autor:
David E. Amacher, Gail N. Turner
Publikováno v:
Mutation research. 74(6)
Individual S9 microsomal fractions prepared from normal livers of 8 rodent species or strains and from 1 rat strain pretreated with Aroclor 1254, were used to metabolize the promutagens N -acetyl-2-aminofluorene, 1,2--benzanthracene, to metabolize th
Autor:
David E. Amacher, Gail N. Turner
Publikováno v:
Mutation research. 176(1)
The mutagenic potential of the cytidine analog, 5-azacytidine (Aza Cyd), was tested at the thymidine kinase (TK) gene locus of L5178Y mouse lymphoma cells. 3-h exposure to as little as 20 ng/ml Aza Cyd yielded a substantial increase in TK-deficient L
Autor:
Gail N. Turner, David E. Amacher
Publikováno v:
Mutation research. 97(2)
L5178Y/TK+/- cells were treated with either N-acetyl-2-aminofluorene (AAF), 2-aminoanthracene (2A), benzanthracene (BA), benzo[a]pyrene (BP), 3-methylcholanthrene (3MCA), or dimethylnitrosamine (DMN) in the presence of varied concentrations (2.5-10%
Publikováno v:
Radiation Research. 73:535
Hyperthermic treatment of CHO cells at 45.5?C resulted in an increase in nonhistone protein isolated with DNA. The increase, as measured by [3H]tryptophan to [C4C]thymidine ratios, was proportional to heat duration and was 1.5 times the control after