Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gail McGarvie"'
Autor:
Samar Alzeer, Gail McGarvie, Stuart M. Johnston, Andreas Panopoulos, Elizabeth M. Ellis, Robert C. Lyon
Publikováno v:
Chemico-Biological Interactions. 178:283-287
The metabolism of the endogenous metabolite gamma-hydroxybutyrate (GHB) has been studied in a human neuroblastoma cell line SH-SY5Y as a model for examining neuronal metabolism. We show that GHB can be synthesized and released from these cells, indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4afcd8bbb89b1c474a73ec7c85a9976
https://doi.org/10.1016/j.cbi.2008.10.025
https://doi.org/10.1016/j.cbi.2008.10.025
Publikováno v:
Journal of Biological Chemistry. 282:25986-25992
γ-Hydroxybutyrate (GHB) is an endogenous metabolite synthesized in the brain. There is strong evidence to suggest that GHB has an important role as a neurotransmitter or neuromodulator. The human aldo-keto reductase AKR7A2 has been proposed previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64786eecfd0588c9215b5651f771a834
https://doi.org/10.1074/jbc.m702465200
https://doi.org/10.1074/jbc.m702465200
Publikováno v:
Toxicology. 226:172-180
We have developed transgenic Chinese hamster V79 cell lines in order to examine the potential for a mouse aldo-keto reductase, AKR7A5, to protect against the toxicity of 4-hydroxynonenal (4-HNE) and related toxic aldehydes. Stable expression of mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881928976e0d92a065a581d888138bca
https://doi.org/10.1016/j.tox.2006.06.013
https://doi.org/10.1016/j.tox.2006.06.013
Autor:
Duncan M. Short, David G. Watson, Elizabeth M. Ellis, Oleg A. Barski, Gail McGarvie, Robert C. Lyon
Publikováno v:
Toxicology and Applied Pharmacology. 210:163-170
The reductive metabolism of trans, trans-muconaldehyde, a cytotoxic metabolite of benzene, was studied in mouse liver. Using an HPLC-based stopped assay, the primary reduced metabolite was identified as 6-hydroxy-trans, trans-2,4-hexadienal (OH/CHO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41918cddad6ffb1d6757480218f76e9b
https://doi.org/10.1016/j.taap.2005.09.017
https://doi.org/10.1016/j.taap.2005.09.017
Publikováno v:
Chemico-Biological Interactions. :263-269
We have determined the substrate specificity of a mouse aldo–keto reductase (AKR) AKR7A5, an enzyme that is similar to rat aflatoxin aldehyde reductase (AKR7A1) and to human brain succinic semialdehyde reductase (AKR7A2). Previously, we have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10496a66cc2c7aedbd5dad7ad3a8ebf
https://doi.org/10.1016/s0009-2797(02)00173-4
https://doi.org/10.1016/s0009-2797(02)00173-4
Publikováno v:
Neurochemistry international. 62(1)
Reactive aldehydes including methyl glyoxal, acrolein and 4-hydroxy-2-nonenal (4-HNE) have been implicated in the progression of neurodegenerative diseases. The reduction of aldehydes to alcohols by the aldo-keto reductase (AKR) family of enzymes may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ef4e6c55ba922fa3bb057016978f6b
https://pubmed.ncbi.nlm.nih.gov/23084985
https://pubmed.ncbi.nlm.nih.gov/23084985
Publikováno v:
The Journal of biological chemistry. 282(36)
gamma-Hydroxybutyrate (GHB) is an endogenous metabolite synthesized in the brain. There is strong evidence to suggest that GHB has an important role as a neurotransmitter or neuromodulator. The human aldo-keto reductase AKR7A2 has been proposed previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2754248bd6c4e8c2c7ad4ddf98170ed3
https://pubmed.ncbi.nlm.nih.gov/17591773
https://pubmed.ncbi.nlm.nih.gov/17591773
Publikováno v:
FEBS letters. 523(1-3)
We have characterised a novel aldo-keto reductase (AKR7A5) from mouse liver that is 78% identical to rat aflatoxin dialdehyde reductase AKR7A1 and 89% identical to human succinic semialdehyde (SSA) reductase AKR7A2. AKR7A5 can reduce 2-carboxybenzald
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f3a81d241449e97f533845595b4f55
https://pubmed.ncbi.nlm.nih.gov/12123834
https://pubmed.ncbi.nlm.nih.gov/12123834