Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gail Mayo"'
Autor:
Tebeb Gebretsadik, David W. Haas, Gail Mayo, Edward P. Acosta, C. Michael Stein, Daniel H. Johnson, Ayumi Shintani
Publikováno v:
British Journal of Clinical Pharmacology. 75:997-1006
Aims To determine pharmacokinetic and pharmacogenomic correlates of efavirenz central nervous system (CNS) side effects following a single dose. Methods Thirty-four healthy HIV-negative African Americans were administered a 600 mg dose of efavirenz.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5be818d9b18dd28728a949b73a1d9db
https://doi.org/10.1111/j.1365-2125.2012.04454.x
https://doi.org/10.1111/j.1365-2125.2012.04454.x
BACKGROUND: The antithrombotic efficacy of aspirin is attributed to its inhibition of the enzyme prostaglandin G/H synthase, which is necessary for the formation of thromboxane A2 in platelets. Thromboxane A2 is a potent vasoconstrictor and platelet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af470d7f32f73b3e366198a6f7cd03a
https://doi.org/10.1056/nejm199110173251605
https://doi.org/10.1056/nejm199110173251605
Autor:
Gail Mayo, Michael Floyd, Edward P. Acosta, C. Michael Stein, Grant R. Wilkinson, Tebeb Gebretsadik, Usha N. Menon, David W. Haas, Ayumi Shintani
Publikováno v:
The Journal of Infectious Diseases. 199:872-880
BACKGROUND Polymorphisms in CYP2B6 affect the steady-state plasma concentrations of nevirapine and efavirenz. In many resource-limited countries, a single dose of nevirapine has been widely prescribed to pregnant women at delivery, to reduce mother-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af23ec01092d0e6ce7f032e776c2a46a
https://doi.org/10.1086/597125
https://doi.org/10.1086/597125
Autor:
Gail Mayo, Aaron P. Milstone, David G. Bailey, Richard B. Kim, Philip E. Johnston, Ute I. Schwarz
Publikováno v:
British Journal of Clinical Pharmacology. 62:485-491
Aims A recent case report had suggested a citrus soft drink (Sun Drop®) may have caused clinically relevant elevations in ciclosporin levels through a grapefruit juice-like mechanism via inactivation of intestinal cytochrome P450 3A4 (CYP3A4). This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53eff1c5237e699956ef6f6a905f4fa
https://doi.org/10.1111/j.1365-2125.2005.02519.x
https://doi.org/10.1111/j.1365-2125.2005.02519.x
Autor:
Sosuke Kimura, Hirotoshi Echizen, Grant R. Wilkinson, Toshitaka Kashima, Kenji Otsubo, Gail Mayo, Ichiro Ieiri, Harumi Takahashi
Publikováno v:
Blood. 103:3055-3057
White and Japanese patients require different warfarin dosages to achieve therapeutic anticoagulation, but this can be only partly explained by genetic variability in the coding region of CYP2C9—a critical enzyme in the drug's metabolism. According
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58726cee174a4e4d13aed7e1455ba6d
https://doi.org/10.1182/blood-2003-07-2521
https://doi.org/10.1182/blood-2003-07-2521
Autor:
Daniel H, Johnson, Tebeb, Gebretsadik, Ayumi, Shintani, Gail, Mayo, Edward P, Acosta, C Michael, Stein, David W, Haas
Publikováno v:
British journal of clinical pharmacology. 75(4)
To determine pharmacokinetic and pharmacogenomic correlates of efavirenz central nervous system (CNS) side effects following a single dose.Thirty-four healthy HIV-negative African Americans were administered a 600 mg dose of efavirenz. Blood samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2006410869601e269459d905c1e7a739
https://pubmed.ncbi.nlm.nih.gov/22957905
https://pubmed.ncbi.nlm.nih.gov/22957905
Publikováno v:
Circulation. 88:556-561
BACKGROUND Even low doses of oral aspirin inhibit prostacyclin (prostaglandin [PG] I2) formation and cause gastrointestinal toxicity. We examined the skin as a novel route for continuous low-dose aspirin administration and selective inhibition of pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e503c7f89e8cb20de95bca18e30563
https://doi.org/10.1161/01.cir.88.2.556
https://doi.org/10.1161/01.cir.88.2.556
Autor:
Richard H. Ho, Ute I. Schwarz, Gail Mayo, Richard B. Kim, Rommel G. Tirona, C. Michael Stein, Leena Choi, David G. Bailey, Wooin Lee
Publikováno v:
Pharmacogenetics and genomics. 17(8)
Our aims were to evaluate the effects of polymorphisms in the hepatic drug uptake transporter organic anion transporting polypeptide 1B1 (OATP1B1, SLCO1B1) and efflux transporters multidrug resistance-associated protein 2 (MRP2, ABCC2), bile salt exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad206a4a81914c5e4612e0e22283cef
https://pubmed.ncbi.nlm.nih.gov/17622941
https://pubmed.ncbi.nlm.nih.gov/17622941
Publikováno v:
Clinical pharmacology and therapeutics. 76(4)
Background Previous studies have not demonstrated good correlations between various presumed phenotypic measures of in vivo cytochrome P450 (CYP) 3A activity. However, in reality, few have used appropriate and validated in vivo probes that consider t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d4057ea5a65607b80584a1a64f271a
https://pubmed.ncbi.nlm.nih.gov/15470333
https://pubmed.ncbi.nlm.nih.gov/15470333
Autor:
Gail Mayo, Grant R. Wilkinson, Kolari S. Bhat, Alfred L. George, Guillermo Gervasini, Michael D Floyd, Andrew L. Masica, Richard B. Kim
Publikováno v:
Pharmacogenetics. 13(10)
CYP3A activity in adults varies between individuals and it has been suggested that this has a genetic basis, possibly related to variant alleles in CYP3A4 and CYP3A5 genes. Accordingly, genotype-phenotype associations were investigated under constitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffd3c47dfca8e19230e377986d7cc14
https://pubmed.ncbi.nlm.nih.gov/14515056
https://pubmed.ncbi.nlm.nih.gov/14515056