Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Gail M. Seigel"'
Publikováno v:
Biomarker Insights, Vol 3, Pp 387-402 (2008)
Glaucoma is characterized by a loss of retinal ganglion cells (RGC) which is associated with a decrease of visual function. Neuroprotective agents as a new therapeutic strategy could prevent the remaining neurons from apoptotic cell death. Previous s
Externí odkaz:
https://doaj.org/article/6fc79bbf792648298855d44ba5878c02
Publikováno v:
Cell Transplantation, Vol 7 (1998)
The purpose of this study was to examine the effect of the ocular environment on the survival, tumorigenicity, and phenotypic marker expression of immortalized retinal precursor cells transplanted into immunocompetent adult and neonatal Sprague–Daw
Externí odkaz:
https://doaj.org/article/4af536e671444abb96f5207a5600b4e5
Autor:
Saurabh Luthra, Ashish Sharma, Joyce Dong, Aneesh Neekhra, Ana L Gramajo, Gail M Seigel, M Cristina Kenney, Baruch D Kuppermann
Publikováno v:
Indian Journal of Ophthalmology, Vol 61, Iss 12, Pp 705-710 (2013)
Purpose: To evaluate the effect of bevacizumab on the mitochondrial function of human retinal pigment epithelial (ARPE-19), rat neurosensory retinal (R28) and human microvascular endothelial (HMVEC) cells in culture. Materials and Methods: ARPE-19 an
Externí odkaz:
https://doaj.org/article/c00a9872f01042b09068068b2a45c034
Autor:
Gloria Gao-Li Wong, Dhaval K. Shah, Aman P. Singh, Leiming Guo, Ashwni Verma, Gail M. Seigel, Hsuan-Ping Cheng
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:184-199
The objective of this work was to develop a systems pharmacokinetics-pharmacodynamics (PK-PD) model that can characterize in vivo bystander effect of antibody-drug conjugate (ADC) in a heterogeneous tumor. To accomplish this goal, a coculture xenogra
Autor:
Gail M. Seigel, Dhaval K. Shah, Hans E. Grossniklaus, Pia R. Mendoza, Jidong Shan, Ezster Szalai, Yinghui Song
Publikováno v:
Oncoscience
Retinoblastoma (RB) is an ocular tumor of early childhood. Current treatments attempt to preserve visual function, but may spare chemoresistant tumor cells. One potential therapeutic target for RB is HER2, (ERBB2), expressed in RB in truncated form.
Publikováno v:
Neuroscience. 399:184-198
The cochlear nucleus, located in the brainstem, receives its afferent auditory input exclusively from the auditory nerve fibers of the ipsilateral cochlea. Noise-induced neurodegenerative changes occurring in the auditory nerve stimulate a cascade of
Autor:
Micheli S. Sielski, Denis A. Proshlyakov, Ana Leda F. Longhini, Mariana Dupont, Dibyendu Chakraborty, Delaney McFarland, Maria B. Grant, Tim F. Dorweiler, Julia V. Busik, Gail M. Seigel, Sergio Li Calzi, Sandra S Hammer, Todd A. Lydic, Cristiano P. Vieira, Yan Levitsky, Yvonne Adu-Agyeiwaah, Maximilian Sandler, Bright Asare-Bediako
Publikováno v:
Diabetologia
AIMS/HYPOTHESIS: Homo Sapiens evolved under conditions of intermittent food availability and prolonged fasting between meals. Periods of fasting are important for recovery from meal-induced oxidative and metabolic stress, and tissue repair. Constant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f08e15b4aa45aa1a024b6a3de88eab5
https://europepmc.org/articles/PMC8236268/
https://europepmc.org/articles/PMC8236268/
Publikováno v:
Neuroscience
Unilateral noise-induced hearing loss reduces the input to the central auditory pathway disrupting the excitatory and inhibitory inputs to the inferior colliculus (IC), an important binaural processing center. Little is known about the compensatory s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62932a416f401c24b110601690c7664
http://hdl.handle.net/11573/1410127
http://hdl.handle.net/11573/1410127
Autor:
Bright Asare-Bediako, Julia V. Busik, Ana Leda F. Longhini, Maximilian Sandler, Sandra S Hammer, Yan Levitsky, Micheli S. Sielski, Gail M. Seigel, Sergio Li Calzi, Todd A. Lydic, Cristiano P. Vieira, Delaney McFarland, Dorweiler Tf, Yvonne Adu-Agyeiwaah, Maria B. Grant, Denis A. Proshlyakov, Dibyendu Chakraborty, Mariana Dupont
SummaryIn diabetes, the retina, a tissue with unique metabolic needs, demonstrates dysregulation of the intricate balance between nutrient availability and utilization. This results in cholesterol accumulation, pro-inflammatory and pro-apoptotic chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af15a5f2cd90cf0ad6ec6a06e71edcf1
Publikováno v:
Molecular and Cellular Neuroscience. 85:202-210
Microglia are glial-immune cells that are essential for the function and survival of the central nervous system. Microglia not only protect neural tissues from immunological insults, but also play a critical role in neural development and repair. How