Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Gail M Seigel"'
Autor:
Saurabh Luthra, Ashish Sharma, Joyce Dong, Aneesh Neekhra, Ana L Gramajo, Gail M Seigel, M Cristina Kenney, Baruch D Kuppermann
Publikováno v:
Indian Journal of Ophthalmology, Vol 61, Iss 12, Pp 705-710 (2013)
Purpose: To evaluate the effect of bevacizumab on the mitochondrial function of human retinal pigment epithelial (ARPE-19), rat neurosensory retinal (R28) and human microvascular endothelial (HMVEC) cells in culture. Materials and Methods: ARPE-19 an
Externí odkaz:
https://doaj.org/article/c00a9872f01042b09068068b2a45c034
Autor:
Ashish Sharma, Jayaprakash A Patil, Ana L Gramajo, Gail M Seigel, Baruch D Kuppermann, Cristina M Kenney
Publikováno v:
Indian Journal of Ophthalmology, Vol 60, Iss 3, Pp 189-193 (2012)
Aim: To explore the molecular pathophysiology that might explain the epidemiologic association between cigarette smoke and age-related macular degeneration (AMD) by examining the effects of hydroquinone (HQ), a toxic compound present in high concentr
Externí odkaz:
https://doaj.org/article/69a04271f27440aaab5106e5ccd44b82
Autor:
Gloria Gao-Li Wong, Dhaval K. Shah, Aman P. Singh, Leiming Guo, Ashwni Verma, Gail M. Seigel, Hsuan-Ping Cheng
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:184-199
The objective of this work was to develop a systems pharmacokinetics-pharmacodynamics (PK-PD) model that can characterize in vivo bystander effect of antibody-drug conjugate (ADC) in a heterogeneous tumor. To accomplish this goal, a coculture xenogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9aa45b8b18a3e4b0b20d34ac027bde7
https://doi.org/10.1124/jpet.119.262287
https://doi.org/10.1124/jpet.119.262287
Autor:
Gail M. Seigel, Dhaval K. Shah, Hans E. Grossniklaus, Pia R. Mendoza, Jidong Shan, Ezster Szalai, Yinghui Song
Publikováno v:
Oncoscience
Retinoblastoma (RB) is an ocular tumor of early childhood. Current treatments attempt to preserve visual function, but may spare chemoresistant tumor cells. One potential therapeutic target for RB is HER2, (ERBB2), expressed in RB in truncated form.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1618d1d06f8e5cab345879e3d94110
https://doi.org/10.18632/oncoscience.489
https://doi.org/10.18632/oncoscience.489
Publikováno v:
Neuroscience. 399:184-198
The cochlear nucleus, located in the brainstem, receives its afferent auditory input exclusively from the auditory nerve fibers of the ipsilateral cochlea. Noise-induced neurodegenerative changes occurring in the auditory nerve stimulate a cascade of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c5f3bdd64444cbefb8f4239e820944
https://doi.org/10.1016/j.neuroscience.2018.12.023
https://doi.org/10.1016/j.neuroscience.2018.12.023
Autor:
Micheli S. Sielski, Denis A. Proshlyakov, Ana Leda F. Longhini, Mariana Dupont, Dibyendu Chakraborty, Delaney McFarland, Maria B. Grant, Tim F. Dorweiler, Julia V. Busik, Gail M. Seigel, Sergio Li Calzi, Sandra S Hammer, Todd A. Lydic, Cristiano P. Vieira, Yan Levitsky, Yvonne Adu-Agyeiwaah, Maximilian Sandler, Bright Asare-Bediako
Publikováno v:
Diabetologia
AIMS/HYPOTHESIS: Homo Sapiens evolved under conditions of intermittent food availability and prolonged fasting between meals. Periods of fasting are important for recovery from meal-induced oxidative and metabolic stress, and tissue repair. Constant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f08e15b4aa45aa1a024b6a3de88eab5
https://europepmc.org/articles/PMC8236268/
https://europepmc.org/articles/PMC8236268/
Publikováno v:
Neuroscience
Unilateral noise-induced hearing loss reduces the input to the central auditory pathway disrupting the excitatory and inhibitory inputs to the inferior colliculus (IC), an important binaural processing center. Little is known about the compensatory s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62932a416f401c24b110601690c7664
http://hdl.handle.net/11573/1410127
http://hdl.handle.net/11573/1410127
Publikováno v:
Molecular and Cellular Neuroscience. 85:202-210
Microglia are glial-immune cells that are essential for the function and survival of the central nervous system. Microglia not only protect neural tissues from immunological insults, but also play a critical role in neural development and repair. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ec6aee0173c0d9b2e6951b86885a91
https://doi.org/10.1016/j.mcn.2017.11.001
https://doi.org/10.1016/j.mcn.2017.11.001
Autor:
Bright Asare-Bediako, Julia V. Busik, Ana Leda F. Longhini, Maximilian Sandler, Sandra S Hammer, Yan Levitsky, Micheli S. Sielski, Gail M. Seigel, Sergio Li Calzi, Todd A. Lydic, Cristiano P. Vieira, Delaney McFarland, Dorweiler Tf, Yvonne Adu-Agyeiwaah, Maria B. Grant, Denis A. Proshlyakov, Dibyendu Chakraborty, Mariana Dupont
SummaryIn diabetes, the retina, a tissue with unique metabolic needs, demonstrates dysregulation of the intricate balance between nutrient availability and utilization. This results in cholesterol accumulation, pro-inflammatory and pro-apoptotic chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af15a5f2cd90cf0ad6ec6a06e71edcf1
Autor:
Aman P, Singh, Gail M, Seigel, Leiming, Guo, Ashwni, Verma, Gloria Gao-Li, Wong, Hsuan-Ping, Cheng, Dhaval K, Shah
Publikováno v:
J Pharmacol Exp Ther
The objective of this work was to develop a systems pharmacokinetics-pharmacodynamics (PK-PD) model that can characterize in vivo bystander effect of antibody-drug conjugate (ADC) in a heterogeneous tumor. To accomplish this goal, a coculture xenogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4b28f8ae543851ff9bf212c98ecff9e
https://pubmed.ncbi.nlm.nih.gov/32273304
https://pubmed.ncbi.nlm.nih.gov/32273304