Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Gail J. Pyne"'
Autor:
Kenea C. Udobi, Matthew R. Skelton, Keila N. Miles, Amanda N. Kokenge, Marla K. Perna, Gail J. Pyne-Geithman, Joseph F. Clark, Zaza Khuchua
Publikováno v:
Amino Acids. 48:2057-2065
Creatine (Cr) is a guanidino compound required for rapid replenishment of ATP in cells with a high-energy demand. In humans, mutations in the Cr transporter (CRT;SLC6A8) prevent Cr entry into tissue and result in a significant intellectual impairment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2149402dfac0f6fb444757b4e3a2bca
https://doi.org/10.1007/s00726-016-2291-3
https://doi.org/10.1007/s00726-016-2291-3
Autor:
Ondrej Choutka, Todd Abruzzo, Yuko Kurosawa, Danielle N. Caudell Stamper, Stacie L Demel, Daniel Woo, Sharyl Martini, Joseph F. Clark, Kunal B. Karani, Gail J. Pyne-Geithman
Publikováno v:
Current neurovascular research. 15(3)
Background In animal models, flow-loading is a necessary and sufficient hemodynamic factor to express the Cerebral Aneurysm (CA) phenotype. Using a rat model, this study characterizes the molecular events that comprise the cerebral arterial response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de28c3f29e490bf873cf915a65336889
https://pubmed.ncbi.nlm.nih.gov/29998805
https://pubmed.ncbi.nlm.nih.gov/29998805
Autor:
Stacie L Demel, Todd Abruzzo, Ondrej Choutka, Daniel Woo, Gail J. Pyne-Geithman, Joseph F. Clark
Publikováno v:
Stroke. 49
Background and purpose: In animal models, flow loading is a necessary and sufficient hemodynamic factor to express the cerebral aneurysm (CA) phenotype. Promotional biological factors may include variant forms of the adaptive response to flow loading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d39745474c7af00e8e7baf7dae294f4
https://doi.org/10.1161/str.49.suppl_1.wmp32
https://doi.org/10.1161/str.49.suppl_1.wmp32
Autor:
Yuko Kurosawa, James B. Chambers, Takiko Daikoku, Diana M. Lindquist, Stephen C. Benoit, Ton J. deGrauw, Joseph F. Clark, Victor M. Blanco, Gail J. Pyne-Geithman
Publikováno v:
Journal of Clinical Investigation. 122:2837-2846
The second-largest cause of X-linked mental retardation is a deficiency in creatine transporter (CRT; encoded by SLC6A8), which leads to speech and language disorders with severe cognitive impairment. This syndrome, caused by the absence of creatine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a01caac2db467910f4fa9483b08cef
https://doi.org/10.1172/jci59373
https://doi.org/10.1172/jci59373
Autor:
Deborah Vela, Jonathan T. Sutton, Kathryn E. Hitchcock, Kevin J. Haworth, Danielle N. Caudell Stamper, Nikolas M. Ivancevich, Gail J. Pyne-Geithman, Christy K. Holland
Publikováno v:
Ultrasound in Medicine & Biology. 37:1240-1251
Ultrasound is known to enhance recombinant tissue plasminogen activator (rt-PA) thrombolysis. In this study, occlusive porcine whole blood clots were placed in flowing plasma within living porcine carotid arteries. Ultrasonically induced stable cavit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5121ff6a958377286f97e68db97b4d9
https://doi.org/10.1016/j.ultrasmedbio.2011.05.011
https://doi.org/10.1016/j.ultrasmedbio.2011.05.011
Autor:
Paul S. Horn, Thomas W. Uhde, Dewleen G. Baker, Thomas D. Geracioti, Nosakhare N. Ekhator, Lori Shutter, Jeffrey R. Strawn, Gail J. Pyne-Geithman
Publikováno v:
Psychoneuroendocrinology. 35:1001-1007
The hypothalamic neuropeptide, orexin-A has a number of regulatory effects in humans and pre-clinical evidence suggests a link to neuroendocrine systems known to be pathophysiologically related to posttraumatic stress disorder (PTSD). However, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253169328caa5949c9a1483e41cf9e89
https://doi.org/10.1016/j.psyneuen.2010.01.001
https://doi.org/10.1016/j.psyneuen.2010.01.001
Autor:
Todd Abruzzo, Jonathan T. Sutton, Christy K. Holland, David D. McPherson, Melvin E. Klegerman, Kathryn E. Hitchcock, Deborah Vela, Gail J. Pyne-Geithman, Danielle N. Caudell, Yong-Jian Geng, Peppar E P Cyr
Publikováno v:
Journal of Controlled Release. 144:288-295
The goal of this study was to determine whether targeted, Rhodamine-labeled echogenic liposomes (Rh-ELIP) containing nanobubbles could be delivered to the arterial wall, and whether 1-MHz continuous wave ultrasound would enhance this delivery profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8760b936fa005745ecad3be6776882cc
https://doi.org/10.1016/j.jconrel.2010.02.030
https://doi.org/10.1016/j.jconrel.2010.02.030
Autor:
Roberta Franks, Anne F. Martin, Sunita Bhatti, Vlasios Manaves, Gail J. Pyne-Geithman, Mariam Farjah, Richard J. Paul, Lori A. Walker, Arthur R. Strauch
Publikováno v:
American Journal of Physiology-Cell Physiology. 293:C238-C245
Isoforms of the smooth muscle myosin motor, SM1 and SM2, differ in length at the carboxy terminal tail region. Their proportion changes with development, hormonal status and disease, but their function is unknown. We developed mice carrying the myosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a71120a46ec85f481be2a7e75308429
https://doi.org/10.1152/ajpcell.00567.2006
https://doi.org/10.1152/ajpcell.00567.2006
Publikováno v:
Journal of Neurochemistry. 102:1990-1995
Aneurysmal subarachnoid hemorrhage is a stroke subtype with high rates of mortality and morbidity. Cerebral vasospasm can lead to ischemic injury or death and is a common complication of aneurysmal subarachnoid hemorrhage, usually occurring 3-9 days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a870a54be1fcca355b7511075f4b9f4
https://doi.org/10.1111/j.1471-4159.2007.04667.x
https://doi.org/10.1111/j.1471-4159.2007.04667.x
Autor:
Richard J. Paul, Gary E. Shull, Gbolahan Okunade, Gail J. Pyne-Geithman, Yukisato Ishida, Li Liu
Publikováno v:
American Journal of Physiology-Cell Physiology. 292:C423-C431
We previously showed that plasma membrane Ca2+-ATPase (PMCA) activity accounted for 25–30% of relaxation in bladder smooth muscle ( 8 ). Among the four PMCA isoforms only PMCA1 and PMCA4 are expressed in smooth muscle. To address the role of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82e0afe033f1aa9ce588c7ab2088689
https://doi.org/10.1152/ajpcell.00313.2006
https://doi.org/10.1152/ajpcell.00313.2006