Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gail I. Marousek"'
Publikováno v:
Journal of Clinical Virology. 38:120-125
Background: We report on two allogeneic stem cell transplant recipients who developed cytomegalovirus disease associated with new viral mutations that conferred antiviral drug resistance. Methods: Blood specimens obtained during symptomatic disease w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970da3a638590dfa8468d8536e8e5c41
https://doi.org/10.1016/j.jcv.2006.11.005
https://doi.org/10.1016/j.jcv.2006.11.005
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:2710-2715
Treatment of cytomegalovirus (CMV) infections with current antiviral drugs ganciclovir (GCV), foscarnet (FOS), and cidofovir (CDV) may select for viral drug resistance mutations. CMV UL97 phosphotransferase gene mutations at codons 460, 520, and 590
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56858b8fc34ec52b0982430f79317a6e
https://doi.org/10.1128/aac.49.7.2710-2715.2005
https://doi.org/10.1128/aac.49.7.2710-2715.2005
Autor:
John G. McHutchison, Hugo R. Rosen, Atif Zaman, Andrew Conrad, Kent D. Taylor, Sunwen Chou, Jennifer J Lentz, Steven L Rose, Gail I. Marousek
Publikováno v:
The American Journal of Gastroenterology. 97:714-720
Hepatitis C virus (HCV) is the major causal agent of non-A, non-B hepatitis and the leading indication for liver transplantation worldwide. The emerging field of immunogenetics has confirmed the significant role of heritability in host immune respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f83cd1cb6d261f2eb88e3810ad1519
https://doi.org/10.1111/j.1572-0241.2002.05552.x
https://doi.org/10.1111/j.1572-0241.2002.05552.x
Autor:
Gail I. Marousek, David M. Parenti, J. G. Ross, S. M. Gordon, W L Drew, A. G. Lavoy, R C Miner, Sunwen Chou
Publikováno v:
Journal of Infectious Diseases. 178:526-530
Three human immunodeficiency virus-infected subjects with progressive cytomegalovirus (CMV) retinitis despite prolonged antiviral therapy had buffy coat CMV isolates that were resistant to both ganciclovir and foscarnet. Genetic analysis of the resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e2fa6223ad15c3d698b8b66290258d
https://doi.org/10.1086/515648
https://doi.org/10.1086/515648
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:2557-2559
The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c8aff8ea5bfcf8f7b9da7141dc58dd
https://doi.org/10.1128/aac.00207-06
https://doi.org/10.1128/aac.00207-06
Autor:
Stephen E. Follansbee, W. Lawrence Drew, Jacob Lalezari, R C Miner, Gail I. Marousek, Susan Guentzel, Sunwen Chou, Margaret E. Poscher
Publikováno v:
The Journal of Infectious Diseases. 176:786-789
In a human immunodeficiency virus-infected subject, cytomegalovirus (CMV) isolated 9 months after the patient began oral ganciclovir prophylaxis was resistant to ganciclovir and cidofovir and contained mutations in both UL97 and Pol coding regions. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbee32e0b1f8d2e2699ea49ccd954283
https://doi.org/10.1086/517302
https://doi.org/10.1086/517302
Autor:
Gail I. Marousek, Sunwen Chou
Publikováno v:
Virology. 198:370-376
Sequences of a 2.6- to 2.9-kb open reading frame in a putative immediate-early region of the human herpesvirus 6 (HHV6) genome were determined and compared in three reference and six local isolates of HHV6. The sequences segregated into two variant g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66377958f499d90bac2fbaedcd561d68
https://doi.org/10.1006/viro.1994.1044
https://doi.org/10.1006/viro.1994.1044
Autor:
Sunwen Chou, Gail I. Marousek
Publikováno v:
Virology. 191:523-528
The envelope glycoprotein B (gB) coding sequences of two strains of human herpesvirus-6 (HHV6 GS and Z29) were determined by sequencing a 2.5-kb open reading frame adjacent to the DNA polymerase sequence. The deduced primary translation product is 83
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f377247ddbdaa7061c09cbc3769a7e1
https://doi.org/10.1016/0042-6822(92)90224-d
https://doi.org/10.1016/0042-6822(92)90224-d
Publikováno v:
The Journal of infectious diseases. 196(1)
The cytomegalovirus (CMV) UL97 kinase inhibitor maribavir (MBV) is undergoing clinical antiviral trials. Two clinical CMV isolates serially passaged in cell culture under MBV showed >20-fold increases in MBV resistance after the development of the UL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07ce4cea3c43a380510e0f7dc5ddce3
https://pubmed.ncbi.nlm.nih.gov/17538888
https://pubmed.ncbi.nlm.nih.gov/17538888
Autor:
Gail I. Marousek, Sunwen Chou
Publikováno v:
Antimicrobial agents and chemotherapy. 50(10)
The cytomegalovirus (CMV) UL97 kinase inhibitor maribavir antagonized the anti-CMV effect of ganciclovir, increasing the ganciclovir 50% inhibitory concentration against a sensitive strain by up to 13-fold. Antiviral activities of foscarnet and cidof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c386eb943819af5d775c60079cd2075a
https://pubmed.ncbi.nlm.nih.gov/17005835
https://pubmed.ncbi.nlm.nih.gov/17005835