Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gail E. Grant"'
Autor:
Joshua Rokach, Rui Wang, Chintam Nagendra Reddy, Jaganmohan R. Anumolu, Shishir Chourey, Gail E. Grant, Sashikala Sivendran, Pranav Patel, Qiuji Ye, William S. Powell
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:116-125
Arachidonic acid (AA) is converted to biologically active metabolites by different pathways, one of the most important of which is initiated by 5-lipoxygenase (5-LO). 5-Hydroxyeicosatetraenoic acid (5-HETE), although possessing only weak biological a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb41df4858ac5bec0e90ac183849ef4d
https://doi.org/10.1016/j.bmc.2016.10.017
https://doi.org/10.1016/j.bmc.2016.10.017
Autor:
Bruce Mazer, J. Guay, Pranav Patel, William S. Powell, Gail E. Grant, Sylvie Gravel, Joshua Rokach
Publikováno v:
Free Radical Biology and Medicine. 50:1297-1304
B lymphocytes convert arachidonic acid (AA) to the 5-lipoxygenase products leukotriene B4 (LTB4) and 5-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) when subjected to oxidative stress. 5-HETE has little biological activity, but can be oxidized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac63a13d7b6a4fd9c14a26c9a81d4b4
https://doi.org/10.1016/j.freeradbiomed.2011.02.010
https://doi.org/10.1016/j.freeradbiomed.2011.02.010
Autor:
Jaganmohan R. Anumolu, Joshua Rokach, Karl-Rudolf Erlemann, Gail E. Grant, William S. Powell, Chantal Cossette, Pranav Patel
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:335-341
5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) is a metabolite of the 5-lipoxygenase (5-LO) product 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HETE), formed by the microsomal enzyme 5-hydroxyeicosanoid dehydrogenase (5-HEDH). 5-oxo-ETE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbad54c9bc92c91528134c0f3dc41b82
https://doi.org/10.1124/jpet.108.143453
https://doi.org/10.1124/jpet.108.143453
Publikováno v:
The Journal of Organic Chemistry. 73:7213-7218
The first total synthesis of 15(R)-Me-PGD2 3 is reported. The synthesis is based on the enantioselective and stereospecific syntheses of synthon 17 and its attachment to the five-membered ring by a olefin cross metathesis reaction. This approach perm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b30163e9109e18d6d306b50b8d6ee3b
https://doi.org/10.1021/jo801190m
https://doi.org/10.1021/jo801190m
Autor:
Joshua Rokach, William S. Powell, Stephen Rubino, Pranav Patel, Sylvie Gravel, Xiaoping Wang, Gail E. Grant
The 5-lipoxygenase (5-LO) product 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), which is a potent chemoattractant for myeloid cells, is known to promote the survival of prostate cancer cells. In the present study, we found that PC3 prostate canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab297a2d5d7b2303a48f2f25cff21f2
https://europepmc.org/articles/PMC3146358/
https://europepmc.org/articles/PMC3146358/
5-Oxo-ETE is a product of the 5-lipoxygenase pathway that is formed by the oxidation of 5-HETE by 5-hydroxyeicosanoid dehydrogenase (5-HEDH). 5-HEDH is a microsomal NADP(+)-dependent enzyme that is highly selective for 5-HETE. 5-Oxo-ETE synthesis is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a434cd9a772cbcae25df89044f81e66a
https://europepmc.org/articles/PMC2906239/
https://europepmc.org/articles/PMC2906239/
Publikováno v:
ChemInform. 40
The first total synthesis of 15(R)-Me-PGD2 3 is reported. The synthesis is based on the enantioselective and stereospecific syntheses of synthon 17 and its attachment to the five-membered ring by a olefin cross metathesis reaction. This approach perm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b49df2ef9db741b635998f48e28008f
https://doi.org/10.1002/chin.200904206
https://doi.org/10.1002/chin.200904206
Autor:
Chantal Cossette, Joshua Rokach, Gail E. Grant, Gue-Jae Lee, Pranav Patel, William S. Powell, Karl-Rudolf Erlemann
Publikováno v:
The Biochemical journal. 403(1)
The 5-lipoxygenase product 5-oxo-ETE (5-oxo-eicosatetraenoic acid) is a highly potent granulocyte chemoattractant that is synthesized from 5-HETE (5-hydroxyeicosatetraenoic acid) by 5-HEDH (5-hydroxyeicosanoid dehydrogenase). In the present study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83e6e7106989eeac14e8f244134050c
https://pubmed.ncbi.nlm.nih.gov/17166093
https://pubmed.ncbi.nlm.nih.gov/17166093
Autor:
Karl-Rudolf Erlemann, Chantal Cossette, Gail E. Grant, Gue-Jae Lee, Pranav Patel, Joshua Rokach, William S. Powell
Publikováno v:
Biochemical Journal; 2007, Vol. 403 Issue 1, p157-165, 9p