Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Gail D. Lewis Phillips"'
Autor:
Lori S. Friedman, Anwesha Dey, Donald S. Kirkpatrick, Steven T. Staben, Shiva Malek, Alan G. Olivero, Timothy P. Heffron, Laurent Salphati, Gail D. Lewis Phillips, Emile G. Plise, Jonathan Cheong, Jeffrey J. Wallin, Jane Guan, Nicholas Endres, Stephen Schmidt, Eric Stawiski, William F. Forrest, Lilian Phu, Rebecca Hong, Michelle A. Nannini, Deepak Sampath, Mark Merchant, Jason Oeh, Marc Hafner, Emily J. Hanan, Kyle A. Edgar, Kyung W. Song
RTK activity plays a key role in regulating p110a degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3f61f91c6eba4539d57e9ffe438944
https://doi.org/10.1158/2159-8290.22540279
https://doi.org/10.1158/2159-8290.22540279
Autor:
Gail D. Lewis Phillips, Jennifer A. Lacap, Lisa M. Crocker, Mark X. Sliwkowski, Daniela Bumbaca Yadav, Ben-Quan Shen, Jun Guo, Guangmin Li
Supplemental Figure 1. Upregulated BHLHE41 in KPL-4 TR and BT-474M1 TR cells does not confer resistance to T-DM1. Supplemental Figure 2. Flow cytometry analysis of HER2 and MDR1 expression in KPL-4 P and TR cells, and tumor derived KPL-4 TR cells. Su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b709490029dc3505c4b128d699e8aa2c
https://doi.org/10.1158/1535-7163.22507053
https://doi.org/10.1158/1535-7163.22507053
Autor:
Lori S. Friedman, Anwesha Dey, Donald S. Kirkpatrick, Steven T. Staben, Shiva Malek, Alan G. Olivero, Timothy P. Heffron, Laurent Salphati, Gail D. Lewis Phillips, Emile G. Plise, Jonathan Cheong, Jeffrey J. Wallin, Jane Guan, Nicholas Endres, Stephen Schmidt, Eric Stawiski, William F. Forrest, Lilian Phu, Rebecca Hong, Michelle A. Nannini, Deepak Sampath, Mark Merchant, Jason Oeh, Marc Hafner, Emily J. Hanan, Kyle A. Edgar, Kyung W. Song
Taselisib and GDC-0077 have increased potency in PIK3CA-mutant cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebbfef0a013256eace3353067080c86
https://doi.org/10.1158/2159-8290.22540294.v1
https://doi.org/10.1158/2159-8290.22540294.v1
Autor:
Gail D. Lewis Phillips, Jennifer A. Lacap, Lisa M. Crocker, Mark X. Sliwkowski, Daniela Bumbaca Yadav, Ben-Quan Shen, Jun Guo, Guangmin Li
Differentially expressed genes in T-DM1-resistant BT-474M1 cells with respect to the parental cell line (fold change > 2 fold and P < 0.05 of individual probes for a given gene in the microarray)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e247bc5c253cda1cb96b06e6f3477c1
https://doi.org/10.1158/1535-7163.22507044.v1
https://doi.org/10.1158/1535-7163.22507044.v1
Autor:
Lori S. Friedman, Anwesha Dey, Donald S. Kirkpatrick, Steven T. Staben, Shiva Malek, Alan G. Olivero, Timothy P. Heffron, Laurent Salphati, Gail D. Lewis Phillips, Emile G. Plise, Jonathan Cheong, Jeffrey J. Wallin, Jane Guan, Nicholas Endres, Stephen Schmidt, Eric Stawiski, William F. Forrest, Lilian Phu, Rebecca Hong, Michelle A. Nannini, Deepak Sampath, Mark Merchant, Jason Oeh, Marc Hafner, Emily J. Hanan, Kyle A. Edgar, Kyung W. Song
PIK3CA is one of the most frequently mutated oncogenes; the p110a protein it encodes plays a central role in tumor cell proliferation. Small-molecule inhibitors targeting the PI3K p110a catalytic subunit have entered clinical trials, with early-phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd67c192262a4b6f3e1d058d9266830
https://doi.org/10.1158/2159-8290.c.6549343
https://doi.org/10.1158/2159-8290.c.6549343
Autor:
Jay Tibbitts, Jan Pinkas, Manish Gupta, Charlene A. Audette, Bert Gunter, Holly A. Johnson, Elaine Mai, Carmela A. Provenzano, Douglas D. Leipold, Gail D. Lewis Phillips, Hans K. Erickson
PDF file - 101K, Mean (� SE) total antibody and conjugate pharmacokinetic parameter estimates following IV administration of T-DM1 or T-SPP-DM1 in female beige nude XID mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a677597dfc4fca4fd49a28b998e7b71
https://doi.org/10.1158/1535-7163.22497345.v1
https://doi.org/10.1158/1535-7163.22497345.v1
Autor:
Jay Tibbitts, Jan Pinkas, Manish Gupta, Charlene A. Audette, Bert Gunter, Holly A. Johnson, Elaine Mai, Carmela A. Provenzano, Douglas D. Leipold, Gail D. Lewis Phillips, Hans K. Erickson
PDF file - 133K, Target cell catabolism of T-DM1 and T-SPP-DM1 in the HER2-positive breast carcinoma cells SK-BR-3 and MCF7-neo/HER2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2021023015dc637a8bc01f8d8aca48
https://doi.org/10.1158/1535-7163.22497351
https://doi.org/10.1158/1535-7163.22497351
Autor:
Gail D. Lewis Phillips, Jennifer A. Lacap, Lisa M. Crocker, Mark X. Sliwkowski, Daniela Bumbaca Yadav, Ben-Quan Shen, Jun Guo, Guangmin Li
BT-474M1 TR vs. Parental cells, gene expression changes >5-fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f88b411457f15137f19dc1538fdcb3e
https://doi.org/10.1158/1535-7163.22507050
https://doi.org/10.1158/1535-7163.22507050
Autor:
Jay Tibbitts, Jan Pinkas, Manish Gupta, Charlene A. Audette, Bert Gunter, Holly A. Johnson, Elaine Mai, Carmela A. Provenzano, Douglas D. Leipold, Gail D. Lewis Phillips, Hans K. Erickson
Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate consisting of the anti-HER2 antibody trastuzumab linked via a nonreducible thioether linker to the maytansinoid antitubulin agent DM1. T-DM1 has shown favorable safety and efficacy in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d728000618cace1a972c51ebfc6d0d0
https://doi.org/10.1158/1535-7163.c.6535590
https://doi.org/10.1158/1535-7163.c.6535590
Autor:
Gail D. Lewis Phillips, Jennifer A. Lacap, Lisa M. Crocker, Mark X. Sliwkowski, Daniela Bumbaca Yadav, Ben-Quan Shen, Jun Guo, Guangmin Li
Differentially expressed genes in T-DM1-resistant KPL-4 cells with respect to the parental cell line (fold change > 2-fold and P < 0.05 of individual probes for a given gene in the microarray)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eac6b4a9d5a6bfca56a451497451bd0
https://doi.org/10.1158/1535-7163.22507041.v1
https://doi.org/10.1158/1535-7163.22507041.v1