Výsledky vyhledávání - "Gail D Sckisel"

Akademický článek

Bystander activation and anti-tumor effects of CD8+ T cells following Interleukin-2 based immunotherapy is independent of CD4+ T cell help.

Autor: Arta M Monjazeb, Julia K Tietze, Steven K Grossenbacher, Hui-Hua Hsiao, Anthony E Zamora, Annie Mirsoian, Brent Koehn, Bruce R Blazar, Jonathan M Weiss, Robert H Wiltrout, Gail D Sckisel, William J Murphy

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e102709 (2014)

We have previously demonstrated that immunotherapy combining agonistic anti-CD40 and IL-2 (IT) results in synergistic anti-tumor effects. IT induces expansion of highly cytolytic, antigen-independent "bystander-activated" (CD8(+)CD44high) T cells dis

Externí odkaz: https://doaj.org/article/8cc561b24e474b77877ada18789ecaf1

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Akademický článek

Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients

Autor: Craig P. Collins, Lam T. Khuat, Gail D. Sckisel, Logan V. Vick, Christine M. Minnar, Cordelia Dunai, Catherine T. Le, Brendan D. Curti, Marka Crittenden, Alexander Merleev, Michael Sheng, Nelson J. Chao, Emanual Maverakis, Spencer R. Rosario, Arta M. Monjazeb, Bruce R. Blazar, Dan L. Longo, Robert J. Canter, William J. Murphy

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of long-lived memory T c

Externí odkaz: https://doaj.org/article/1e288536df9248b1a327800dd3a6007e

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Akademický článek

Immunoediting and Antigen Loss: Overcoming the Achilles Heel of Immunotherapy with Antigen Non-Specific Therapies

Autor: Arta Monir Monjazeb, Anthony E Zamora, Steven K Grossenbacher, Annie eMirsoian, Gail D Sckisel, William J Murphy

Publikováno v: Frontiers in Oncology, Vol 3 (2013)

Cancer immunotherapy has emerged as a mainstream therapy option in the battle against cancer. Pre-clinical data demonstrates the ability of immunotherapy to harness the immune system to fight disseminated malignancy. Clinical translation has failed t

Externí odkaz: https://doaj.org/article/523307c3cfb04418a4e2b87bbb157eb6

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Akademický článek

Mechanical disruption of tumors by iron particles and magnetic field application results in increased anti-tumor immune responses.

Autor: Myriam N Bouchlaka, Gail D Sckisel, Danice Wilkins, Emanual Maverakis, Arta M Monjazeb, Maxwell Fung, Lisbeth Welniak, Doug Redelman, Alan Fuchs, Cahit A Evrensel, William J Murphy

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e48049 (2012)

The primary tumor represents a potential source of antigens for priming immune responses for disseminated disease. Current means of debulking tumors involves the use of cytoreductive conditioning that impairs immune cells or removal by surgery. We hy

Externí odkaz: https://doaj.org/article/21667970b16a43fa8f68ef51e3e2d4fa

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NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype

Autor: Ruben C Fragoso, Arta M. Monjazeb, Robert J. Canter, William J. Murphy, Steven K. Grossenbacher, Mingyi Chen, Rachel C. Smith, Shiro Urayama, Erik Ames, Stephanie Mac, Gail D. Sckisel, Jessica Perez-Cunningham, Takeshi Hagino, Thomas J. Sayers

Publikováno v: Journal of immunology (Baltimore, Md. : 1950), vol 195, iss 8

Increasing evidence supports the hypothesis that cancer stem cells (CSCs) are resistant to antiproliferative therapies, able to repopulate tumor bulk, and seed metastasis. NK cells are able to target stem cells as shown by their ability to reject all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029fa9c45e76f252b3b0e058d4cd5c5b
https://doi.org/10.4049/jimmunol.1500447

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Late administration of murine CTLA-4 blockade prolongs CD8-mediated anti-tumor effects following stimulatory cancer immunotherapy

Autor: Julia K. Tietze, Mingyi Chen, Bruce R. Blazar, Gail D. Sckisel, Myriam N. Bouchlaka, Annie Mirsoian, William J. Murphy

Publikováno v: Cancer immunology, immunotherapy : CII, vol 64, iss 12

We have demonstrated that immunostimulatory therapies such as interleukin-2 (IL-2) and anti-CD40 (αCD40) can be combined to deliver synergistic anti-tumor effects. While this strategy has shown success, efficacy varies depending on a number of facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1531ad195d600e75df36463bee071d2
https://doi.org/10.1007/s00262-015-1759-4

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Influenza infection results in local expansion of memory CD8+ T cells with antigen non-specific phenotype and function

Autor: Louis L. Lanier, Stephen O. Priest, Anthony E. Zamora, Julia K. Tietze, Hua Hui Hsiao, Gail D. Sckisel, Bruce R. Blazar, Nicole Baumgarth, William J. Murphy, Danice E. C. Wilkins

Publikováno v: Clinical and Experimental Immunology. 175:79-91

Summary Primary viral infections induce activation of CD8+ T cells responsible for effective resistance. We sought to characterize the nature of the CD8+ T cell expansion observed after primary viral infection with influenza. Infection of naive mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bc306f20db51b73dae57b98d50d063
https://doi.org/10.1111/cei.12186

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