Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Gail D Sckisel"'
Autor:
Craig P. Collins, Lam T. Khuat, Gail D. Sckisel, Logan V. Vick, Christine M. Minnar, Cordelia Dunai, Catherine T. Le, Brendan D. Curti, Marka Crittenden, Alexander Merleev, Michael Sheng, Nelson J. Chao, Emanual Maverakis, Spencer R. Rosario, Arta M. Monjazeb, Bruce R. Blazar, Dan L. Longo, Robert J. Canter, William J. Murphy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of long-lived memory T c
Externí odkaz:
https://doaj.org/article/1e288536df9248b1a327800dd3a6007e
Autor:
Gail D. Sckisel, Annie Mirsoian, Christine M. Minnar, Marka Crittenden, Brendan Curti, Jane Q. Chen, Bruce R. Blazar, Alexander D. Borowsky, Arta M. Monjazeb, William J. Murphy
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-11 (2017)
Abstract Background Studies assessing immune parameters typically utilize human PBMCs or murine splenocytes to generate data that is interpreted as representative of immune status. Using splenocytes, we have shown memory CD4-T cells that expand follo
Externí odkaz:
https://doaj.org/article/aa73a2ef07044da8b5b7a4a2e4a5bdc2
Autor:
William J. Murphy, Gail D. Sckisel, Robert J. Canter, Ellen E. Sparger, William T.N. Culp, Julian R. Perks, Abhinav Reddy, Stephen L. Shiao, Amir Kol, Mingyi Chen, Annie Mirsoian, Anthony E. Zamora, Christine Mall, Steven K. Grossenbacher, Michael S. Kent, Arta M. Monjazeb
Supplemental Figure 1: Schema and background data for the canine clinical trial; Supplemental Figure 2: flow cytometry based immunophenotyping of peripheral and tumor draining lymph nodes; Supplemental Figure 3: Flow cytometric assessment of Treg lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50107e36d448f667094eebc473fb59b9
https://doi.org/10.1158/1078-0432.22466829.v1
https://doi.org/10.1158/1078-0432.22466829.v1
Autor:
William J. Murphy, Gail D. Sckisel, Robert J. Canter, Ellen E. Sparger, William T.N. Culp, Julian R. Perks, Abhinav Reddy, Stephen L. Shiao, Amir Kol, Mingyi Chen, Annie Mirsoian, Anthony E. Zamora, Christine Mall, Steven K. Grossenbacher, Michael S. Kent, Arta M. Monjazeb
Table outlining patient characteristics of canine clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec0d68b539805376ec49aed5cedc9b3
https://doi.org/10.1158/1078-0432.22466823.v1
https://doi.org/10.1158/1078-0432.22466823.v1
Autor:
William J. Murphy, Gail D. Sckisel, Robert J. Canter, Ellen E. Sparger, William T.N. Culp, Julian R. Perks, Abhinav Reddy, Stephen L. Shiao, Amir Kol, Mingyi Chen, Annie Mirsoian, Anthony E. Zamora, Christine Mall, Steven K. Grossenbacher, Michael S. Kent, Arta M. Monjazeb
Materials and Methods for flow cytometry, pcr, tissue staining, and metabolomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c15d2cfa96b7845dedd9e726a9a2fb3
https://doi.org/10.1158/1078-0432.22466826
https://doi.org/10.1158/1078-0432.22466826
Autor:
Arta M Monjazeb, Julia K Tietze, Steven K Grossenbacher, Hui-Hua Hsiao, Anthony E Zamora, Annie Mirsoian, Brent Koehn, Bruce R Blazar, Jonathan M Weiss, Robert H Wiltrout, Gail D Sckisel, William J Murphy
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e102709 (2014)
We have previously demonstrated that immunotherapy combining agonistic anti-CD40 and IL-2 (IT) results in synergistic anti-tumor effects. IT induces expansion of highly cytolytic, antigen-independent "bystander-activated" (CD8(+)CD44high) T cells dis
Externí odkaz:
https://doaj.org/article/8cc561b24e474b77877ada18789ecaf1
Autor:
Arta Monir Monjazeb, Anthony E Zamora, Steven K Grossenbacher, Annie eMirsoian, Gail D Sckisel, William J Murphy
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
Cancer immunotherapy has emerged as a mainstream therapy option in the battle against cancer. Pre-clinical data demonstrates the ability of immunotherapy to harness the immune system to fight disseminated malignancy. Clinical translation has failed t
Externí odkaz:
https://doaj.org/article/523307c3cfb04418a4e2b87bbb157eb6
Autor:
Myriam N Bouchlaka, Gail D Sckisel, Danice Wilkins, Emanual Maverakis, Arta M Monjazeb, Maxwell Fung, Lisbeth Welniak, Doug Redelman, Alan Fuchs, Cahit A Evrensel, William J Murphy
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48049 (2012)
The primary tumor represents a potential source of antigens for priming immune responses for disseminated disease. Current means of debulking tumors involves the use of cytoreductive conditioning that impairs immune cells or removal by surgery. We hy
Externí odkaz:
https://doaj.org/article/21667970b16a43fa8f68ef51e3e2d4fa
Autor:
Ruben C Fragoso, Arta M. Monjazeb, Robert J. Canter, William J. Murphy, Steven K. Grossenbacher, Mingyi Chen, Rachel C. Smith, Shiro Urayama, Erik Ames, Stephanie Mac, Gail D. Sckisel, Jessica Perez-Cunningham, Takeshi Hagino, Thomas J. Sayers
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 195, iss 8
Increasing evidence supports the hypothesis that cancer stem cells (CSCs) are resistant to antiproliferative therapies, able to repopulate tumor bulk, and seed metastasis. NK cells are able to target stem cells as shown by their ability to reject all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029fa9c45e76f252b3b0e058d4cd5c5b
https://doi.org/10.4049/jimmunol.1500447
https://doi.org/10.4049/jimmunol.1500447
Autor:
Julia K. Tietze, Mingyi Chen, Bruce R. Blazar, Gail D. Sckisel, Myriam N. Bouchlaka, Annie Mirsoian, William J. Murphy
Publikováno v:
Cancer immunology, immunotherapy : CII, vol 64, iss 12
We have demonstrated that immunostimulatory therapies such as interleukin-2 (IL-2) and anti-CD40 (αCD40) can be combined to deliver synergistic anti-tumor effects. While this strategy has shown success, efficacy varies depending on a number of facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1531ad195d600e75df36463bee071d2
https://doi.org/10.1007/s00262-015-1759-4
https://doi.org/10.1007/s00262-015-1759-4