Zobrazeno 1 - 10
of 398
pro vyhledávání: '"Gail A. Bishop"'
Autor:
Emma L. Hornick, Gail A. Bishop
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) is an adapter protein with many context-specific functions. Early studies of lymphocyte TRAF3 hinted at TRAF3’s importance for T cell function, but elucidation of specific mechanisms
Externí odkaz:
https://doaj.org/article/6adbf295514d440f856c6ff13fa0b5f4
Autor:
Kai J. Rogers, Paige T. Richards, Zeb R. Zacharias, Laura L. Stunz, Rahul Vijay, Noah S. Butler, Kevin L. Legge, Gail A. Bishop, Wendy Maury
Publikováno v:
Viruses, Vol 15, Iss 6, p 1353 (2023)
Macrophages are critical in the pathogenesis of a diverse group of viral pathogens, both as targets of infection and for eliciting primary defense mechanisms. Our prior in vitro work identified that CD40 signaling in murine peritoneal macrophages pro
Externí odkaz:
https://doaj.org/article/8c6c1dee7bbf437da582233b4cccd168
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract TRAF3 is a versatile intracellular adapter protein with multiple context-specific roles. Uniquely in B cells, TRAF3 deficiency enhances survival and increases the risk of transformation, as loss of TRAF3 is observed in several types of B cel
Externí odkaz:
https://doaj.org/article/cabe35fe3e8245a3acd52f3226bbe784
Autor:
Emma L. Hornick, Laura L. Stunz, Shakoora Sabree, Xiaosheng Wu, Thomas E. Witzig, Gail A. Bishop
Publikováno v:
Cancers, Vol 14, Iss 20, p 5029 (2022)
TNF receptor-associated factor 3 (TRAF3) is an adapter protein that inhibits many signals that promote B cell survival and activation. Mice with a B cell-specific TRAF3 deficiency and humans with a rare haploinsufficiency in TRAF3 have enhanced devel
Externí odkaz:
https://doaj.org/article/aa8ac7cc5eb349cf9bc37067e45da7a5
Autor:
Melissa E. Munroe, Jourdan R. Anderson, Timothy F. Gross, Laura L. Stunz, Gail A. Bishop, Judith A. James
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Systemic lupus erythematosus (SLE) and other autoimmune diseases are propelled by immune dysregulation and pathogenic, disease-specific autoantibodies. Autoimmunity against the lupus autoantigen Sm is associated with cross-reactivity to Epstein-Barr
Externí odkaz:
https://doaj.org/article/cb3059a19d6b475fabedff1c96a36911
Autor:
Jami M. Gurley, Grzegorz B. Gmyrek, Elizabeth A. Hargis, Gail A. Bishop, Daniel J. J. Carr, Michael H. Elliott
Publikováno v:
Cells, Vol 10, Iss 8, p 2068 (2021)
Uncontrolled inflammation is associated with neurodegenerative conditions in central nervous system tissues, including the retina and brain. We previously found that the neural retina (NR) plays an important role in retinal immunity. Tumor necrosis f
Externí odkaz:
https://doaj.org/article/f16e54e8f5a548238f3c95ace6979ccb
Autor:
Alicia M. Wallis, Ellie C. Wallace, Bruce S. Hostager, Zuoan Yi, Jon C. D. Houtman, Gail A. Bishop
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The adaptor protein TNF receptor associated factor (TRAF) 3 is required for effective TCR signaling and normal T cell effector functions, and associates with the CD3/CD28 complex upon activation. To determine how TRAF3 promotes proximal TCR
Externí odkaz:
https://doaj.org/article/193ddd2d1b1a4ac4ac05b3cd822eef66
Autor:
Patrick M. Schlievert, Michael P. Cahill, Bruce S. Hostager, Amanda J. Brosnahan, Aloysius J. Klingelhutz, Francoise A. Gourronc, Gail A. Bishop, Donald Y. M. Leung
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Mucosal and skin tissues form barriers to infection by most bacterial pathogens. Staphylococcus aureus causes diseases across these barriers in part dependent on the proinflammatory properties of superantigens. We showed, through use of a CR
Externí odkaz:
https://doaj.org/article/49782844522c4c8c856aa6a48efa7298
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/648bca95adaf407ea0d1813f2a4b5fc4
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The adaptor protein TNF receptor-associated factor 3 (TRAF3) serves as a powerful negative regulator in multiple aspects of B cell biology. Early in vitro studies in transformed cell lines suggested the potential of TRAF3 to inhibit signaling by its
Externí odkaz:
https://doaj.org/article/c3b50a46ee4f43a39f51821c03fa9f64