Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gail, Walkinshaw"'
Autor:
John Hunter, Prachi Bagadia, Selene Li, Mitch Brenner, Veronica Rodriguez, Mark Sternlicht, Todd Seeley, Dave Olsen, Gail Walkinshaw
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/90540c79810a4570b41e0f36831a382e
Autor:
Anna Laitakari, Teemu Ollonen, Thomas Kietzmann, Gail Walkinshaw, Daniela Mennerich, Valerio Izzi, Kirsi-Maria Haapasaari, Johanna Myllyharju, Raisa Serpi, Elitsa Y. Dimova, Peppi Koivunen
Publikováno v:
Redox Biology, Vol 22, Iss , Pp - (2019)
Alcoholic fatty liver disease (AFLD) is a growing health problem for which no targeted therapy is available. We set out to study whether systemic inactivation of the main hypoxia-inducible factor prolyl 4-hydroxylase, HIF-P4H-2 (PHD2/EglN1), whose in
Externí odkaz:
https://doaj.org/article/6bb2762c679b4b848641c82d1549d47d
Autor:
David C. Gervasi, Christian H. Kjaergaard, Mitchell C. Brenner, Ingrid Langsetmo, Volkmar Guenzler, Pierre E. Signore, Steve J. Klaus, Guangjie Guo, Ughetta del Balzo, Todd W. Seeley, Gail Walkinshaw, F. Aisha Chow, Thomas B. Neff, Al Y. Lin, David Y. Liu, Lee A. Flippin, Qingjian Wang, Michael P. Arend
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:342-353
Anemia of chronic kidney disease (CKD) is a multifactorial disorder caused by impaired erythropoietin (EPO) production and altered iron homeostasis associated with inflammation. Hypoxia-inducible factor (HIF) is a transcription factor that stimulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60137ae1e3d7ebca43c18369938a576c
https://doi.org/10.1124/jpet.120.265181
https://doi.org/10.1124/jpet.120.265181
Autor:
Joona, Tapio, Riikka, Halmetoja, Elitsa Y, Dimova, Joni M, Mäki, Anu, Laitala, Gail, Walkinshaw, Johanna, Myllyharju, Raisa, Serpi, Peppi, Koivunen
Publikováno v:
The Journal of biological chemistry. 298(8)
Hypoxia-inducible factor (HIF) prolyl 4-hydroxylases (HIF-P4Hs 1-3) are druggable targets in renal anemia, where pan-HIF-P4H inhibitors induce an erythropoietic response. Preclinical data suggest that HIF-P4Hs could also be therapeutic targets for tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f75ed686c4179b4bfe7c2e818e2d5ff
https://pubmed.ncbi.nlm.nih.gov/35787374
https://pubmed.ncbi.nlm.nih.gov/35787374
Autor:
Andrew C. Perkins, Ingrid G. Winkler, Thomas Keech, Marion E. G. Brunck, Whitney Fleming, Gail Walkinshaw, Taichi Matsumoto, Jean-Pierre Levesque, Julie M. Davies, Kavita Bisht, Bianca Nowlan, Graham Magor, Crystal McGirr, Lee A. Flippin
Publikováno v:
Blood Advances. 3:406-418
In normoxia, hypoxia-inducible transcription factors (HIFs) are rapidly degraded within the cytoplasm as a consequence of their prolyl hydroxylation by oxygen-dependent prolyl hydroxylase domain (PHD) enzymes. We have previously shown that hematopoie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723ae274401a19004dd45bd902268a1b
https://doi.org/10.1182/bloodadvances.2018017566
https://doi.org/10.1182/bloodadvances.2018017566
Autor:
Tapio Röning, Johanna Magga, Anna Laitakari, Riikka Halmetoja, Joona Tapio, Elitsa Y. Dimova, Zoltan Szabo, Lea Rahtu-Korpela, Anna Kemppi, Gail Walkinshaw, Johanna Myllyharju, Risto Kerkelä, Peppi Koivunen, Raisa Serpi
Publikováno v:
Journal of molecular and cellular cardiology. 164
Aims: We have previously demonstrated protection against obesity, metabolic dysfunction, atherosclerosis and cardiac ischemia in a hypoxia-inducible factor (HIF) prolyl 4-hydroxylase-2 (Hif-p4h-2) deficient mouse line, attributing these protective ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d96eefdab531ac65380b10c4f426f8
https://pubmed.ncbi.nlm.nih.gov/34919895
https://pubmed.ncbi.nlm.nih.gov/34919895
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84767 (2014)
Ischemic stroke results in disruption of the blood-brain barrier (BBB), edema formation and neuronal cell loss. Some neuroprotective factors such as vascular endothelial growth factor (VEGF) favor edema formation, while others such as erythropoietin
Externí odkaz:
https://doaj.org/article/7cc0f69f68b14d3eabf5ba2354226ee5
Autor:
Gail Walkinshaw, Raisa Serpi, Peppi Koivunen, Johanna Myllyharju, Franziska Dengler, Helena Gylling, Anna Laitakari, Joona Tapio, Karl-Heinz Herzig, Elitsa Y. Dimova, Kari A. Mäkelä
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Abstract Non-alcoholic fatty liver disease (NAFLD) parallels the global obesity epidemic with unmet therapeutic needs. We investigated whether inhibition of hypoxia-inducible factor prolyl 4-hydroxylase-2 (HIF-P4H-2), a key cellular oxygen sensor who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd5bbf24b184127887581393a599910
http://hdl.handle.net/10138/315191
http://hdl.handle.net/10138/315191
Autor:
Bianca, Nowlan, Kathryn, Futrega, Marion E, Brunck, Gail, Walkinshaw, Lee E, Flippin, Michael R, Doran, Jean-Pierre, Levesque
Publikováno v:
Experimental hematology. 52
Granulocyte colony-stimulating factor (G-CSF) is used routinely in the clinical setting to mobilize hematopoietic stem progenitor cells (HSPCs) into the patient's blood for collection and subsequent transplantation. However, a significant proportion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0fdea963a68668565dcfb40d4a57534
https://pubmed.ncbi.nlm.nih.gov/28527810
https://pubmed.ncbi.nlm.nih.gov/28527810
Autor:
Raisa Serpi, Johanna Myllyharju, Peppi Koivunen, Teemu Ollonen, Daniela Mennerich, Anna Laitakari, Gail Walkinshaw, Thomas Kietzmann, Kirsi-Maria Haapasaari, Valerio Izzi, Elitsa Y. Dimova
Publikováno v:
Redox Biology, Vol 22, Iss, Pp-(2019)
Redox Biology
Redox Biology
Graphical abstract Image 1
Alcoholic fatty liver disease (AFLD) is a growing health problem for which no targeted therapy is available. We set out to study whether systemic inactivation of the main hypoxia-inducible factor prolyl 4-hydroxylase,
Alcoholic fatty liver disease (AFLD) is a growing health problem for which no targeted therapy is available. We set out to study whether systemic inactivation of the main hypoxia-inducible factor prolyl 4-hydroxylase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11a8d269eb607d8dbbe3e5f59221906
https://doi.org/10.1016/j.redox.2019.101145
https://doi.org/10.1016/j.redox.2019.101145