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Generation of β Cells from iPSC of a MODY8 Patient with a Novel Mutation in the Carboxyl Ester Lipase (CEL) Gene

Autor: Maurizio Ferrari, Giovanni Battista Pipitone, Gianvito Martino, Lorenzo Piemonti, Fabio Manenti, Gaia Poggi, Paola Carrera, Rita Nano, Silvia Pellegrini, Marta Tiffany Lombardo, Valeria Sordi, Alessandro Cospito

Publikováno v: J Clin Endocrinol Metab.

ContextMaturity-onset diabetes of the young (MODY) 8 is a rare form of monogenic diabetes characterized by a mutation in CEL (carboxyl ester lipase) gene, which leads to exocrine pancreas dysfunction, followed by β cell failure. Induced pluripotent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3305f5b5b10f20ce401b8740767c2d21
https://doi.org/10.1210/clinem/dgaa986

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Characterization of circulating miRNA signature in water buffaloes (Bubalus bubalis) during Brucella abortus infection and evaluation as potential biomarkers for non-invasive diagnosis in vaginal fluid

Autor: Carlotta Catozzi, Alessandra Martucciello, Gaia Poggi, Giorgia Borriello, Cristina Lecchi, Fabrizio Ceciliani, Esterina DeCarlo, Domenico Vecchio, Valentina Zamarian, Giorgio Galiero

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports

Brucellosis is an infectious disease caused by bacteria from the Brucella genus that can be transmitted to humans through contact with infected animals or contaminated animal products. Brucellosis also causes financial losses in animal production. Ru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152fdf869f34bb9ca28a2b68d231002c
http://link.springer.com/article/10.1038/s41598-018-38365-x

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Transcriptional dynamics of induced pluripotent stem cell differentiation into β cells reveals full endodermal commitment and homology with human islets

Autor: Marta Tiffany Lombardo, Fabio Manenti, Francesca Giannese, Gaia Poggi, Lorenzo Piemonti, Rita Nano, Silvia Pellegrini, Raniero Chimienti, G. Scotti, Alessandro Cospito, Valeria Sordi, Dejan Lazarevic

Publikováno v: Cytotherapy

Background aims Induced pluripotent stem cells (iPSCs) have the capacity to generate β cells in vitro, but the differentiation is incomplete and generates a variable percentage of off-target cells. Single-cell RNA sequencing offers the possibility o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13911e5b341f0e46d44334c5681a641d

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