Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gaia Pasqualetto"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
P2X receptors are a family of ATP-gated cation channels comprising seven subtypes in mammals, which play key roles in nerve transmission, pain sensation and inflammation. The P2X4 receptor in particular has attracted significant interest from pharmac
Externí odkaz:
https://doaj.org/article/c118f7db8dbf4d9cab908f16076114ed
Autor:
Gaia Pasqualetto, Andrew Mack, Emily Lewis, Ryan Cooper, Alistair Holland, Ufuk Borucu, Judith Mantell, Tom Davies, Miriam Weckener, Dan Clare, Tom Green, Pete Kille, Alex Muhlhozl, Mark T. Young
Publikováno v:
PLoS ONE, Vol 18, Iss 6 (2023)
Hemocyanins are multimeric oxygen transport proteins present in the blood of arthropods and molluscs, containing up to 8 oxygen-binding functional units per monomer. In molluscs, hemocyanins are assembled in decamer ‘building blocks’ formed of 5
Externí odkaz:
https://doaj.org/article/b7aac8c64276468c8980c9beeaa3cde2
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
P2X4 and P2X7 receptors are ATP-gated ion channels, which play important roles in neuropathic and inflammatory pain, and as such they are important drug targets in diseases of inflammatory origin. While several compounds targeting P2X4 and P2X7 recep
Externí odkaz:
https://doaj.org/article/fd03fbc848e84018863afd4fc340b93b
Autor:
Gaia Pasqualetto, Martin Schepelmann, Carmine Varricchio, Elisa Pileggi, Caroline Khogali, Siân R. Morgan, Ian Boostrom, Malgorzata Rozanowska, Andrea Brancale, Salvatore Ferla, Marcella Bassetto
Publikováno v:
Molecules, Vol 25, Iss 21, p 4904 (2020)
Accumulation of misfolded and mistrafficked rhodopsin on the endoplasmic reticulum of photoreceptor cells has a pivotal role in the pathogenesis of retinitis pigmentosa and a subset of Leber’s congenital amaurosis. One potential strategy to reduce
Externí odkaz:
https://doaj.org/article/1e783e04b31245e18c6cfa686b59132c
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
P2X receptors are trimeric eukaryotic ATP-gated cation channels. Extracellular ATP—their physiological ligand—is released as a neurotransmitter and in conditions of cell damage such as inflammation, and substantial evidence implicates P2X recepto
Externí odkaz:
https://doaj.org/article/dfa9629a2c4b492ebd6f631839f5fb3a
Autor:
Leanne Grimes, Paul J. Kemp, Andrea Brancale, Mark T. Young, Wynand van der Goes van Naters, Gaia Pasqualetto, Julia Griffiths
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
The P2X receptor family of ATP-gated cation channels are attractive drug targets for pain and inflammatory disease, but no subtype-selective agonists, and few partially selective agonists have been described to date. As proof-of-concept for the disco
Autor:
Francesca Picarazzi, Marika Zuanon, Gaia Pasqualetto, Silvia Cammarone, Isabella Romeo, Mark T. Young, Andrea Brancale, Marcella Bassetto, Mattia Mori
N-terminal P23H opsin mutation accounts for most of retinitis pigmentosa (RP) cases. P23H functions and folding can be rescued by small chaperone ligands, which contributes to validate mutant opsin as a suitable target for pharmacological treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30110d368d8aec94211fa107a9dd9693
https://cronfa.swan.ac.uk/Record/cronfa62042
https://cronfa.swan.ac.uk/Record/cronfa62042
Autor:
Elisa Pileggi, Carmine Varricchio, Malgorzata Barbara Rozanowska, Martin Schepelmann, Marcella Bassetto, Andrea Brancale, Gaia Pasqualetto
Publikováno v:
European Journal of Medicinal Chemistry. 226:113841
Inherited blinding diseases retinitis pigmentosa (RP) and a subset of Leber's congenital amaurosis (LCA) are caused by the misfolding and mistrafficking of rhodopsin molecules, which aggregate and accumulate in the endoplasmic reticulum (ER), leading
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Frontiers in Pharmacology
Frontiers in Pharmacology
P2X receptors are trimeric eukaryotic ATP-gated cation channels. Extracellular ATP - their physiological ligand - is released as a neurotransmitter and in conditions of cell damage such as inflammation, and substantial evidence implicates P2X recepto
Publikováno v:
Faraday Discuss.. 169:323-342
In this paper, we describe a hybrid meta-heuristics method of energy minimization and conformational sampling and its application into our haptic-driven molecular modelling simulator. The proposed method has been designed to suit real-time molecular