Výsledky vyhledávání - "Gaia Giuberti"

Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC

Autor: Filippo Ricciardiello, Alberto Abbruzzese, Gaia Giuberti, Michele Caraglia, Angela Lombardi, Antonio Giordano, Gabriella Misso, Anna Grimaldi, Pierosandro Tagliaferri

Publikováno v: Journal of Cellular Physiology. 228:130-141

"Advanced head and neck squamous cell cancer (HNSCC) is currently treated with taxane-based chemotherapy. We have previously shown that docetaxel (DTX) induces a ras-dependent survival signal that can be antagonized by farnesyl transferase inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e5001a3ef633ef22f9c7a58dbfde03
https://doi.org/10.1002/jcp.24112

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Theophylline-induced Apoptosis is Paralleled by Protein Kinase A-dependent Tissue Transglutaminase Activation in Cancer Cells

Autor: Anna Maria D'Alessandro, Alessandro Lentini, Monica Marra, Gaia Giuberti, Michele Caraglia, Stefano Pepe, Mariarosaria Boccellino, Simone Beninati, Alberto Abbruzzese

Publikováno v: Scopus-Elsevier

It has been reported that theophylline induces growth inhibition and apoptosis in tumour cells. We report that theophylline induces growth inhibition and apoptosis of several human epithelial tumour cells with an IC:50 of 2.5 mM after 48 h of exposur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a02608998bb788a9b47a08a09c46bf0
https://doi.org/10.1093/oxfordjournals.jbchem.a003197

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Chondroitin sulphate enhances the antitumor activity of gemcitabine and mitomycin-C in bladder cancer cells with different mechanisms

Autor: Silvia Zappavigna, Vincenzo Altieri, Sisto Perdonà, P. Sperlongano, Michele Caraglia, Matteo Ferro, Giuseppe Di Lorenzo, Gaia Giuberti, Stefania Porto, Carlo Buonerba, Gaetano Facchini, Alberto Abbruzzese

Publikováno v: Oncology reports. 27(2)

Non-muscle invasive bladder cancer is the most common type of bladder cancer in Western countries. The glycosaminoglycan (GAG) layer at the bladder surface non-specifically blocks the adherence of bacteria, ions and molecules to the bladder epitheliu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143f06c774446df216566e8964c41ee9
https://pubmed.ncbi.nlm.nih.gov/22052369

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gamma-Glutamyl 16-diaminopropane derivative of vasoactive intestinal peptide: a potent anti-oxidative agent for human epidermoid cancer cells

Autor: Vittorio Limongelli, Paola Stiuso, Angela Lombardi, Maria Cartenì, Alessandra Dicitore, Alberto Abbruzzese, Michele Caraglia, Gaia Giuberti

We previously demonstrated that the gamma-glutamyl 16 amine derivative of vasoactive intestinal peptide (VIP) acts as structural VIP agonist with affinity and potency higher than VIP. Herein, we have evaluated the effects of VIP and gamma-Gln16-diami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9809b9a623df5d1fe7224e97fd693dde
http://hdl.handle.net/11591/186929

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The N-terminal 1-16 peptide derived in vivo from protein seminal vesicle protein IV modulates alpha-thrombin activity: potential clinical implications

Autor: Gaia Giuberti, Michele Caraglia, Marilena Lepretti, Paola Stiuso, Gaetano Ammirato, Susan Costantini, Salvatore Metafora, Angelo Facchiano

Publikováno v: Experimentalmolecular medicine. 40(5)

We have previously shown that seminal vesicle protein IV (SV-IV) and its 1-70 N-terminal fragment have anti-inflammatory activity and modulate anti-thrombin III (AT) activity. Moreover, mass spectrometry analysis of purified SV-IV has shown that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cf03c169e7fe8015413464f581fa5d
https://pubmed.ncbi.nlm.nih.gov/18985012

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Bovine serum amine oxidase and spm potentiate docetaxel and interferon-alpha effects in inducing apoptosis on human cancer cells through the generation of oxidative stress

Autor: G. Tempera, Maurizio Bifulco, Michele Caraglia, Gaia Giuberti, Alberto Abbruzzese, Enzo Agostinelli, Silvia Zappavigna, Angela Lombardi, Monica Marra, Giovanni Vitale

It was previously demonstrated that bovine serum amine-oxidase (BSAO) and SPM (SPM) addition to cancer cells induces cell growth inhibition and over-run the multi-drug resistance (MDR) phenotype through the oxidative stress caused by polyamine metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6b11b38e621f1d1baebb5f7fe330e0
http://hdl.handle.net/11573/74801

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Experimental study on vasoactive intestinal peptide (VIP) and its diaminopropane bound (VIP-DAP) analog in solution

Autor: Michele Caraglia, Gaia Giuberti, Maria Cartenì, Paola Stiuso, Alessandra Dicitore, Pasquale Ferranti, D. Cassese, Alberto Abbruzzese, S. De Maria

Publikováno v: Amino acids. 35(2)

Bioactive peptides represent an exciting area of research in the fields of biochemistry and medicine and in particular the VIP/PACAP network appears to be of interest. Vasoactive intestinal peptide (VIP) is a pleiotropic factor that exerts a physiolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46981afa1a9f3db2c598cc2956522dc
https://pubmed.ncbi.nlm.nih.gov/17619118

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Anticancer drugs and hyperthermia enhance cytotoxicity induced by polyamine enzymatic oxidation products

Autor: Alfredo Budillon, G. Tempera, Angela Lombardi, Gaia Giuberti, Enzo Agostinelli, Manuela Marra, Alberto Abbruzzese, Giuseppina Meo, Michele Caraglia

A correlation between regulation of cell proliferation and polyamine metabolism is described. The latter can enter protein synthesis through the modification of eukaryotic initiation factor 5A (eIF5A) and the formation of the peculiar amino acid hypu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e77a9ae59a3d4d33351ca20c877b8ff
http://hdl.handle.net/11573/74794

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Effects of VIP and VIP-DAP on proliferation and lipid peroxidation metabolism in human KB cells

Autor: Alberto Abbruzzese, Gaia Giuberti, Maria Cartenì, D. Cassese, Michele Caraglia, Alessandra Dicitore, Marilena Lepretti, Paola Stiuso

In the present study, we have utilized the transglutaminase (TGase) enzyme to modify the primary structure of VIP with diamminopropane (DAP) at the level of the Gln16. We have investigated the conformational stability of VIP and VIP–DAP in solution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01402f02bfbc8826f7e8462d68f4eebb
http://hdl.handle.net/11591/176264

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Docetaxel induces p53-dependent apoptosis and synergizes with farnesyl transferase inhibitor r115777 in human epithelial cancer cells

Autor: Gaetano Facchini, Rosario Vincenz Iaffaioli, Monica Marra, Gaia Giuberti, Alberto Abbruzzese, Di Gennaro E, Alfredo Budillon, Francesco Caponigro, Michele Caraglia

Publikováno v: Scopus-Elsevier
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Docetaxel (Taxotere, DTX) is a promoter of apoptosis in cancer cells. Since cytotoxic mechanisms of DTX are not yet fully understood, we have investigated the effects of DTX on apoptosis and ras-->Erk-mediated signal transduction in human epidermoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d649155e419e35218f14ad5e99350fa
http://hdl.handle.net/11591/163910

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