Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Gaia Gestri"'
Autor:
Alexandra Lubin, Jason Otterstrom, Yvette Hoade, Ivana Bjedov, Eleanor Stead, Matthew Whelan, Gaia Gestri, Yael Paran, Elspeth Payne
Publikováno v:
Biology Open, Vol 10, Iss 9 (2021)
Zebrafish provide a unique opportunity for drug screening in living animals, with the fast-developing, transparent embryos allowing for relatively high-throughput, microscopy-based screens. However, the limited availability of rapid, flexible imaging
Externí odkaz:
https://doaj.org/article/dbe9a58d3e134c6e8b6b6f9413ca06f5
Autor:
Theo Issitt, Emy Bosseboeuf, Natasha De Winter, Neil Dufton, Gaia Gestri, Valentina Senatore, Anissa Chikh, Anna M. Randi, Claudio Raimondi
Publikováno v:
iScience, Vol 11, Iss , Pp 205-223 (2019)
Summary: The transmembrane protein neuropilin-1 (NRP1) promotes vascular endothelial growth factor (VEGF) and extracellular matrix signaling in endothelial cells (ECs). Although it is established that NRP1 is essential for angiogenesis, little is kno
Externí odkaz:
https://doaj.org/article/3d93fbcc84b445d396a8543ea382f882
Autor:
François Kroll, Gareth T Powell, Marcus Ghosh, Gaia Gestri, Paride Antinucci, Timothy J Hearn, Hande Tunbak, Sumi Lim, Harvey W Dennis, Joseph M Fernandez, David Whitmore, Elena Dreosti, Stephen W Wilson, Ellen J Hoffman, Jason Rihel
Publikováno v:
eLife, Vol 10 (2021)
Hundreds of human genes are associated with neurological diseases, but translation into tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to investigate genetic contributions to neurological diseases. However, curre
Externí odkaz:
https://doaj.org/article/25c5de04b6ba4affaa9daf01476b7bbd
Autor:
Rodrigo M Young, Thomas A Hawkins, Florencia Cavodeassi, Heather L Stickney, Quenten Schwarz, Lisa M Lawrence, Claudia Wierzbicki, Bowie YL Cheng, Jingyuan Luo, Elizabeth Mayela Ambrosio, Allison Klosner, Ian M Sealy, Jasmine Rowell, Chintan A Trivedi, Isaac H Bianco, Miguel L Allende, Elisabeth M Busch-Nentwich, Gaia Gestri, Stephen W Wilson
Publikováno v:
eLife, Vol 8 (2019)
The vertebrate eye originates from the eye field, a domain of cells specified by a small number of transcription factors. In this study, we show that Tcf7l1a is one such transcription factor that acts cell-autonomously to specify the eye field in zeb
Externí odkaz:
https://doaj.org/article/f4af83f9041b4ce4a7ad63e0592a4d05
Autor:
Katherine J Turner, Jacqueline Hoyle, Leonardo E Valdivia, Kara L Cerveny, Wendy Hart, Maryam Mangoli, Robert Geisler, Michele Rees, Corinne Houart, Richard J Poole, Stephen W Wilson, Gaia Gestri
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211073 (2019)
Through forward genetic screening for mutations affecting visual system development, we identified prominent coloboma and cell-autonomous retinal neuron differentiation, lamination and retinal axon projection defects in eisspalte (ele) mutant zebrafi
Externí odkaz:
https://doaj.org/article/c92a0a24d7ac4e7e901688861ff7db0b
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Coloboma is a defect in the morphogenesis of the eye that is a consequence of failure of choroid fissure fusion. It is among the most common congenital defects in humans and can significantly impact vision. However, very little is known about the cel
Externí odkaz:
https://doaj.org/article/acb8e71a44d94599ae0b030b13c34ee3
Autor:
Alessandro Fantin, Anastasia Lampropoulou, Gaia Gestri, Claudio Raimondi, Valentina Senatore, Ian Zachary, Christiana Ruhrberg
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1577-1590 (2015)
Sprouting blood vessels are led by filopodia-studded endothelial tip cells that respond to angiogenic signals. Mosaic lineage tracing previously revealed that NRP1 is essential for tip cell function, although its mechanistic role in tip cells remains
Externí odkaz:
https://doaj.org/article/604386472d1142a88f01d9eb9ebaded6
Autor:
Elena Chiavacci, Luca Dolfi, Lorena Verduci, Francesco Meghini, Gaia Gestri, Alberto Mercatanti Monica Evangelista, Stephen W Wilson, Federico Cremisi, Letizia Pitto
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50536 (2012)
tbx5, a member of the T-box gene family, encodes one of the key transcription factors mediating vertebrate heart development. Tbx5 function in heart development appears to be exquisitely sensitive to gene dosage, since both haploinsufficiency and gen
Externí odkaz:
https://doaj.org/article/b516f32f489743e3b6dacc0df9b66a84
Autor:
Markus Tschopp, Masanari Takamiya, Kara L Cerveny, Gaia Gestri, Oliver Biehlmaier, Stephen W Wilson, Uwe Strähle, Stephan C F Neuhauss
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15427 (2010)
Funduscopy is one of the most commonly used diagnostic tools in the ophthalmic practice, allowing for a ready assessment of pathological changes in the retinal vasculature and the outer retina. This non-invasive technique has so far been rarely used
Externí odkaz:
https://doaj.org/article/d99870a01688424ebae78031e5caa9a6
Autor:
María Hernández-Bejarano, Gaia Gestri, Clinton Monfries, Lisa Tucker, Elena I. Dragomir, Isaac H. Bianco, Paola Bovolenta, Stephen W. Wilson, Florencia Cavodeassi
Publikováno v:
Development. 149
Appropriate patterning of the retina during embryonic development is assumed to underlie the establishment of spatially localised specialisations that mediate the perception of specific visual features. For example, in zebrafish, an area involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f0cd147e6dbc4ba42c0c82de9ec94e
https://doi.org/10.1242/dev.200938
https://doi.org/10.1242/dev.200938