Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease

Autor: Robert Brendza, Xiaoying Gao, Kimberly L. Stark, Han Lin, Seung-Hye Lee, Changyun Hu, Hao Cai, Danielle DiCara, Yi-Chun Hsiao, Hai Ngu, Oded Foreman, Miriam Baca, Monika Dohse, Jean-Phillipe Fortin, Racquel Corpuz, Dhaya Seshasayee, Amy Easton, Gai Ayalon, Isidro Hötzel, Ben Chih

Publikováno v: Neurobiology of Disease, Vol 177, Iss , Pp 105969- (2023)

Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates. As DA

Externí odkaz: https://doaj.org/article/f3994bb352724f55b0845dad814ba7b9

Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS

Autor: Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton

Publikováno v: Neurobiology of Disease, Vol 124, Iss , Pp 340-352 (2019)

Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the disease, therapeutics that prev

Externí odkaz: https://doaj.org/article/cd3e464eb6fd4c10b7ea4c66731e7e28

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Autor: Brad A. Friedman, Karpagam Srinivasan, Gai Ayalon, William J. Meilandt, Han Lin, Melanie A. Huntley, Yi Cao, Seung-Hye Lee, Patrick C.G. Haddick, Hai Ngu, Zora Modrusan, Jessica L. Larson, Joshua S. Kaminker, Marcel P. van der Brug, David V. Hansen

Publikováno v: Cell Reports, Vol 22, Iss 3, Pp 832-847 (2018)

Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum of their possible activation states is not well understood. We derived co-regulated gene modules from transcriptional profiles of CNS myeloid cells of diverse

Externí odkaz: https://doaj.org/article/7afe276a5f3e4ad1a1ced4ec793c120a

Genome-wide association study and functional validation implicates JADE1 in tauopathy

Autor: John F. Crary, Katia de Paiva Lopes, Bradley T. Hyman, Manav Kapoor, Gloriia Novikova, Jonathan D. Glass, Valeriy Borukov, Hadley Walsh, Erin E. Franklin, Johannes Attems, Sara Shuldberg, Shea J. Andrews, Thomas J. Montine, Julie A. Schneider, Jonathan D. Cherry, C. Dirk Keene, Towfique Raj, Charles L. White, Thor D. Stein, Evan Udine, Gai Ayalon, Thao Pham, Maria M. Corrada, Weijing Tang, Ann C. McKee, Bess Frost, Marco M. Hefti, Qinwen Mao, Lei Yu, Patrick R. Hof, Peter T. Nelson, Elias M. Gonzalez, Alan E. Renton, Corey T. McMillan, Jack Humphrey, Natalia Han, Margaret E. Flanagan, SoongHo Kim, Etty Cortes, Megan A. Iida, Inma Cobos, Jeff Metcalf, Sandra Weintraub, Julie Hunkapiller, Diana K. Dangoor, Robert A. Rissman, Marcos Otero-Garcia, John Q. Trojanowski, Dushyant P. Purohit, Caitlin S. Latimer, Marla Gearing, Claudia H. Kawas, Kathryn R. Bowles, Wayne W. Poon, Brian Fulton-Howard, Edoardo Marcora, Alison Goate, Alicia Casella, Tushar Bhangale, Richard J. Perrin, Herbert T. Cohen, Bahar Salehi, Gabor G. Kovacs, Andy F. Teich, Mary Sano, Jamie M. Walker, Dennis W. Dickson, Randy Woltjer, Kristen Whitney, M.-Marsel Mesulam, Ricardo Assunção Vialle, Peter Fischer, Kurt Farrell, Jean-Paul Vonsattel, Cheick T. Sissoko, Vahram Haroutunian, Sam Gandy, Mirjam I. Lutz, Matthew P. Frosch, Nigel J. Cairns, Melissa E. Murray, Robert R. Graham, David A. Wolk, Juan C. Troncoso, Garrett Wong, Julia Kofler, Edward B. Lee, Timothy E. Richardson, Thomas G. Beach

Publikováno v: Acta Neuropathol

Primary age-related tauopathy (PART) is a neurodegenerative pathology with features distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer-type temporal lobe neurofibrillary degeneration alongside amnestic cognit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7775b39120459b31f3a484b183717e4c
https://doi.org/10.1007/s00401-021-02379-z

Activation of Muscle-Specific Kinase (MuSK) Reduces Neuromuscular Defects in the Delta7 Mouse Model of Spinal Muscular Atrophy (SMA)

Autor: Gai Ayalon, Steven J. Burden, Chien-Ping Ko, Elena-Marie Sandino Tenn, Zhihua Feng, Pei-Fen Yen, Sergey Paushkin, Arundhati Sengupta Ghosh, Karen S. Chen, Sarah Cantor, Steven Lam, Wei Zhang

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 8015, p 8015 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 15

Spinal muscular atrophy (SMA) is a motor neuron disease caused by insufficient levels of the survival motor neuron (SMN) protein. One of the most prominent pathological characteristics of SMA involves defects of the neuromuscular junction (NMJ), such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df83eb3225dda85a672b6f8cfa79d8c3
https://www.mdpi.com/1422-0067/22/15/8015