Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gahee Bahn"'
Autor:
Jinyong Lee, Hyunjun Yoon, Youn Jung Lee, Tae-Yoon Kim, Gahee Bahn, Young-heon Kim, Jun-Man Lim, Sang-Wook Park, Young-Sook Song, Mi-Sun Kim, Bo Ram Beck
Publikováno v:
Applied Sciences, Vol 13, Iss 9, p 5617 (2023)
Based on the advances made by artificial intelligence (AI) technologies in drug discovery, including target identification, hit molecule identification, and lead optimization, this study investigated natural compounds that could act as transient rece
Externí odkaz:
https://doaj.org/article/a182783767a749d4bf49a59c583d1540
Autor:
Yoon J. Lee, Jinhwan Lim, Bo Youn Choi, Jae Hoon Sul, Jin Su Park, Jihoon Han, Gahee Bahn, Jeung Whan Han, Mark P. Mattson, Ui Jeong Yun, Thiruma V. Arumugam, Sang-Ha Baik, Jong-Sung Park, Yoon Suk Cho, Soo Han Bae, Hark Kyun Kim, Seung Hyun Baek, Dong-Gyu Jo, Yuri Choi, Nobunao Wakabayashi
Publikováno v:
Proceedings of the National Academy of Sciences. 116:12516-12523
Significance Considering that Alzheimer’s disease (AD) is a chronic disease progressing over a long period of time, even a slight increase of BACE1 expression may have a profound effect on Aβ accumulation. We describe a previously unknown mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25248fd7dcb62ee97a9638f3aa9a83e
https://doi.org/10.1073/pnas.1819541116
https://doi.org/10.1073/pnas.1819541116
Autor:
Gahee Bahn, Dong-Gyu Jo
Publikováno v:
NeuroMolecular Medicine. 21:1-11
The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/NRF2) is a master transcription factor that regulates oxidative stress-related genes containing the antioxidant response element (ARE) in their promoters. The damaged function and altere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c22f7a48f3e30c8bff21d5d4c12f2d
https://doi.org/10.1007/s12017-018-08523-5
https://doi.org/10.1007/s12017-018-08523-5
Autor:
Yuri Choi, Hee Kang, Jae Hyuk Yoo, Sukchan Lee, Jeon Lee, Kye Won Park, Donghan Shin, No-Joon Song, Ki-Moon Park, Seo-Hyuk Chang, Dong Kwon Rhee, Jin-Mo Ku, Yoon Shin Cho, Suji Kim, Gahee Bahn, Jin Hee Choi, Ui Jeong Yun
Publikováno v:
Biomolecules & Therapeutics
The global obesity epidemic and associated metabolic diseases require alternative biological targets for new therapeutic strategies. In this study, we show that a phytochemical sulfuretin suppressed adipocyte differentiation of preadipocytes and admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0c72783337df4839fc66f2266aee0a
https://doi.org/10.4062/biomolther.2018.090
https://doi.org/10.4062/biomolther.2018.090
Autor:
Kye Won Park, No-Joon Song, Gahee Bahn, Suji Kim, Dong-Gyu Jo, Jin-Mo Ku, Ui Jeong Yun, Seo-Hyuk Chang
Publikováno v:
Biochemical and Biophysical Research Communications. 504:903-908
Activating transcription factor 3 (Atf3) has been previously demonstrated to impact obesity and metabolism. However, a metabolic role of Atf3 in mice remains debatable. We investigated the role of Atf3 in mice and further investigated Atf3 expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbcb7fe26bc78f82476df430d9489b3
https://doi.org/10.1016/j.bbrc.2018.09.048
https://doi.org/10.1016/j.bbrc.2018.09.048
Autor:
Yong Woo Cho, Sang Ha Baik, Dong-Gyu Jo, Dong Hoon Hyun, Jong-Sung Park, Yuri Choi, Jae Hyung Park, Jae Hoon Sul, Hark Kyun Kim, Bo Youn Choi, Gahee Bahn, Young Mo Kang, Jeung Whan Han, Yoonsuk Cho, Li Jung Kang, Siyoung Yang, Jin Su Park, Jihoon Han, Seung Hyun Baek, Thiruma V. Arumugam
Publikováno v:
Theranostics
Inhibition of Notch signalling has shown anti-inflammatory properties in vivo and in vitro models of rheumatoid arthritis (RA). The objective of this study was to determine whether Notch1 might play a role in regulating T-regulatory cells (Tregs) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbd015faf1fb4c5688f47e74cfb54e7
https://doi.org/10.7150/thno.26093
https://doi.org/10.7150/thno.26093
Autor:
Young Mo Kang, Ick Chan Kwon, Kwangmeyung Kim, Jae Hyung Park, Dong-Gyu Jo, Jong-Sung Park, Min Ju Kim, Jiyeon Jang, So Jin Lee, Seung Hyun Back, Jin Su Park, Sun Hwa Kim, Gahee Bahn
Publikováno v:
Journal of Controlled Release. 216:140-148
Notch pathway plays a pivotal role in synoviocytes involved in progression of rheumatoid arthritis (RA). Herein, we designed the Notch1 targeting siRNA delivery nanoparticles (siRNA-NPs) in order to confirm the anti-inflammatory effect in collagen-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd979344a4e31b796fb468b4a07ee901
https://doi.org/10.1016/j.jconrel.2015.08.025
https://doi.org/10.1016/j.jconrel.2015.08.025
Autor:
Christopher G. Sobey, Yi-Lin Cheng, Ye Jin Jang, Joo Yong Lee, Ui Jeong Yun, Yu I. Li, David Y. Fann, Jong-Sung Park, Hongtae Kim, Jin Su Park, Thiruma V. Arumugam, Sang Ha Baik, Bing Han Chai, Jae Hyung Park, Joon Hyung Park, Sung-Chun Tang, Takafumi Uchida, Mitchell Fane, Dong-Gyu Jo, Jae In Jeong, Yuri Choi, Seung Hyun Back, Gahee Bahn
Publikováno v:
Annals of Neurology. 77:504-516
Objective Stroke is a leading cause of mortality and disability. The peptidyl-prolyl cis/trans isomerase Pin1 regulates factors involved in cell growth. Recent evidence has shown that Pin1 plays a major role in apoptosis. However, the role of Pin1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40fdcb5274ce6b28058e2e1d583222ac
https://doi.org/10.1002/ana.24347
https://doi.org/10.1002/ana.24347
Autor:
Choon-Gon Jang, Jae-Young Koh, Jae In Jeong, Jeung Whan Han, Thiruma V. Arumugam, Dong-Gyu Jo, Yuri Choi, Doo Sin Jo, Dong-Hyung Cho, Joo Yong Lee, Jin Su Park, Jae Won Kyung, Ji Hyun Shin, Jongpil Kim, Seung Hyun Baek, So Jung Park, Gahee Bahn, Sung Hyun Kim, Bo Youn Choi, Sang-Ha Baik, Jihoon Han
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(20)
Excessive mitochondrial fission is a prominent early event and contributes to mitochondrial dysfunction, synaptic failure, and neuronal cell death in the progression of Alzheimer's disease (AD). However, it remains to be determined whether inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff34f991c6b0cc840c5d524586217038
https://pubmed.ncbi.nlm.nih.gov/28432138
https://pubmed.ncbi.nlm.nih.gov/28432138
Autor:
Bo Youn Choi, Gahee Bahn, Yoonsuk Cho, Jihoon Han, Seung Hyun Baek, HarkKyun Kim, Gun Young Jung, Dong-Gyu Jo, Hee Jin Park
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a81d3cf0d8fbef3f1585a3792cc81d6
https://doi.org/10.1016/j.jalz.2016.06.1500
https://doi.org/10.1016/j.jalz.2016.06.1500