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pro vyhledávání: '"Gagneur A"'
This work is motivated by the following problem: Can we identify the disease-causing gene in a patient affected by a monogenic disorder? This problem is an instance of root cause discovery. In particular, we aim to identify the intervened variable in
Externí odkaz:
http://arxiv.org/abs/2410.12151
Autor:
Romero, Margarida, Heiser, Laurent, Lepage, Alexandre, Gagnebien, Anne, Bonjour, Audrey, Lagarrigue, Aurélie, Palaude, Axel, Boulord, Caroline, Gagneur, Charles-Antoine, Mercier, Chloé, Caucheteux, Christelle, Guidoni-Stoltz, Dominique, Tressols, Florence, Alexandre, Frédéric, Céci, Jean-François, Metral, Jean-François, Camponovo, Jérémy, Henry, Julie, Fouché, Laurent, Hodgkins, Lianne-Blue, Comte, Marie-Hélène, Durampart, Michel, Corieri, Patricia, Olry, Paul, Reboul, Pauline, Bonfils, Philippe, Amor, Sami Ben, Collin, Simon, Ciavaldini-Cartaut, Solange, Viéville, Thierry, Batifol, Victoire, Borgne, Yann-Aël Le
Publikováno v:
Canop{\'e}. Livre blanc, 2023
As part of the Digital Working Group (GTnum) #Scol_IA "Renewal of digital practices and creative uses of digital and AI" we are pleased to present the white paper "Teaching and learning in the era of Artificial Intelligence, Acculturation, integratio
Externí odkaz:
http://arxiv.org/abs/2303.06956
Distinct genetic liability profiles define clinically relevant patient strata across common diseases
Autor:
Lucia Trastulla, Georgii Dolgalev, Sylvain Moser, Laura T. Jiménez-Barrón, Till F. M. Andlauer, Moritz von Scheidt, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Monika Budde, Urs Heilbronner, Sergi Papiol, Alexander Teumer, Georg Homuth, Henry Völzke, Marcus Dörr, Peter Falkai, Thomas G. Schulze, Julien Gagneur, Francesco Iorio, Bertram Müller-Myhsok, Heribert Schunkert, Michael J. Ziller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract Stratified medicine holds great promise to tailor treatment to the needs of individual patients. While genetics holds great potential to aid patient stratification, it remains a major challenge to operationalize complex genetic risk factor p
Externí odkaz:
https://doaj.org/article/00e3ef22c51b4762863b27a5f510cabb
Autor:
Xueqi Cao, Sandra Huber, Ata Jadid Ahari, Franziska R. Traube, Marc Seifert, Christopher C. Oakes, Polina Secheyko, Sergey Vilov, Ines F. Scheller, Nils Wagner, Vicente A. Yépez, Piers Blombery, Torsten Haferlach, Matthias Heinig, Leonhard Wachutka, Stephan Hutter, Julien Gagneur
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-21 (2024)
Abstract Background Rare oncogenic driver events, particularly affecting the expression or splicing of driver genes, are suspected to substantially contribute to the large heterogeneity of hematologic malignancies. However, their identification remai
Externí odkaz:
https://doaj.org/article/755f5087257242b19bf86f64f3d3d40e
Autor:
Wang, Y., Bernauer, J. C., Schlimme, B. S., Achenbach, P., Aulenbacher, S., Ball, M., Biroth, M., Bonaventura, D., Bosnar, D., Brand, P., Caiazza, S., Christmann, M., Cline, E., Denig, A., Distler, M. O., Doria, L., Eckert, P., Esser, A., Friscic, I., Gagneur, S., Geimer, J., Grieser, S., Gulker, P., Herrmann, P., Hoek, M., Kegel, S., Kelsey, J., Klag, P., Khoukaz, A., Kohl, M., Kolar, T., Lauß, M., Leßmann, L., Littich, M., Lunkenheimer, S., Marekovic, J., Markus, D., Mauch, M., Merkel, H., Mihovilovic, M., Milner, R. G., Muller, J., Muller, U., Petrovic, T., Pochodzalla, J., Rausch, J., Schlaadt, J., Schurg, H., Sfienti, C., Sirca, S., Spreckels, R., Stengel, S., Stottinger, Y., Szyszka, C., Thiel, M., Vestrick, S., Vidal, C.
In this paper, we describe an experiment measuring low-$Q^2$ elastic electron-proton scattering using a newly developed cryogenic supersonic gas jet target in the A1 three-spectrometer facility at the Mainz Microtron. We measured the proton electric
Externí odkaz:
http://arxiv.org/abs/2208.13689
Autor:
Alexander Karollus, Johannes Hingerl, Dennis Gankin, Martin Grosshauser, Kristian Klemon, Julien Gagneur
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background The rise of large-scale multi-species genome sequencing projects promises to shed new light on how genomes encode gene regulatory instructions. To this end, new algorithms are needed that can leverage conservation to capture regul
Externí odkaz:
https://doaj.org/article/4b05a8916fe6481881a83c500063193b
Autor:
Pedro Tomaz da Silva, Yujie Zhang, Evangelos Theodorakis, Laura D Martens, Vicente A Yépez, Vicent Pelechano, Julien Gagneur
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 5, Pp 506-520 (2024)
Abstract Codon optimality is a major determinant of mRNA translation and degradation rates. However, whether and through which mechanisms its effects are regulated remains poorly understood. Here we show that codon optimality associates with up to 2-
Externí odkaz:
https://doaj.org/article/886dcbd4f491450cb29550ad858c2b8d
Autor:
Elisabeth Esser, Eva C. Schulte, Alexander Graf, Alexander Karollus, Nicholas H. Smith, Thomas Michler, Stefan Dvoretskii, Angel Angelov, Michael Sonnabend, Silke Peter, Christina Engesser, Aleksandar Radonic, Andrea Thürmer, Max von Kleist, Friedemann Gebhardt, Clarissa Prazeres da Costa, Dirk H. Busch, Maximilian Muenchhoff, Helmut Blum, Oliver T. Keppler, Julien Gagneur, Ulrike Protzer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The SARS-CoV-2 pandemic has highlighted the need to better define in-hospital transmissions, a need that extends to all other common infectious diseases encountered in clinical settings. To evaluate how whole viral genome sequencing can cont
Externí odkaz:
https://doaj.org/article/d2e44a1b69c64e72a9c65953950f2384
Autor:
Arnaud Gagneur, Damara Gutnick, Patrick Berthiaume, Alessandro Diana, Stephen Rollnick, Prantik Saha
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
The COVID-19 pandemic highlighted Vaccine Hesitancy (VH) as an accelerating global phenomenon that must be addressed. According to the WHO, thirty to fifty percent of the world’s population are VH. Motivational Interviewing (MI) is an evidence-base
Externí odkaz:
https://doaj.org/article/df12e7b8ee34470690e64011bc790cec
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100318- (2024)
Summary: The high heritability of amyotrophic lateral sclerosis (ALS) contrasts with its low molecular diagnosis rate post-genetic testing, pointing to potential undiscovered genetic factors. To aid the exploration of these factors, we introduced Epi
Externí odkaz:
https://doaj.org/article/3a8b144d826248da985431fd70085417